Limited Offer
Vascular and Neurological Changes in Early Diabetes
Advances in Metabolic Disorders, Vol. 2
- 1st Edition - October 22, 2013
- Editors: Rafael A. Camerini-Dávalos, Harold S. Cole
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 2 1 2 - 9
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 5 5 5 - 6
Advances in Metabolic Disorders, Supplement 2: Vascular and Neurological Changes in Early Diabetes covers knowledge of the vascular and neurological changes in early diabetes. The… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteAdvances in Metabolic Disorders, Supplement 2: Vascular and Neurological Changes in Early Diabetes covers knowledge of the vascular and neurological changes in early diabetes. The book discusses the prevalence of macroangiopathy in asymptomatic diabetes, the prevalence of asymptomatic diabetes in human atherosclerosis, and the observations made in seeking evidence for macroangiopathy, microangiopathy, and neurological changes in patients with latent diabetes. The text also describes angiopathy and neuropathy in mild juvenile diabetes; the role of insulin in the development of atherosclerosis; and the effect of insulin on lipid metabolism of human arteries. Discussions about microangiopathy, including topics on serum glycoprotein disturbances and their rheological effects in diabetes mellitus; the biochemical properties of human glomerular basement membrane in normal and diabetic kidneys; and the plasma levels of growth hormone and glucagon in diabetic patients and relatives of diabetic patients are also considered. The book further tackles topics about neuropathy, including the role of sorbitol pathway in neuropathy, the polyol pathway in the neuropathy of early diabetes, as well as nervous abnormalities in early diabetes. The text concludes by looking into the effect of treatment on diabetes. Endocrinologist, biochemists, physiologists, and researchers working on related topics will find the book useful.
List of Contributors
Preface
Acknowledgments
I. Macroangiopathy
Macroangiopathy—Its Prevalence in Asymptomatic Diabetes
The Prevalence of Asymptomatic Diabetes in Human Atherosclerosis
A Search for Macroangiopathy in Patients with Latent Diabetes
Angiopathy and Neuropathy in Mild Juvenile Diabetes
Discussion
The Role of Insulin in the Development of Atherosclerosis
Effect of Insulin on Lipid Metabolism of Human Arteries
Glucose Lipogenesis in Rabbit Aorta in Relation to Age, Degree of Atherosclerosis, and the Presence of Insulin
Discussion
Hypertriglyceridemia in Early Diabetes
Altered Carbohydrate and Lipid Metabolism and Coronary Heart Disease among Men in Tecumseh, Michigan
Insulin, Glucose and Lipid Levels in Mild Diabetics in Relation to Complications
Invited Discussants
Discussion
Studies in the Functional Properties of Vascular Mucopolysaccharides
Proline Hydroxylase in Injury-Induced Arteriosclerosis
Polyol Pathway Activity in Aorta
Invited Discussant
Discussion
Diabetic Macroangiopathy: Blood Flow and Radiological Studies
Discussion
II. Microangiopathy
Genetic Transmission of Vasculopathy in KK Mice
Discussion
The Metabolism of the Isolated Renal Glomerulus and Its Basement Membranes
Serum Glycoprotein Disturbances and their Rheological Effects in Diabetes Mellitus
Discussion
Biochemical Properties of Human Glomerular Basement Membrane in Normal and Diabetic Kidneys
Biochemistry of the Glomerular Basement Membrane in Diabetes
Discussion
Growth Hormone and Diabetic Angiopathy
Comparative Metabolic and Clinical Studies of Sexual Ateliotic Dwarfs and Diabetics
Plasma Levels of Growth Hormone and Glucagon in Diabetic Patients and Relatives of Diabetic Patients
Discussion
Plasma Epinephrine and Plasma Norepinephrine Concentrations in Early Diabetes
Discussion
Microangiopathy and Early Diabeticlike Sugar Tolerances in Animals with Induced Thyroid Immunity
Microangiopathy in the Experimentally Diabetic Animal
Vascular Changes Accompanying Dysmetabolism in Rabbits
Microvascular Alterations in Chronically Streptozotocin-Diabetic Rats
Discussion
Ultrastructure of Glomerular Lesions in KK Mice
Related Factors in the Progression of Microangiopathy in KK Mice
Microangiopathy in Animals with Spontaneous Diabetes
Retinal and Renal Microangiopathy in Carp with Spontaneous Diabetes Mellitus
Invited Discussant
Discussion
Diabetic Basement Membranelike Changes Demonstrable in Perippheral Blood Lymphocytes
Ophthalmoscopic Findings and Changes in Hormonal and Metabolic Parameters in “Protodiabetes”
Kidney Structural Abnormalities in Early Diabetes
Invited Discussants
Discussion
The Capillaries of South African Diabetics in Perspective
Diabetic Microangiopathy: Electron Microscope Findings in Human Muscle
Capillary Basement Membrane Thickness in Early Diabetes
Early Capillary Basement Membrane Changes in Subjects with Diabetes Mellitus
Discussion
Deterioration of Tolerance to Glucose and Progression of the Microangiopathy: Effect of Treatment (Preliminary Report)
Microvascular Changes in Early Diabetes Mellitus
Discussion
Basement Membrane Thickening in Latent Diabetes
The Microvascular Complications of Early Diabetes in the Pima Indians
Discussion
III. Neuropathy
Role of Sorbitol Pathway in Neuropathy
The Polyol Pathway in the Neuropathy of Early Diabetes
Discussion
Nervous Abnormalities in Early Diabetes
Discussion
Ultrastructural Pathology of Peripheral Nervous System in Early Diabetes
Neurological Findings in Chemical Diabetes
Neurological Changes in Early Diabetes
Clinical Features of Peripheral Neuropathy Associated with Hypoglycemia
Invited Discussants
Discussion
IV. Effect of Treatment
Effect of Hypophysectory and Growth Hormone Treatment on the Composition of Canine Aorta
Discussion
Cardiovascular Complications in Diabetics
Discussion
Therapy of Early Diabetes: The University Group Diabetes Program
Invited Discussants
Discussion
Borderline Diabetics and their Response to Tolbutamide
Long-Term Treatment of Patients with Abnormal Intravenous Glucose Tolerance after Myocardial Infarction
Vascular Disease in Diabetes and the Effect of Oral Antidiabetic Agents
Treatment of Chemical Diabetes with Chlorpropamide and the Associated Mortality
Progress Report on the Prophylactic Use of Oral Hypoglycemic Drugs in Asymptomatic Diabetes: Neurovascular Studies
Improvement in Motor Nerve Conduction Following Treatment in Newly Diagnosed Diabetics
The Effects of Metformin on Lipid-Induced Atherosclerosis
Invited Discussants
Discussion
Subject Index
- No. of pages: 620
- Language: English
- Edition: 1
- Published: October 22, 2013
- Imprint: Academic Press
- Paperback ISBN: 9781483202129
- eBook ISBN: 9781483215556
Read Vascular and Neurological Changes in Early Diabetes on ScienceDirect