5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part B
- 1st Edition, Volume 261 - March 24, 2021
- Imprint: Elsevier
- Editors: Giuseppe Di Giovanni, Philippe De Deurwaerdere
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 6 4 2 5 8 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 4 - 6 4 2 5 9 - 2
The Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an internati… Read more
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Request a sales quoteThe Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
- Covers all key aspects of current research on 5-HT interaction with other neurotransmitters
- Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered
- Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists
Researchers, academics and all others interested in or involved in study of 5-HT interaction with other neurotransmitters
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Part 1: Serotonin in the CNS
- Chapter 1: Multiple facets of serotonergic modulation
- Abstract
- 1: Introduction
- 2: Cellular organization of 5-HT receptors beyond auto/hetero receptor discrimination
- 3: Regulations of the 5-HT tone by 5-HT
- 4: Conclusions
- Chapter 2: Anatomical and neurochemical organization of the serotonergic system in the mammalian brain and in particular the involvement of the dorsal raphe nucleus in relation to neurological diseases
- Abstract
- 1: Introduction
- 2: DRN morphology
- 3: Neurotransmitters of the rat DRN
- 4: Functional neuroanatomy of the DRN with emphasis on depression
- 5: Conclusion
- 6: Summary
- Chapter 3: Serotonin modulation of hippocampal functions: From anatomy to neurotherapeutics
- Abstract
- 1: Introduction
- 2: Hippocampal region
- 3: Serotonergic system in the hippocampus
- 4: The regulation of neurotransmitter tones by 5-HT in the hippocampus
- 5: Functional aspects of 5-HT controls on hippocampal function: From cell responses to behavior
- 6: Hippocampal 5-HT system dysregulation in brain diseases
- 7: Conclusion
- Acknowledgments
- Part 2: Serotonin-dopamine interactions
- Chapter 4: Serotonin/dopamine interaction: Electrophysiological and neurochemical evidence
- Abstract
- 1: Introduction
- 2: Neuroanatomical basis of the 5-HT/DA systems interaction
- 3: Global changes of 5-HT function upon DA neurotransmission
- 4: 5-HT1A receptor and the control of DA neurotransmission
- 5: 5-HT1B receptor and the control of DA neurotransmission
- 6: 5-HT2A receptor and the control of DA neurotransmission
- 7: 5-HT2B receptor and the control of DA neurotransmission
- 8: 5-HT2C receptor and the control of DA neurotransmission
- 9: Control exerted by 5-HT3 receptors in therapies
- 10: Controls exerted by 5-HT4 receptors on DA neurons
- 11: Controls exerted by 5-HT6 receptors on DA Neurons
- 12: Conclusion
- Chapter 5: Breathing new life into neurotoxic-based monkey models of Parkinson's disease to study the complex biological interplay between serotonin and dopamine
- Abstract
- 1: Parkinson's disease and serotonin
- 2: Importance of the MPTP neurotoxin in modeling Parkinson's disease in monkeys
- 3: MDMA as a tool for implementing the MPTP monkey model
- 4: Impact of MDMA administration on MPTP-intoxicated monkeys
- 5: Impact of prior MDMA administration
- 6: Concluding remarks
- Chapter 6: Serotonin/dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesia: An update
- Abstract
- Acknowledgments
- Chapter 7: Serotonergic imaging in Parkinson's disease
- Abstract
- 1: Introduction
- 2: Biology of serotonin in Parkinson's disease
- 3: In vivo molecular study of the serotonergic system in PD
- 4: Molecular imaging of the serotonergic system
- 5: Use of molecular imaging for the study of the serotonergic system in PD
- 6: Pathophysiology of serotonin modulation in Parkinson's disease
- 7: Imaging of the serotonergic system in monogenic forms of Parkinson's
- 8: Conclusions
- Part 3: Serotonin-Glutamate interaction
- Chapter 8: Cortical influences of serotonin and glutamate on layer V pyramidal neurons
- Abstract
- 1: Serotonergic modulation of the mPFC/neocortex
- 2: Thalamocortical loops as important determinants of mPFC/neocortical function
- 3: Postsynaptic effects of serotonin on mPFC/neocortical layer V pyramidal cells
- 4: Presynaptic 5-HT2A receptor activation induces glutamate release onto layer V pyramidal neuron dendrites
- 5: Presynaptic modulation of 5-HT-induced EPSPs/EPSCs by metabotropic glutamate receptors
- 6: Midline/Intralaminar thalamic nuclei is a source of afferents for 5-HT-induced EPSCs/EPSPs
- 7: 5-HT2A receptor activation and immediate early gene-like responses in mPFC/neocortex
- 8: Head twitches as a behavior manifestation of mPFC function
- 9: Motoric impulsivity and DRL 72-s behavior reflecting mPFC function
- 10: 5-HT2A-mGlu2 heterocomplex
- 11: Recent clinical Implications of 5-HT2A receptor inverse agonists and mGlu2 receptor PAMs: Major Depressive Disorder (MDD)
- 12: Recent clinical implications of serotonergic hallucinogens and MDD
- 13: Conclusions
- Chapter 9: Alterations and interactions of subcortical modulatory systems in Alzheimer's disease
- Abstract
- 1: Alzheimer's disease
- 2: Alterations in subcortical systems in Alzheimer's disease
- 3: Interactions of the serotonergic and other subcortical systems in Alzheimer's disease
- 4: Conclusions
- Chapter 10: Serotonergic control of the glutamatergic neurons of the subthalamic nucleus
- Abstract
- 1: Introduction
- 2: The STN in the basal ganglia
- 3: The 5-HT system and the STN
- 4: Electrophysiological evidence for 5-HT control of STN neuronal activity
- 5: Neurochemical and cell imaging data of the STN
- 6: 5-HT and STN functions in Parkinson's disease
- 7: 5-HT and STN function in decision making
- 8: Conclusions
- Acknowledgments
- Edition: 1
- Volume: 261
- Published: March 24, 2021
- No. of pages (Hardback): 476
- No. of pages (eBook): 476
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780444642585
- eBook ISBN: 9780444642592
GD
Giuseppe Di Giovanni
Prof. Giuseppe Di Giovanni received his Ph.D. in Neuroscience from the University of Chieti, Italy and was a postdoctoral fellow at Yale University, USA. Previously Senior Lecturer of Human Physiology at the Faculty of Medicine and Surgery, University of Palermo, and Associate Professor at the University of Malta, from 2013 he is Professor of Human Physiology at the Medical School of the University of Malta and from 2018 Honorary Professor at Cardiff University, UK. His research focuses on understanding the pathophysiology of monoaminergic systems using electrophysiological and neurochemical approach. He has published more than 120 peer-reviewed papers, edited 7 books and 6 special issues of various journals.
Affiliations and expertise
University of Malta, MaltaPD
Philippe De Deurwaerdere
Professor Philippe De Deurwaerdère, Centre National de la Recherche Scientifique Bordeaux Cedex France
Affiliations and expertise
Centre National de la Recherche Scientifique, FranceRead 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part B on ScienceDirect