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Medicinal Chemistry
A molecule and atom-level approach to drug discovery and drug action
- 1st Edition - January 1, 2026
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 1 3 7 0 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 1 3 7 1 - 4
"Medicinal Chemistry: A molecule and atom-level approach to drug discovery and drug action" provides a discussion of the basis of drug discovery and drug action at molecule and… Read more
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Request a sales quote"Medicinal Chemistry: A molecule and atom-level approach to drug discovery and drug action" provides a discussion of the basis of drug discovery and drug action at molecule and atom levels, integrated with an examination of the essentials of drug synthesis. All families of relevant drugs in therapeutic use are covered, and drugs are organized according to their targets, providing a basis for the understanding of their interference in biochemical processes. It also contains numerous illustrations focusing on drug-target interactions, structure-activity relationships and drug synthesis. Figures and summaries are often used instead of lengthy verbal descriptions to facilitate the reader capture the key points of each topic. Drug synthesis is treated from the retrosynthetic design perspective to make it more rational and appealing to readers.
• Includes explanation of drug action at molecule and atom levels in the whole field of medicinal chemistry • Analyzes the integration of drug discovery, drug action and drug synthesis • Covers chapters devoted to topics not generally found in competing books, such as drugs that modulate radical-mediated processes, therapy based on protein degradation, chemical aspects of drug preformulation and biological drugs
Advanced undergraduate students, graduate students and researchers working with Medicinal Chemistry
Chapter 1. Introduction to Medicinal Chemistry Part 1: Basic principles of drug discovery Chapter 2. Therapeutic targets Chapter 3. General aspects of drug design (1) Chapter 4. General aspects of drug design (2) Chapter 5. General aspects of drug design (3) Chapter 6. Drug metabolism (1): The chemistry of drug metabolism Chapter 7. Drug metabolism (2): Chemical aspects of metabolism-associated drug toxicity Chapter 8. Prodrugs and drug delivery systems Part 2: Drugs acting as enzyme inhibitors Chapter 9. General concepts in enzyme inhibition Chapter 10. Antimetabolites Chapter 11. Drug synthesis (1) Chapter 12. Enzyme inhibitors as antivirals Chapter 13. Enzyme inhibitors as antibacterials and antifungals Chapter 14. Drug synthesis (2) Chapter 15. Pharmacodynamic drugs acting by inhibition of hydrolytic enzymes Chapter 16. Pharmacodynamic drugs acting by inhibition of redox enzymes Chapter 17. Miscellaneous pharmacodynamic enzyme inhibitors Chapter 18. Drug synthesis (3) Part 4: Drugs acting at membrane receptors Chapter 19. Drugs that modulate ion channels and ion transport Chapter 20. Drugs that modulate the cholinergic system Chapter 21. Drugs that modulate the adrenergic system Chapter 22. Drugs that modulate the dopamine, serotonin and melatonin systems Chapter 23. Drug synthesis (4) Chapter 24. Drugs that modulate amino acid receptors Chapter 25. Drugs that modulate peptide receptors Chapter 26. Drugs that modulate histamine receptors Chapter 27. Drugs that modulate adenosine and ADP receptors Chapter 28. Drug synthesis (5) Chapter 29. Drugs that modulate nuclear receptors (1). Steroid hormones Chapter 30. Drug synthesis (6) Chapter 31. DNA and associated enzymes as drug targets Chapter 32. RNA and associated enzymes as drug targets Chapter 33. Drugs acting at signaling pathways Chapter 34. Drugs that modulate radical-mediated processes (1). Antioxidant therapy Chapter 35. Drugs that modulate radical-mediated processes (2). Chemotherapeutic agents that act by radical generation Chapter 36. Drug synthesis (7) Part 5: Special topics Chapter 37. Chemical aspects of drug preformulation Chapter 38. Protein degradation-targeted therapy Chapter 39. Biological drugs
- No. of pages: 750
- Language: English
- Edition: 1
- Published: January 1, 2026
- Imprint: Elsevier
- Paperback ISBN: 9780443313707
- eBook ISBN: 9780443313714