The Hypertensive Vascular Crisis

PrefacePart 1 The Clinical Problem Introduction The Hypertension Hypertension and the Kidney Essential Hypertension Renal Hypertension Malignant Hypertension The vascular Crisis The Symptoms of the Crisis The Cause of the SymptomsPart II The Experimental Evidence Goldblatt's Experiment Unilateral Renal Hypertension in the Rat Changes in the 'Clipped' Kidney Changes in the Untouched Opposite Kidney The Vicious Circle in Chronic Hypertension The Effect of Pregnancy on Experimental Hypertension The Reversibility of Chronic Hypertension The Vascular Crisis in Experimental Hypertension The 'Clinical' Picture The Effect of Treatment Aggravating Factors The Pathogenesis of the Crisis Structural Lesions Cerebral Edema The Nature and Distribution of the Cerebral Edema Edema in Other Tissues The Caliber of the Cerebral Arteries The Working Hypothesis StatedPart III The Hypothesis Tested The Changes in Vascular Caliber Re-Examined The Intestinal Arteries The Retinal Arterioles The Cerebral Arteries Re-Examined The Cause of the Changes in Arterial Caliber The Possible Effect of the Changes in Caliber Excessive Dilatation Excessive Constriction The Structural Lesions Re-Examined The Causation of Arterial Necrosis Are the Lesions Caused by the Hypertension? 'Atypical' Arterial Necrosis Causes of 'Atypical' Arterial Necrosis The Significance of 'Atypical' Arterial Necrosis 'Atypical' Arterial Necrosis in Cerebral Crises 'Atypical' Arterial Necrosis in Early Goldblatt Hypertension How Does Hypertension Cause Arterial Necrosis? Excessive Constriction Excessive Dilatation The Vulnerability of Weakened Arteries The Protective Effect of Medial Hypertrophy The 'Sensitizing' Effect of X Irradiation Extrusion of Plasma Giese's Experiments Are Other Factors Concerned in Causing Necrosis? Uremia 'Spontaneous' Vascular Disease Enzyme Factors Vasculo-Toxic and 'Permeability' FactorsContentsSummary The Causation of Associated Lesions Endarteritis fibrosa Capillary Glomerular Aneurysms and Focal Necroses The Effects of Hypertensive Arterial Lesions The Focal Edema Re-Examined The Cause of Focal Edema Is High Pressure the Cause of the Edema ? How does High Pressure Cause the Edema ? Are Other Factors Concerned? 'Permeability' Factors Permeability Factors in Renal Extracts Ligature of Renal Arteries Ligature of Ureters Constriction of Renal Arteries Saline Loading Renin and the 'Permeability' Factor 'Permeability' Changes in Unilateral Renal Hypertension High Blood Pressure as the 'Permeability' Factor The Effects of Hypertensive Focal Edema The Weaknesses of the Working HypothesisThe Thesis RestatedConclusion