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3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine

2nd Edition - February 18, 2022

Editors: Lijie Grace Zhang, Kam Leong, John P. Fisher

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 2 4 5 5 2 - 1

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 2 4 5 5 3 - 8

3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their… Read more

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3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their industrial applications. Sections cover 4D Printing Smart Multi-responsive Structure, Cells for Bioprinting, 4D Printing Biomaterials, 3D/4D printing functional biomedical devices, 3D Printing for Cardiac and Heart Regeneration, Integrating 3D printing with Ultrasound for Musculoskeletal Regeneration, 3D Printing for Liver Regeneration, 3D Printing for Cancer Studies, 4D Printing Soft Bio-robots, Clinical Translation and Future Directions.

The book's team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application. The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs. This book provides an overview of these technologies and their integration.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Part I: Principles
Chapter 1. Nanotechnology: A Toolkit for Cell Behavior
Abstract
1.1 Introduction
1.2 Nanobiomaterials for Tissue Regeneration
1.3 3D Nano/Microfabrication Technology for Tissue Regeneration
1.4 Conclusion and Future Directions
Acknowledgments
Questions
References
Chapter 2. Bioprinting of Biomimetic Tissue Models for Disease Modeling and Drug Screening
Abstract
Graphical Abstract
2.1 Introduction
2.2 Current 3D Bioprinting Approaches to Build Biomimetic Tissue Models
2.3 Drug Screening and Disease Modeling Applications in Various Organs
2.4 Challenges and Future Outlook
Acknowledgments
Declaration of Interests
References
Chapter 3. 3D Bioprinting Techniques
Abstract
3.1 Introduction
3.2 Definition and Principles of 3D Bioprinting
3.3 3D Bioprinting Technologies
3.4 Challenges and Future Development of 3D Bioprinting
3.5 Conclusion
References
Chapter 4. The Power of CAD/CAM Laser Bioprinting at the Single-Cell Level: Evolution of Printing
Abstract
4.1 Introduction
4.2 Basics of Laser-Assisted Printing: Overview of Systems and Critical Ancillary Materials
4.3 Matrix-Assisted Pulsed-Laser Evaporation Direct-Write Mechanistics
4.4 Postprocessing Cell Viability and Function
4.5 Case Studies and Applications Illustrating the Importance of Single-Cell Deposition
4.6 Conclusion
References
Chapter 5. Laser Direct-Write Bioprinting: A Powerful Tool for Engineering Cellular Microenvironments
Abstract
5.1 Introduction
5.2 Materials in Laser Direct-Write
5.3 Laser Direct-Write Applications in 2D
5.4 Laser Direct-Write Applications in 3D
5.5 Conclusions and Future Directions
Acknowledgments
Questions
References
Chapter 6. Bioink Printability Methodologies for Cell-Based Extrusion Bioprinting
Abstract
6.1 Introduction
6.2 Definition of Printability
6.3 Relationships Between Printing Outcomes and Rheological Properties
6.4 Relationships Between Printing Outcomes and Process Parameters
6.5 Models for Printability
6.6 Current Limitations
6.7 Conclusion
Acknowledgments
Questions
References
Chapter 7. Hydrogels for Bioprinting
Abstract
7.1 Hydrogels in Bioprinting
7.2 Considerations for Using Hydrogel in Bioprinting
7.3 Strategies Used in Hydrogel-Based Bioprinting
7.4 Perspective and Outlook
References
Chapter 8. 4D Printing: 3D Printing of Responsive and Programmable Materials
Abstract
8.1 Introduction
8.2 Responsive and Programmable Materials for 4D Printing
8.3 Realization of 4D Printing
8.4 Applications of 4D Printing
8.5 Conclusion and Prospective
Questions
References
Part II: Applications: Nanotechnology and 3D Bioprinting for Tissue/Organ Regeneration
Chapter 9. Blood Vessel Regeneration
Abstract
9.1 Introduction
9.2 Cell-Free Scaffolds
9.3 Cell-Based Scaffolds
9.4 Comparison of the Technologies
9.5 Future Directions
Acknowledgments
References
Chapter 10. 3D Printing and Patterning Vasculature in Engineered Tissues
Abstract
10.1 Introduction
References
Chapter 11. Craniofacial and Dental Tissue
Abstract
11.1 Introduction
11.2 Clinical Need for Craniofacial and Dental Regenerative Medicine
11.3 Craniofacial and Dental Regenerative Medicine Research
11.4 Bone Tissue Engineering Strategies
11.5 Conclusions
Acknowledgment
References
Chapter 12. 3D Printing for Craniofacial Bone Regeneration
Abstract
12.1 Introduction
12.2 Anatomy and Mechanics of Craniofacial Bone
12.3 Materials for Craniofacial Scaffold
12.4 3D-Printing Techniques for Craniofacial Scaffold
12.5 Enhancing the Regenerative Capability of Biomaterials in Craniofacial Bone Regeneration
12.6 Case Studies: Application of Porous Scaffold Design for Clinical Applications
12.7 Conclusion
References
Chapter 13. Additive Manufacturing for Bone Load Bearing Applications
Abstract
13.1 Need for Bone Substitutes
13.2 Compositional, Structural and Mechanical Properties of Bone
13.3 Difficulties in Achieving an Ideal Bone Substitute
13.4 Metallic Bone Substitutes
13.5 Bioceramic Bone Substitutes
13.6 Nanocomposite Bone Substitutes
13.7 Conclusions
References
Chapter 14. 3D Printing of Cartilage and Subchondral Bone
Abstract
14.1 Background
14.2 Applications of 3D Printing
14.3 Major Challenges and Pitfalls
14.4 Future Directions
Acknowledgments
References
Chapter 15. Bioprinting for Skin
Abstract
15.1 Skin, Skin Substitutes, Possible Applications for Printed Skin
15.2 Skin Substitutes, Applications for Printed Skin
15.3 Skin Substitutes Generated by Bioprinting
15.4 Discussion of the Different Bioprinting Techniques and Clinical Applicability
15.5 Conclusion
Acknowledgments
References
Chapter 16. Nanotechnology and 3D/4D Bioprinting for Neural Tissue Regeneration
Abstract
16.1 Introduction
16.2 Nanotechnology for Neural Tissue Regeneration
16.3 3D/4D Bioprinting for Neural Tissue Regeneration
16.4 Conclusion and Future Directions
Acknowledgments
Questions
References
Chapter 17. 3D Bioprinting for Liver Regeneration
Abstract
17.1 Introduction
17.2 Structural and Functional Complexity of the Liver
17.3 Liver Diseases
17.4 Regeneration of the Liver
17.5 Liver Tissue Engineering and 3D Bioprinting
17.6 3D-Bioprinted Liver Tissues
17.7 Challenges and Future Perspectives
Acknowledgments
Questions
References
Chapter 18. Organ Printing
Abstract
18.1 Introduction
References
Chapter 19. 3D Bioprinting, Nanotechnology, and Intellectual Property
Abstract
19.1 Introduction
19.2 Why is Intellectual Property Important?
19.3 Types of Intellectual Property
19.4 Where Does Intellectual Property Law Originate?
19.5 What Aspects of 3D Bioprinting and Nanotechnology are Protectable?
19.6 Intellectual Property Protection Limitations for Engineered Tissue
19.7 Ethical Considerations of Engineered Tissue Intellectual Property
19.8 Intellectual Property Infringement
19.9 Conclusion
Questions
Answers to Questions
Index