Gastrointestinal Hormones
Advances in Metabolic Disorders, Vol. 11
- 1st Edition - October 22, 2013
- Editor: Viktor Mutt
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 2 1 0 - 5
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 5 5 3 - 2
Advances in Metabolic Disorders, Volume 11: Gastrointestinal Hormones covers the developments in the study of gastrointestinal (GI) hormones. The book discusses the cytochemical… Read more

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Request a sales quoteAdvances in Metabolic Disorders, Volume 11: Gastrointestinal Hormones covers the developments in the study of gastrointestinal (GI) hormones. The book discusses the cytochemical techniques in work with GI hormones; the general aspects and problems for the radioimmunoassays of GI hormones in the 80s; and the response of the GI hormone system to the pathological changes. The text also describes the evolutional aspects of GI hormones; the cell membrane receptors for secretagogues on pancreatic acinar cells; and the synthesis of GI hormones using organic chemical or recombinant DNA techniques. Gastrin is reviewed with regard to its forms and fragments in tissues, circulating components during post- and perisecretory processing, cellular origins and distribution, actions and structure-function relations, metabolic disposal, nervous and chemical control for its release, and its role in human pathology. The book further tackles the chemical, anatomical, and biological studies on gastrin-releasing peptides, as well as the physiological actions of gastric inhibitory polypeptide. Discussions about the vasoactive intestinal peptide, incretin, enteroglucagon, neuropeptide Y, peptide HI, galanin, cholecystokinin-58, neuropeptide K, peptide YY, motilin, somatostatin-28, neurotensin, substance P, and opioid peptides are also encompassed. The text concludes by looking into the investigations on the structure and function of the head activator in hydra and in mammals. Molecular biologists, endocrinologists, histochemists, physiologists, and those involved in the research about GI hormones will find the book invaluable.
Introduction
Discussion
References
Cytochemical Techniques in Work with Gastrointestinal Hormones
I. Introduction
II. Cytochemical Methods and the Concept of the Gut as an Endocrine Organ
III. Electron Microscopy
IV. Immunocytochemistry
V. Gastrointestinal Hormone-Producing Cells
VI. General Markers for Gastrointestinal Endocrine Cells
VII. New Technology
VIII. Conclusions
References
Radioìmmunoassay Problems for Gut Hormones in the Eighties
I. Introduction
II. Structural Premises for the Assay of Gut Hormones
III. General Strategy for Measurement of Gut Hormones
IV. Production of Antibodies
V. Evaluation of Antisera
VI. Preparation of Tracers
VII. Separation Techniques
VIII. Sequence-Specific Radioimmunoassays
References
Gastrointestinal Hormones in Disease
I. Introduction
II. Effects of Age and Obesity
III. Gastric Pathology
IV. Intestinal Surgery
V. Diseases Resulting in Malabsorption
VI. Inflammation
VII. Abnormalities of the Enteric Neural System
VIII. Conclusions
References
Evolutionary Aspects of Gastrointestinal Hormones
I. Introduction
II. Methodological Approaches
III. Gut Peptides in Nerves and Elsewhere
IV. Hormonal Families
V. Overview
References
Cell Membrane Receptors for Secretagogues on Pancreatic Acinar Cells
I. Introduction
II. Receptors for Secretagogues that Cause Mobilization of Cellular Calcium
III. Receptors for Secretagogues that Increase Cellular Cyclic AMP
References
Synthesis of Gastrointestinal Hormones Using Organic Chemical or Recombinant DNA Techniques
I. Introduction
II. Synthetic Replicates of Gastrointestinal Hormones
III. Synthesis of Peptides Based on the Amino Acid Sequences Deduced from Hormone Precursor Structures
