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Conjugates of Steroid Hormones
1st Edition - January 1, 1969
Authors: Harry E. Hadd, Robert T. Blickenstaff
9 7 8 - 1 - 4 8 3 2 - 6 3 4 5 - 8
Conjugates of Steroid Hormones focuses on the synthesis, isolation, assay, and metabolism of steroid conjugates. The book first offers information on the isolation of steroid… Read more
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Conjugates of Steroid Hormones focuses on the synthesis, isolation, assay, and metabolism of steroid conjugates. The book first offers information on the isolation of steroid conjugates and sulfates of steroid hormones. Topics include separation of steroid conjugates by adsorption, isolation from natural sources, group separation of sulfates and glucuronides, enzymic synthesis, and separation of steroid conjugates by solvent extraction. The manuscript then tackles glucuronides and glycosides of steroid hormones, as well as chemical synthesis and biosynthesis of diconjugates. The text ponders on phosphates of steroid hormones and metabolism of steroid conjugates. Discussions focus on the occurrence of steroid phosphates in biological fluids; metabolism of dehydroepiandrosterone sulfate to estrogens; formation of dehydroepiandrosterone sulfate; and estrogen conjugates. The publication is highly recommended for organic chemists and biochemists.
ContentsForeword Preface Trivial and Systematic Names of Steroids ChapteR I. Isolation of Steroid Conjugates Isolation from Natural Sources Separation of the Steroid Conjugates by Solvent Extraction Separation of the Steroid Conjugates by Adsorption Group Separation of Sulfates and Glucuronides Separation of Individual Steroid Conjugates in Each Group References Chapter II. Sulfates of Steroid Hormones Enzymic Synthesis Chemical Synthesis Synthesis of Radioactive Sulfates Explanation of Table II.2 References Table II.2 Chapter III. Glucuronides of Steroid Hormones Enzymic Glucuronylations Chemical Synthesis Explanation of Table III.3 References Table III.3 Chapter IV. Other Glycosides of Steroid Hormones Biosynthesis of Diconjugates Chemical Synthesis Explanation of Table IV.1 References Table IV.1 Chapter V. Phosphates of Steroid Hormones The Occurrence of Steroid Phosphates in Biological Fluids Chemical Synthesis of Steroid Phosphates Explanation of Table V.1 References Table V.l Chapter VI. Metabolism of Steroid Conjugates Formation of Dehydroepiandrosterone Sulfate Metabolism of Dehydroepiandrosterone Sulfate to Estrogens Estrogen Conjugates A Unified Hypothesis Concerning the Biogenesis of the Glucuronide-Sulfate Conjugated Pairs of Androsterone and Etiocholanolone Testosterone Sulfate Sulfates in the Pregnane Series Tentative Structures Artifacts References Appendix I. A Proposed System of Nomenclature for Steroid Glycosides Appendix II. Nomenclature for Phosphorus Compounds Appendix III. Fortran IV Source List Author IndexSubject Index