Intestinal Barrier in Health and Disease

Intestinal Barrier in Health and Disease: Implications for Personalized Oral Drug Delivery fills a gap in the literature on oral drug absorption and drug delivery to the gastrointestinal tract in situations where the gastrointestinal (GIT) barrier is abnormal, for example, due to disease, aging or malnutrition. Topics in the book include physiological barriers to oral drug absorption & delivery to GIT, physiological regulation of the intestinal epithelial barrier, and disease-associated (e.g. Inflammatory Bowel Disease) remodelling of the intestinal epithelial barrier and effect on oral drug bioavailability & delivery to the GIT including microbiota-associated (dysbiosis) effects on oral drug bioavailability. Also covered is malnutrition-associated effect on the intestinal epithelial barrier and effect on oral drug absorption/bioavailability age-Associated Remodeling of the intestinal epithelial barrier and effect on oral drug bioavailability. Intestinal Barrier in Health and Disease: Implications for Personalized Oral Drug Delivery will be of interest to pharmaceutical scientists working in the pharmaceutical industry and academia, as well as undergraduate and postgraduate students studying relevant biomedical sciences such as pharmacy/pharmaceutical science and medicine.