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Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new dr… Read more
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Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors.
Medicinal Chemists working in drug discovery and synthetic organic chemists. Also those in the Pharma industry, working to streamline costs and design more efficient reactions
1. Introduction: Origin, Genesis and Relevance of Domino Reactions
2. Asymmetric Domino Reactions
3. Metal-Catalyzed Domino Reactions
4. Enzymatic Domino Processes
5. Heterocyclic Domino Reactions
6. Domino Reactions in the Synthesis of Target Molecules
7. Domino Name Reactions
8. Enzyme-catalysed Domino Reactions in Pharmaceutical Perspective
9. Case Studies of Coupled Name Reactions
10. Conventional route of synthesis as per product patent of drug
11. Comparison between DNR and conventional RoS [Route of Synthesis]
12. Applications of Domino Reactions in Chiral Drug Design
13. References and Suggested Readings: Literature Review including Patents
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