Advances in Metabolic Disorders, Supplement 2: Vascular and Neurological Changes in Early Diabetes covers knowledge of the vascular and neurological changes in early diabetes. The book discusses the prevalence of macroangiopathy in asymptomatic diabetes, the prevalence of asymptomatic diabetes in human atherosclerosis, and the observations made in seeking evidence for macroangiopathy, microangiopathy, and neurological changes in patients with latent diabetes. The text also describes angiopathy and neuropathy in mild juvenile diabetes; the role of insulin in the development of atherosclerosis; and the effect of insulin on lipid metabolism of human arteries. Discussions about microangiopathy, including topics on serum glycoprotein disturbances and their rheological effects in diabetes mellitus; the biochemical properties of human glomerular basement membrane in normal and diabetic kidneys; and the plasma levels of growth hormone and glucagon in diabetic patients and relatives of diabetic patients are also considered. The book further tackles topics about neuropathy, including the role of sorbitol pathway in neuropathy, the polyol pathway in the neuropathy of early diabetes, as well as nervous abnormalities in early diabetes. The text concludes by looking into the effect of treatment on diabetes. Endocrinologist, biochemists, physiologists, and researchers working on related topics will find the book useful.