IV. Immunochemical Studies on Gastrointestinal Hormones Using Synthetic Replicates, Fragments, and Analogs
V. Structure-Activity Study
VI. Synthesis of Gastrointestinal Hormones by Recombinant DNA Techniques
References
Gastrin
I. Forms and Fragments of Gastrin in Tissues
II. Circulating Components: Post- and Perisecretory Processing
III. Cellular Origins and Distribution
IV. Actions of Gastrin
V. Structure-Function Relations
VI. Metabolic Disposal of Gastrin
VII. Nervous and Chemical Control of Gastrin Release
VIII. Gastrin in Human Pathology
References
The Gastrin-Releasing Polypeptide (GRP)
I. Introduction
II. Chemical Studies
III. Anatomical Studies
IV. Biological Studies
V. Summary
References
Secretin and Cholecystokinin
I. Secretin
II. Cholecystokinin
III. Conclusions
References
Gastric Inhibitory Polypeptide (GIP)
I. Isolation and Structure of GIP
II. Cellular Localization
III. Secretion of IR-GRP
IV. Obesity
V. Insulin-Dependent Diabetes
VI. Non-Insulin-Dependent Diabetes
VII. Physiological Actions of GIP
References
The Incretin Concept
I. The Enteroinsular Axis and Its Neural Components
II. Definition of Incretin
III. The Incretin Candidates
IV. GIP Response in Malassimilation Syndromes
V. GIP Response to Oral Fat
VI. Insulinotropic Effects of GIP
VII. GIP in Diabetes Mellitus
Vili. GIP Secretion in Obesity
IX. Quantification of Incretin
X. Evidence for Further Incretins
XI. Significance of Altered Hepatic Insulin Extraction
XII. Conclusion
References
Vasoactive Intestinal Peptide
I. Discovery and Isolation from Intestine
II. Rediscovery as a Neuropeptide
III. Distribution and Localization
IV. Chemical Structure and the Family of Related Peptides
V. Biosynthesis and Molecular Biology
VI. Chemical Synthesis
VII. Structural Variants in the Animal Kingdom
VIII. Biological Actions
IX. Mechanism of Action
X. Release
XI. Pharmacokinetics and Metabolism
XII. Interactions with Other Hormones and Neurotransmitters
XIII. Physiological Roles
XIV. Relationship to Human Disease
XV. Potential as a Therapeutic Agent
References
Enteroglucagon
I. Introduction
II. Chemistry
III. Localization of Enteroglucagon
IV. Enteroglucagon Secretion
V. Circulating Enteroglucagon
VI. Effects of Enteroglucagon
VII. Conclusion
References
Neuropeptide Y, Peptide HI, Galanin, Cholecystokinin-58, Neuropeptide K, and Peptide YY
I. Introduction
II. Neuropeptide Y
III. Peptide HI
IV. Galanin
V. Cholecystokinin-58
VI. Neuropeptide K
VII. Peptide YY
VIII. Summary
References
Motilin
I. Isolation and Structure of Motilin
II. Cellular Localization
III. The Secretion of Motilin and Its Effect on Gastrointestinal Motility and Exocrine Secretion
IV. Mode of Action of Motilin on Smooth Muscle
V. Actions of Motilin on Central Neurons and the Pituitary
VI. Clinical Aspects
References
Somatostatin-28
I. Introduction
II. Isolation, Synthesis, and Biochemical Properties
III. Distribution
IV. Biological Effects
V. Conclusion
References
Neurotensin and Substance P
I. Neurotensin
II. Substance P
References
Opioid Peptides and the Gastrointestinal Tract
I. The Opioid Peptide Systems
II. Immunohistochemical Distribution of Opioid Peptides
III. Functional Aspects
IV. Concluding Remarks
References
Structure and Function of the Head Activator in Hydra and in Mammals
I. Introduction
II. Isolation and Sequence Analysis of the Head Activator
III. Immunoassays
IV. Effects of the Head Activator on Cellular Growth and Differentiation in Hydra
V. Action of the Head Activator in Mammals
VI. Head Activator in Plasma Is Carrier-Bound
VII. Summary
References
Index
- No. of pages: 556
- Language: English
- Edition: 1
- Published: October 22, 2013
- Imprint: Academic Press
- Paperback ISBN: 9781483202105
- eBook ISBN: 9781483215532
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