Vascular and Neurological Changes in Early Diabetes

List of Contributors

Preface

Acknowledgments

I. Macroangiopathy

Macroangiopathy—Its Prevalence in Asymptomatic Diabetes

The Prevalence of Asymptomatic Diabetes in Human Atherosclerosis

A Search for Macroangiopathy in Patients with Latent Diabetes

Angiopathy and Neuropathy in Mild Juvenile Diabetes

Discussion

The Role of Insulin in the Development of Atherosclerosis

Effect of Insulin on Lipid Metabolism of Human Arteries

Glucose Lipogenesis in Rabbit Aorta in Relation to Age, Degree of Atherosclerosis, and the Presence of Insulin

Discussion

Hypertriglyceridemia in Early Diabetes

Altered Carbohydrate and Lipid Metabolism and Coronary Heart Disease among Men in Tecumseh, Michigan

Insulin, Glucose and Lipid Levels in Mild Diabetics in Relation to Complications

Invited Discussants

Discussion

Studies in the Functional Properties of Vascular Mucopolysaccharides

Proline Hydroxylase in Injury-Induced Arteriosclerosis

Polyol Pathway Activity in Aorta

Invited Discussant

Discussion

Diabetic Macroangiopathy: Blood Flow and Radiological Studies

Discussion

II. Microangiopathy

Genetic Transmission of Vasculopathy in KK Mice

Discussion

The Metabolism of the Isolated Renal Glomerulus and Its Basement Membranes

Serum Glycoprotein Disturbances and their Rheological Effects in Diabetes Mellitus

Discussion

Biochemical Properties of Human Glomerular Basement Membrane in Normal and Diabetic Kidneys

Biochemistry of the Glomerular Basement Membrane in Diabetes

Discussion

Growth Hormone and Diabetic Angiopathy

Comparative Metabolic and Clinical Studies of Sexual Ateliotic Dwarfs and Diabetics

Plasma Levels of Growth Hormone and Glucagon in Diabetic Patients and Relatives of Diabetic Patients

Discussion

Plasma Epinephrine and Plasma Norepinephrine Concentrations in Early Diabetes

Discussion

Microangiopathy and Early Diabeticlike Sugar Tolerances in Animals with Induced Thyroid Immunity

Microangiopathy in the Experimentally Diabetic Animal

Vascular Changes Accompanying Dysmetabolism in Rabbits

Microvascular Alterations in Chronically Streptozotocin-Diabetic Rats

Discussion

Ultrastructure of Glomerular Lesions in KK Mice

Related Factors in the Progression of Microangiopathy in KK Mice

Microangiopathy in Animals with Spontaneous Diabetes

Retinal and Renal Microangiopathy in Carp with Spontaneous Diabetes Mellitus

Invited Discussant

Discussion

Diabetic Basement Membranelike Changes Demonstrable in Perippheral Blood Lymphocytes

Ophthalmoscopic Findings and Changes in Hormonal and Metabolic Parameters in “Protodiabetes”

Kidney Structural Abnormalities in Early Diabetes

Invited Discussants

Discussion

The Capillaries of South African Diabetics in Perspective

Diabetic Microangiopathy: Electron Microscope Findings in Human Muscle

Capillary Basement Membrane Thickness in Early Diabetes

Early Capillary Basement Membrane Changes in Subjects with Diabetes Mellitus

Discussion

Deterioration of Tolerance to Glucose and Progression of the Microangiopathy: Effect of Treatment (Preliminary Report)

Microvascular Changes in Early Diabetes Mellitus

Discussion

Basement Membrane Thickening in Latent Diabetes

The Microvascular Complications of Early Diabetes in the Pima Indians

Discussion

III. Neuropathy

Role of Sorbitol Pathway in Neuropathy

The Polyol Pathway in the Neuropathy of Early Diabetes

Discussion

Nervous Abnormalities in Early Diabetes

Discussion

Ultrastructural Pathology of Peripheral Nervous System in Early Diabetes

Neurological Findings in Chemical Diabetes

Neurological Changes in Early Diabetes

Clinical Features of Peripheral Neuropathy Associated with Hypoglycemia

Invited Discussants

Discussion

IV. Effect of Treatment

Effect of Hypophysectory and Growth Hormone Treatment on the Composition of Canine Aorta

Discussion

Cardiovascular Complications in Diabetics

Discussion

Therapy of Early Diabetes: The University Group Diabetes Program

Invited Discussants

Discussion

Borderline Diabetics and their Response to Tolbutamide

Long-Term Treatment of Patients with Abnormal Intravenous Glucose Tolerance after Myocardial Infarction

Vascular Disease in Diabetes and the Effect of Oral Antidiabetic Agents

Treatment of Chemical Diabetes with Chlorpropamide and the Associated Mortality

Progress Report on the Prophylactic Use of Oral Hypoglycemic Drugs in Asymptomatic Diabetes: Neurovascular Studies

Improvement in Motor Nerve Conduction Following Treatment in Newly Diagnosed Diabetics

The Effects of Metformin on Lipid-Induced Atherosclerosis

Invited Discussants

Discussion

Subject Index