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3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine
2nd Edition - February 18, 2022
Editors: Lijie Grace Zhang, Kam Leong, John P. Fisher
Hardback ISBN:9780128245521
9 7 8 - 0 - 1 2 - 8 2 4 5 5 2 - 1
eBook ISBN:9780128245538
9 7 8 - 0 - 1 2 - 8 2 4 5 5 3 - 8
3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their… Read more
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3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their industrial applications. Sections cover 4D Printing Smart Multi-responsive Structure, Cells for Bioprinting, 4D Printing Biomaterials, 3D/4D printing functional biomedical devices, 3D Printing for Cardiac and Heart Regeneration, Integrating 3D printing with Ultrasound for Musculoskeletal Regeneration, 3D Printing for Liver Regeneration, 3D Printing for Cancer Studies, 4D Printing Soft Bio-robots, Clinical Translation and Future Directions.
The book's team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application. The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs. This book provides an overview of these technologies and their integration.
Includes clinical applications, regulatory hurdles, and a risk-benefit analysis of each technology
Assists readers in selecting the best materials and how to identify the right parameters for printing
Includes the advantages of integrating 3D printing and nanotechnology in order to improve the safety of nano-scale materials for biomedical applications
Engineers, academics, students, clinicians and professionals in biomedical engineering, medical devices, tissue engineering, and biomaterials
Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Part I: Principles
Chapter 1. Nanotechnology: A Toolkit for Cell Behavior
Abstract
1.1 Introduction
1.2 Nanobiomaterials for Tissue Regeneration
1.3 3D Nano/Microfabrication Technology for Tissue Regeneration
1.4 Conclusion and Future Directions
Acknowledgments
Questions
References
Chapter 2. Bioprinting of Biomimetic Tissue Models for Disease Modeling and Drug Screening
Abstract
Graphical Abstract
2.1 Introduction
2.2 Current 3D Bioprinting Approaches to Build Biomimetic Tissue Models
2.3 Drug Screening and Disease Modeling Applications in Various Organs
2.4 Challenges and Future Outlook
Acknowledgments
Declaration of Interests
References
Chapter 3. 3D Bioprinting Techniques
Abstract
3.1 Introduction
3.2 Definition and Principles of 3D Bioprinting
3.3 3D Bioprinting Technologies
3.4 Challenges and Future Development of 3D Bioprinting
3.5 Conclusion
References
Chapter 4. The Power of CAD/CAM Laser Bioprinting at the Single-Cell Level: Evolution of Printing
Abstract
4.1 Introduction
4.2 Basics of Laser-Assisted Printing: Overview of Systems and Critical Ancillary Materials
4.5 Case Studies and Applications Illustrating the Importance of Single-Cell Deposition
4.6 Conclusion
References
Chapter 5. Laser Direct-Write Bioprinting: A Powerful Tool for Engineering Cellular Microenvironments
Abstract
5.1 Introduction
5.2 Materials in Laser Direct-Write
5.3 Laser Direct-Write Applications in 2D
5.4 Laser Direct-Write Applications in 3D
5.5 Conclusions and Future Directions
Acknowledgments
Questions
References
Chapter 6. Bioink Printability Methodologies for Cell-Based Extrusion Bioprinting
Abstract
6.1 Introduction
6.2 Definition of Printability
6.3 Relationships Between Printing Outcomes and Rheological Properties
6.4 Relationships Between Printing Outcomes and Process Parameters
6.5 Models for Printability
6.6 Current Limitations
6.7 Conclusion
Acknowledgments
Questions
References
Chapter 7. Hydrogels for Bioprinting
Abstract
7.1 Hydrogels in Bioprinting
7.2 Considerations for Using Hydrogel in Bioprinting
7.3 Strategies Used in Hydrogel-Based Bioprinting
7.4 Perspective and Outlook
References
Chapter 8. 4D Printing: 3D Printing of Responsive and Programmable Materials
Abstract
8.1 Introduction
8.2 Responsive and Programmable Materials for 4D Printing
8.3 Realization of 4D Printing
8.4 Applications of 4D Printing
8.5 Conclusion and Prospective
Questions
References
Part II: Applications: Nanotechnology and 3D Bioprinting for Tissue/Organ Regeneration
Chapter 9. Blood Vessel Regeneration
Abstract
9.1 Introduction
9.2 Cell-Free Scaffolds
9.3 Cell-Based Scaffolds
9.4 Comparison of the Technologies
9.5 Future Directions
Acknowledgments
References
Chapter 10. 3D Printing and Patterning Vasculature in Engineered Tissues
Abstract
10.1 Introduction
References
Chapter 11. Craniofacial and Dental Tissue
Abstract
11.1 Introduction
11.2 Clinical Need for Craniofacial and Dental Regenerative Medicine
