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Elsevier

3D Lung Models for Regenerating Lung Tissue

  • 1st Edition - August 10, 2022
  • Latest edition
  • Editors: Gunilla Westergren-Thorsson, Sara Rolandsson Enes
  • Language: English

3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. W… Read more

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Description

3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. Written by experts in the field, readers can expect to learn more about 3D lung models, novel techniques including bioprinting and advanced imaging techniques, as well as important knowledge about the complexity of the lung and its extracellular matrix composition.

Structured into 15 different chapters, the book spans from the original 2D cell culture model on plastic, to advanced 3D lung models such as using human extracellular matrix protein. In addition, the last chapters cover new techniques including 3D printing, bioprinting, and artificial intelligence that can be used to drive the field forward and some future perspectives. This highly topical book with chapters on everything from the complexity of the lung and its microenvironment to cutting-edge 3D lung models, represents an exciting body of work that can be used by researchers during study design, grant writing, as teaching material, or to stay updated with the progression of the field.

Key features

  • A comprehensive summary of advanced 3D lung models written by the experts in the respiratory field
  • Explore novel techniques that can be used to evaluate and improve 3D lung models, including techniques such as 3D printing, bioprinting, and artificial intelligence
  • Explains what extracellular matrix is, the complexity of the lung microenvironment, and why this knowledge is important for creating a functional bioartificial lung

Readership

Senior researchers, clinicians, post-doctoral research fellows, PhD-students, medical residents, and master students with interest in the field of lung diseases and regenerative medicine

Table of contents

Introduction: Lung a complex organ to rebuild
Christopher Ward (UK, Newcastle)

Part I: Standard 2D culture on plastic

1. 2D culture on plastic, past, present, important findings and breakthroughs
GWT lab (Sweden, Lund)

2. The importance of microenvironment (ECM, GAG)
Emil Weitoft, Lund and Anders Malmström (Sweden, Lund)

Part II: 3D lung models

3. ALI model
Irene H. Heijink (The Netherlands, Groningen)

4. Biofilms
Mattias Svensson (Sweden, Stockholm)

5. Lung organoid models
Amy Ryan (Firth) (USA, Los Angeles)

6. 3D models Artificial material
Chelsea Magin (USA, Colorado)

7. 3D extracellular matrix models
Jeanette Burgess (The Netherlands, Groningen)

8. Lung-on-a-chip
Peter S. Hiemstra (The Netherlands, Leiden)

9. Flow, Mechanical properties, and bioreactors
Ramon Farre (Spain, Barcelona)

10. Challenges with 3D models and Future directions
Daniel J. Weiss (USA, Burlington)

Part III: New directions

11. 3D printing and bioprinting
Darcy E. Wagner (Sweden, Lund)

12. Drug-screening and high throughput in 3D lung models
Reinoud Gosens (The Netherlands, Groningen)

13. Model validation
Lina Gefors and Sebastian Wasserstrom (Sweden, Lund)

14. AI and computational modelling
Marko Topalovic and Wim Janssens? (Leuven, Belgium)

15. Conclusions
Sara Rolandsson Enes & Gunilla Westergren-Thorsson

Product details

  • Edition: 1
  • Latest edition
  • Published: August 10, 2022
  • Language: English

About the editors

GW

Gunilla Westergren-Thorsson

Professor in lung biology with a specific focus on extracellular matrix linked to structural changes and lung function in human chronic lung diseases. During the past decade, her research focus has shifted more towards developing human 3D lung model systems and bioreactors. She was the Dean of the Medical Department at Lund University for 6 years, and one of the chairs of the national board of SciLifeLab, working with infrastructure in Life Science at a national level to facilitate the use and edge of different techniques.
Affiliations and expertise
Professor, Lund University, Lund, Sweden

SE

Sara Rolandsson Enes

Dr. Enes is an associated researcher in lung biology with a specific focus on stem cells and their interactions with the microenvironment. During the recent years, her research focus has been on how the microenvironment affects the biology and function of stem cells and how this knowledge could be applied to improve cell therapy. In 2019, she was involved in putting together and leading a session on the topic “From 2D to 3D models of human lung disease: novel developments to rebuild the lung” for the large European Respiratory Society (ERS) annual congress. In addition, she was invited to write a landmark paper on bioartificial lungs.
Affiliations and expertise
Associated Researcher, Lund University, Lund, Sweden

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