A Comprehensive Guide to Rodent Models of Liver Diseases
- 1st Edition - March 15, 2025
- Imprint: Academic Press
- Authors: Savneet Kaur, Dinesh M. Tripathi
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 7 8 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 7 9 - 8
A Comprehensive Guide to Rodent Models of Liver Diseases provides the why, what, and how of preclinical models of liver disease. These models have not only substantially improved… Read more
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Request a sales quoteA Comprehensive Guide to Rodent Models of Liver Diseases provides the why, what, and how of preclinical models of liver disease. These models have not only substantially improved understanding of human liver disease pathogenesis, but also helped in developing and testing newer therapeutics as well as addressed some of the unanswered medical challenges and problems of today.
This important reference gives a detailed and in-depth review of the various animal models of human liver disorders. Well-reported animal models several human liver diseases such as fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, cholestasis, fibrosis, cirrhosis and its complications are described. Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, brief protocols, relevance, and limitations are provided.
Preclinical models used for studying liver regeneration and liver failure are also discussed. For each model, the characteristic features, updated protocols, relevance, and limitations are provided for consideration. Finally, it provides an overview of the recently developed organoid models of liver pathology.
- Presents the characteristic features of each liver disease and their respective animal models
- Delivers a summary of protocols available for making each animal model to save time in the lab
- Clarifies the precise utility of each animal model and the questions it can or cannot address
Scientists, basic biologists, PhD students and Clinician Researchers working in the field of hepatology (liver biology and hepatology research)
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- Foreword
- Preface
- Acknowledgments
- Chapter 1. An overview and pathophysiology of liver diseases
- Abstract
- All about liver in health and disease
- Liver diseases
- Viral hepatitis
- Autoimmune diseases of liver
- Alcoholic liver disease
- Portal hypertension
- Physiology of portal hypertension: hyperdynamic circulation
- Complications of cirrhosis and portal hypertension
- Cellular Components of Liver
- References
- Further Reading
- Chapter 2. Animal models for studying liver regeneration
- Abstract
- Introduction
- Liver regeneration in homeostasis
- Liver regeneration after partial hepatectomy
- Cellular and molecular mechanisms in liver regeneration after 70% partial hepatectomy
- Cellular crosstalk between parenchymal and nonparenchymal cells during liver regeneration after 70% partial hepatectomy
- Liver regeneration after acute and chronic liver injury
- Technical details of the 70% partial hepatectomy model
- Preoperative preparation and monitoring
- Anesthesia
- Surgical procedure
- Postoperative care
- Posthepatectomy procedure monitoring
- Resection of different liver lobes
- The 2-Acetylaminofluorene-partial hepatectomy model
- Conclusion
- References
- Chapter 3. Animal models of acute liver failure
- Abstract
- Introduction
- Pathophysiology of acute liver failure
- Liver toxin models of acute liver failure
- Surgical models of actue liver failure
- Conclusion
- References
- Chapter 4. Animal models of nonalcoholic fatty liver disease
- Abstract
- Introduction
- In vivo models of nonalcoholic fatty liver disease
- Animal models of nonalcoholic fatty liver disease
- Genetic models
- Chemically induced models
- Streptozotocin-induced type 2 diabetes mellitus
- Carbon tetrachloride-induced nonalcoholic steatohepatitis
- Diethylnitrosamine-induced nonalcoholic steatohepatitis
- Thioacetamide-induced nonalcoholic steatohepatitis
- Conclusion
- References
- Chapter 5. Animal models of alcoholic liver disease
- Abstract
- Introduction
- Mechanism/pathophysiology of alcoholic liver disease
- Animal models of alcoholic liver disease
- Ad libitum feeding
- Tsukamoto–French intragastric feeding
- Chronic and binge ethanol feeding (the NIAAA model)
- How to characterize alcoholic liver disease animal models?
- Conclusion
- References
- Chapter 6. Preclinical models of portal hypertension
- Abstract
- Introduction
- Pathophysiology of portal hypertension
- Animal models of cirrhotic portal hypertension
- Intoxication induced
- Surgery-based model
- Noncirrhotic animal models of portal hypertension
- Partial portal vein ligation model
- Advantages and disadvantages of cirrhotic and noncirrhotic animal models
- References
- Further Reading
- Chapter 7. Animal models for complications of cirrhosis
- Abstract
- Pulmonary vascular complications of liver disease
- Hepatopulmonary syndrome
- Pathophysiology of hepatic encephalopathy
- Key elements involved in the pathogenesis of hepatic encephalopathy includes
- Animal models of hepatic encephalopathy
- Type B hepatic encephalopathy
- Type C hepatic encephalopathy
- Surgical models
- Criteria for an effective hepatic encephalopathy model
- Animal models of acute on chronic liver failure (ACLF)
- Some of the protocols for development of acute-on-chronic liver failure model in rats are listed as follows
- Conclusion
- References
- Chapter 8. Animal models of biliary/cholestatic disease
- Abstract
- Bile acid: synthesis and transport
- Human cholestatic disorders
- Rodent models of cholestatic liver disease
- Bile duct ligation model (BDL)
- 3,5-Diethoxycarbonyl-1,4-dihydrocollidine-induced model
- Alpha-naphthylisothiocyanate (ANIT)-induced model
- Lithocholic acid (LCA)-induced model
- Ethinyl estradiol treated model
- The Mdr2 knockout mouse
- The bile salt export pump (BSEP) knockout mouse
- Conclusion
- References
- Index
- Edition: 1
- Published: March 15, 2025
- No. of pages (Paperback): 234
- No. of pages (eBook): 250
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323994781
- eBook ISBN: 9780323994798
SK
Savneet Kaur
Dr. Savneet Kaur is an Associate Professor and Scientist-in-charge of the Animal House Facility in the Department of Molecular and Cellular Medicine, Institute of liver and Biliary Sciences (ILBS), New Delhi. She has specialization in experimental hepatology and vascular biology. Her lab in ILBS is focused to investigate the role of blood and lymphatic endothelial cells in liver physiology and pathophysiology. Dr Savneet has worked on several animal models of liver regeneration and diseases. She has authored more than 70 papers in peer-reviewed reputed journals and book chapters till date.
Affiliations and expertise
Associate Professor and Scientist-in-charge of the Animal House Facility, Department of Molecular and Cellular Medicine, Institute of liver and Biliary Sciences (ILBS), New Delhi, IndiaDT
Dinesh M. Tripathi
Dr. Dinesh M Tripathi is an Associate Professor in ILBS, specializing in the areas of portal hypertension, liver physiology, pathophysiology and hepatic vascular disorders. His lab’s focus is in analyzing hepatic hemodynamics and micro-circulatory dysfunctions in small animal models of liver diseases. He has been a Postdoctoral Researcher at the Hepatic Hemodynamic Laboratory, IDIBAPS, Hospital Clinic de Barcelona, University of Barcelona, Spain, where he developed and characterized several novel pre-clinical models of advanced liver diseases and portal hypertension. He has been trained for animal experimentation in University of Barcelona, Spain.
Affiliations and expertise
Institute of Liver and Biliary, New Delhi, IndiaRead A Comprehensive Guide to Rodent Models of Liver Diseases on ScienceDirect