11.3 Craniofacial and Dental Regenerative Medicine Research
11.4 Bone Tissue Engineering Strategies
11.5 Conclusions
Acknowledgment
References
Chapter 12. 3D Printing for Craniofacial Bone Regeneration
Abstract
12.1 Introduction
12.2 Anatomy and Mechanics of Craniofacial Bone
12.3 Materials for Craniofacial Scaffold
12.4 3D-Printing Techniques for Craniofacial Scaffold
12.5 Enhancing the Regenerative Capability of Biomaterials in Craniofacial Bone Regeneration
12.6 Case Studies: Application of Porous Scaffold Design for Clinical Applications
12.7 Conclusion
References
Chapter 13. Additive Manufacturing for Bone Load Bearing Applications
Abstract
13.1 Need for Bone Substitutes
13.2 Compositional, Structural and Mechanical Properties of Bone
13.3 Difficulties in Achieving an Ideal Bone Substitute
13.4 Metallic Bone Substitutes
13.5 Bioceramic Bone Substitutes
13.6 Nanocomposite Bone Substitutes
13.7 Conclusions
References
Chapter 14. 3D Printing of Cartilage and Subchondral Bone
Abstract
14.1 Background
14.2 Applications of 3D Printing
14.3 Major Challenges and Pitfalls
14.4 Future Directions
Acknowledgments
References
Chapter 15. Bioprinting for Skin
Abstract
15.1 Skin, Skin Substitutes, Possible Applications for Printed Skin
15.2 Skin Substitutes, Applications for Printed Skin
15.3 Skin Substitutes Generated by Bioprinting
15.4 Discussion of the Different Bioprinting Techniques and Clinical Applicability
15.5 Conclusion
Acknowledgments
References
Chapter 16. Nanotechnology and 3D/4D Bioprinting for Neural Tissue Regeneration
Abstract
16.1 Introduction
16.2 Nanotechnology for Neural Tissue Regeneration
16.3 3D/4D Bioprinting for Neural Tissue Regeneration
16.4 Conclusion and Future Directions
Acknowledgments
Questions
References
Chapter 17. 3D Bioprinting for Liver Regeneration
Abstract
17.1 Introduction
17.2 Structural and Functional Complexity of the Liver
17.3 Liver Diseases
17.4 Regeneration of the Liver
17.5 Liver Tissue Engineering and 3D Bioprinting
17.6 3D-Bioprinted Liver Tissues
17.7 Challenges and Future Perspectives
Acknowledgments
Questions
References
Chapter 18. Organ Printing
Abstract
18.1 Introduction
References
Chapter 19. 3D Bioprinting, Nanotechnology, and Intellectual Property
Abstract
19.1 Introduction
19.2 Why is Intellectual Property Important?
19.3 Types of Intellectual Property
19.4 Where Does Intellectual Property Law Originate?
19.5 What Aspects of 3D Bioprinting and Nanotechnology are Protectable?
19.6 Intellectual Property Protection Limitations for Engineered Tissue
19.7 Ethical Considerations of Engineered Tissue Intellectual Property
19.8 Intellectual Property Infringement
19.9 Conclusion
Questions
Answers to Questions
Index
No. of pages: 562
Language: English
Published: February 18, 2022
Imprint: Academic Press
Hardback ISBN: 9780128245521
eBook ISBN: 9780128245538
LZ
Lijie Grace Zhang
Dr. Zhang is the Director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering. Her research interests include 3D/4D bioprinting, nanotechnology, complex tissue engineering, cancer metastasis model, and soft bio-robotics. She is a Fellow of the American Institute for Medical and Biological Engineering and has received many prestigious awards including NIH Director’s New Innovator Award. Dr. Zhang is currently the Editor-in-Chief of Biomedical Engineering Advances and Associate Editors for several high-impact international journals.
Affiliations and expertise
Professor and Associate Dean for Research, School of Engineering and Applied Science, The George Washington University, USA
KL
Kam Leong
Dr. Leong is the Director of Nanotherapeutics and Stem Cell Engineering Laboratory. His research focuses on the development of innovative biomaterials for drug and delivery, nonviral gene editing, and regenerative medicine. He is a member of the National Academy of Engineering, National Academy of Medicine, and National Academy of Inventors, and the Editor-in-Chief of Biomaterials.
Affiliations and expertise
Samuel Y. Sheng Professor, Department of Biomedical Engineering, Columbia University
JF
John P. Fisher
Dr. Fisher is the Director of the Tissue Engineering and Biomaterials Laboratory and investigates biomaterials, stem cells, and bioreactors for the regeneration of lost tissues, particularly bone, cartilage, vasculature, and skeletal muscle. In 2012 Dr. Fisher was elected Fellow of the American Institute for Medical and Biological Engineering. Dr. Fisher is currently the co-Editor-in-Chief of the journal Tissue Engineering.
Affiliations and expertise
Fischell Family Distinguished Professor and Chair, Fischell Department of Bioengineering, University of Maryland