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Books in Pharmaceutical sciences

Elsevier's Pharmaceutical Science collection helps pharmaceutical scientists striving to optimize drug design and improve healthcare outcomes by offering comprehensive coverage of every aspect of drug development, integrating disciplines like organic chemistry, biology, and biotechnology. Focused on safety, efficacy, and formulation design, it includes specialized fields such as Clinical Pharmacology and Translational Research, providing valuable insights into the latest advancements in drug discovery.

31-40 of 365 results in All results

Design and Applications of Microneedles in Drug Delivery and Therapeutics

  • 1st Edition
  • June 28, 2024
  • Prashant Kesharwani
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 3 8 8 1 - 2
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 8 8 0 - 5
Design and Applications of Microneedles in Drug Delivery and Therapeutics details the design, characterization, and applications of this novel drug delivery system. Microneedles offer several advantages over traditional oral and parenteral approaches due to their ability to be fabricated and altered in shape, size and material type, and their convenience to be matched to specific treatment needs. This book covers the materials selection, design and fabrication approaches, and clinical translation of microneedles for a range of therapeutic applications, including cancer therapy, gene and vaccine delivery, wound healing, and more.This book is a forward-thinking resource for those working in the development of materials and devices for novel drug delivery.

Biochemical and Molecular Pharmacology in Drug Discovery

  • 1st Edition
  • June 26, 2024
  • Mithun Rudrapal + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 6 0 1 3 - 4
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 6 0 1 4 - 1
Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches, along with certain key topics related to molecular pharmacology of drugs and therapeutics. The book explains the phenomena of drug-target interactions, considering different biochemical systems and cellular strategies. With the advent of technologies, current advances, and research trends move toward molecular and/or target-based drug design and discovery. Through this book, readers will gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology in a comprehensive and systematic manner.Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology.

Therapeutic Monoclonal Antibodies: From Lot Release to Stability Testing

  • 1st Edition
  • June 4, 2024
  • Harleen Kaur
  • English
  • Paperback
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  • eBook
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Therapeutic Monoclonal Antibodies: From Lot Release to Stability Testing is a highly topical resource on a subject of interest for scientists and researchers working on monoclonal antibodies' characterization, release testing, stability testing and similarity assessments of monoclonal antibodies in the biopharmaceutical industry. Monoclonal antibodies (mAbs) are large, extremely complex and dynamic biomolecules, so it can be challenging to develop well-characterized therapeutic antibodies that meet regulatory expectations that are also in-line with commercialized standards for different drug markets.Lot release testing and understanding the stability of the mAb over a period of time, and in different environmental conditions, is an indispensable aspect of mAb physicochemical characterization. This book covers the process, including extensive analysis that starts with quantifying the purity attribute to glycan profiling and identifying the mAb primary structure. The book has a primary purpose of focusing on both Lot release testing and stability testing of monoclonal antibodies (subjects not covered in any great detail in other books).

Cancer Therapy

  • 1st Edition
  • May 24, 2024
  • Surendra Nimesh + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 5 4 0 1 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 4 0 2 - 7
Cancer Therapy: Potential Applications of Nanotechnology provides readers with a compendium of all the latest research work in cancer therapeutics, including an emphasis on work in nanotechnology and polymeric nanoparticles. While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology, especially those with an emphasis on polymeric nanoparticles in cancer therapy. This title enlightens researchers and students and provides exhaustive knowledge on the topics covered.

An Integrated Guide to Human Drug Metabolism

  • 1st Edition
  • May 13, 2024
  • Mark Ashton + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 9 1 3 3 - 9
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 3 7 5 - 3
An Integrated Guide to Human Drug Metabolism: From Basic Chemical Transformations to Drug-Drug Interactions uses the chemistry of each of the metabolic transformations to underpin the discussion of drug interactions with foods, herbal medicines, and other drugs. Each of the human metabolic processes are covered, employing examples drawn from known metabolic transformations of drugs used clinically. The clinical relevance of metabolism is discussed, focusing on appropriate prescribing (age-related dosage adjustments, routes of administration, and personalized medicines). Appropriate for use in the classroom or for self-study, this book is for students and researchers needing a reference for interdisciplinary research in drug interactions.Metabolism is at the center of personalized medicine, as it is a governing factor in the response of the patient to a drug. For example, does the patient express the genes, and so enzymes, which are responsible for the metabolism of a drug? Do they express the genes responsible for the bioactivation of a prodrug into its active form? Examples of clinically used agents for which metabolic phenotyping is essential will be used to highlight the increasing necessity for understanding the genetic profile of individual patients. This book includes questions and answers to gauge learning of each chapter, real-life case studies, and the basic science as a basis for the discussion of clinical aspects.

Reproducibility in Biomedical Research

  • 2nd Edition
  • April 26, 2024
  • Erwin B. Montgomery Jr.
  • English
  • Paperback
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  • eBook
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Reproducibility in Biomedical Research: Epistemological and Statistical Problems, Second Edition explores the ideas and conundrums inherent in scientific research. This second edition addresses new challenges to reproducibility in biosciences, namely reproducibility of machine learning Artificial Intelligence (AI), reproducibility of translation from research to medical care, and the fundamental challenges to reproducibility. All current chapters are expanded to cover advances in the topics previously addressed. This book provides biomedical researchers with a framework to better understand the reproducibility challenges in the area. Newly introduced interactive exercises and updated case studies help students understand the fundamental concepts involved in the area.

Liposomes in Drug Delivery

  • 1st Edition
  • April 10, 2024
  • Sophia G. Antimisiaris
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 5 4 9 1 - 1
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 4 9 2 - 8
Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/characterize/investigate/optimize liposome properties for a particular application.The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvantages, and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/technologies for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication.

Novel Formulations and Future Trends

  • 1st Edition
  • March 25, 2024
  • Amit Kumar Nayak + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 8 1 6 - 9
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 7 2 4 5 - 1
Novel Formulations and Future Trends, Volume Three in the Recent and Future Trends in Pharmaceutics series, explores aspects of pharmaceutics with an original approach focused on technology, novelties and future trends. It discusses the most important developments in drug delivery, including important and exciting areas such as mucosal, implantable, transdermal, gastroretentive, vaccine and targeted drug delivery systems. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. This is an essential reference for researchers in academia and industry as well as advanced graduate students.New technologies are also explored including 3D printing and computational pharmaceutics.

Concepts and Models for Drug Permeability Studies

  • 2nd Edition
  • February 20, 2024
  • Bruno Sarmento + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 5 5 1 0 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 5 5 1 1 - 6
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs.This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route.Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models.Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

  • 3rd Edition
  • February 11, 2024
  • Ali S. Faqi
  • English
  • Hardback
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  • eBook
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A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.