Veterinary Immunology

1. Immunoglobulin isotypes, structure and function. The isotypic, allotypic and idiotypic heterogeneity of bovine IgG2. (J.E. Butler et al.) Isolation of genes encoding bovine IgM, IgG, IgA and IgE chains (K.L. Knight, R.S. Becker). The application of hybridoma technology to the study of bovine immunoglobulins (R.A. Goldsby et al.). The structure of bovine secretory component (D. Beale). The transfer of serum IgG antibody into the gastrointestinal tract in newborn calves (T.E. Besser et al.). Chicken immunoglobulins (H. Ambrosius, D. Hadge). Characterization of a homogeneous paraprotein from a horse with spontaneous multiple myeloma syndrome (R.K. Seide et al.). The subclass heterogeneity of pig IgG (F. Franek). 2. Markers of immune system cells. Lymphocyte antigens of sheep: Identification and characterization using a panel of monoclonal antibodies (C.R. Mackay et al.). The ontogeny of various cell populations defined by monoclonal antibodies in the primary lymphoid organs of sheep (M. Miyasaka). Phenotypic and functional characteristics of bovine T lymphocytes (A.J. Teale et al.). Bovine mononuclear phagocytic cells: Identification by monoclonal antibodies and analysis of functional properties (J.A. Ellis et al.). Phenotypic and functional characterization of pig lymphocyte populations (J.K. Lunney, M.D. Pescovitz). 3. Modulation of immune response and related functions. Adjuvants (K. Dalsgaard). Potentiation of the immune response by immunization with antigens in defined multimeric physical forms (B. Morein). Regulation of immunity by anti-idiotypic antibodies (H. Wigzell). Lymphokines in the regulation of immune responses (G.V. Alm). Bovine interleukin 2: Regulatory mechanisms (N.S. Magnuson et al.). Bovine interleukin 2: Cloning, high level expression and purification (P.E. Baker). 4. The major histocompatibility gene complex. Structure and expression of class I MHC genes in the miniature swine (D.S. Singer et al.). The human HLA-D region - A summary (J. Trowsdale). Biochemical and molecular analysis of sheep MHC class II Molecules (N.K. Puri et al.). The MHC of the chicken, genomic structure, gene products and resistance to oncogenic DNA and RNA viruses (M. Simonsen). Effector and regulatory T cells involved in the immune response to allografts (S.M. Stepkowski, W.R. Duncan). 5. Gene transfer technology in immunology. Transgenic mice in immunological research (R.M. Petters). Expression of rabbit IgA heavy chain genes in E. coli and in murine myeloma cells (K.L. Knight et al.). Transfection of genes encoding lymphocyte differentiation antigens: Applications in veterinary immunology (P.A. Lalor et al.). Progress on gene transfer in farm animals (V.G. Pursel et al.). 6. Advances in immunology of metazoan and protozoan infections. Nematode antigens in protection, diagnosis and pathology (R.M.E. Parkhouse et al.). The role of antibody in natural resistance to African trypanosomiasis (M. Pinder et al.). Immunity to eimeria infections (M.E. Rose). Immunochemical studies on the antigens of Dirofiliaria immitis (S.A. Fuller et al.). 7. Immunity at mucosal surfaces. Perspectives in mucosal immunity: A ruminant model (A.J. Husband). The intestinal and mammary immune system in pigs (H. Salmon). Synergism between antibody and neutrophils in the ruminant mammary gland (D.L. Watson). Immune response of cattle to respiratory mycoplasmas (C.J. Howard et al. ). Immune response to dietary antigens and its influence on disease susceptibility in farm animals (C.R. Stokes et al.). Development of nasal, fecal and serum isotype-specific antibodies in calves challenged with bovine coronavirus or rotavirus (L.J. Saif). 8. New trends in immunodiagnostics. Enzyme immunoassay: Observations on aspects of quality control (P. Wright). Rapid detection of viral-specific antibodies by enzyme-linked immunosorbent assay (ELISA) (S. Winston et al.). 9. The immune response to viral antigens as a determinant of arthritis in caprine arthritis-encephalitis virus infection (T.C. McGuire). Establishment of central nervous system infection by canine distemper virus: Breach of the blood-brain barrier and facilitation by antiviral antibody (S. Krakowka et al.). Aspects of the immunopathogenesis of flea allergy dermatitis in dogs (R.E. Halliwell et al.). Immunologic reconstitution of foals with combined immunodeficiency (L.E. Perryman et al.). Author index. Subject index.