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Brain Metastases in Lung Cancer Patients
- 1st Edition - December 3, 2029
- Editors: Giulia M Stella, Fabio Perrotta
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 9 6 4 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 1 7 0 - 7
Brain metastases in lung cancer patients aims to provide new insights into biology and clinical management of a feared and common disease, recapitulating and dissecting the molecu… Read more
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Request a sales quoteBrain metastases in lung cancer patients aims to provide new insights into biology and clinical management of a feared and common disease, recapitulating and dissecting the molecular basis of metastatic brain dissemination from lung cancer. Lung cancer is among the leading causes of death worldwide and is frequently associated to the arousal of brain metastasis, most often discovered at diagnosis. A key role is played by liquid biopsy, as non-invasive informative tool for both diagnosis and monitoring of response to targeted therapies. Molecular mechanisms leading to tumour spreading to brain are almost unknown so that these tragic cases are still lacking effective therapies. The book looks into the epidemiology and clinical approach to brain-metastatic lung cancer, molecular basis of dissemination to the brain, and the novel therapeutic approaches. The book summarizes and analyses the pathogenic mechanisms leading to activation of scatter factor receptor in brain metastatic dissemination from the lungs within the perspective of designing less empirical treatment strategies than those currently used.
- Compiles all the novel issues regarding biology and molecularly based therapies in one reference
- Illustrates novel opportunities and technical improvements for diagnosis and response monitoring
- Multi-disciplinary approach; includes epidemiology and clinical approach to brain-metastatic lung cancer, molecular basis of dissemination to the brain, and therapeutic approaches
Pulmonologists, oncologists, molecular biologists, radiotherapists and those involved in the management of lung cancer patients featuring advanced disease
Section 1. Epidemiology and clinical approach
1. Lung cancer: a disease family featuring different embryo origin
2. Incidence of brain metastatic disease in both NSCLC and SCLC
3. Prognosis and current prognostic markers
4. Neuroimaging techniques in diagnosis of brain metastases
5. Neuropathology: how and why to differentiate primary brain tumors from metastases
6. Prognostic scores and current therapeutic approaches
Session 2. Molecular basis of dissemination to the brain
7. Biological basis of metastatic disease
8. Characterization of genetic alterations in brain metastases from lung cancer
9. Detection strategy of clinically actionable mutations not detected in primary tumor
10. The role of liquid biopsy (blood and cerebrospinal fluid)
11. Activation of invasive growth in brain metastases
Session 3. Novel therapeutic approaches
12. Limits and disappointing result of conventional chemotehrapy: why and how to move on
13. Targeting oncogenic-addicted brain lesions from NSCLC
14. The brain as immunologically privileged site
15. Immunotherapy in brain metastatic lung cancer
16. Immune modulatory effects of ionizing radiation
17. New strategies to improve radiation therapy efficacy
18. Multidisciplinary management of the disease
- No. of pages: 410
- Language: English
- Edition: 1
- Published: December 3, 2029
- Imprint: Academic Press
- Paperback ISBN: 9780128239643
- eBook ISBN: 9780128241707
GS
Giulia M Stella
Dr Giulia Maria Stella graduated in Medicine and Surgery (110/110 cum Laude) in 2001. She obtained the MD European Qualification in 2002. She obtained the Specialization in Respiratory System Diseases (50/50 cum laude). She completed the PhD in Pharmacological Sciences, University of Pavia Medical School. Thesis title: “MET somatic mutations in early metastatic cancers” (Tutors: Prof E.Pozzi, University of Pavia and Prof PM Comoglio, University of Turin) and then the Master degree in Molecular Oncology (110/110 cum laude)- Dept of Oncological Sciences, University of Turin Medical School in 2011. She is now working as Clinical Research Assistant - Pulmonology/Thoracic Oncology Unit at Fondazione IRCCS Policlinico San Matteo , Pavia and as lecturer for Respiratory System Diseases at University of Pavia Medical School. Technical skills and Clinical competences Molecular Biology: DNA cloning, sequencing, PCR, Real time PCR (Sybr and Taq Man); Cell Biology: Cell culture of mammalian cells, transient and stable transfection, single cell dilution, use of inducible promoters, virus production and cellular transduction (infection with retrovirus and lentivirus); Biochemistry: western immuno-blotting, protein kinase assay; Bioinformatics: working knowledge of various software including: Microsoft Word, Power Point, EndNote, Excel, Adobe Photoshop, Origin.; Clinical Expertise : invasive procedures (bronchoscopy, thoracoscopy, lymph nodes biopsy, thoracentesis and paracentesis); medical procedures: lung cancer patients management (involved as responsible of Thoracic Oncology section).
Affiliations and expertise
Department of Hematological, Pneumological and Cardiovascular Sciences - Section of Pneumology, University and Fondazione IRCCS Policlinico, Pavia, ItalyFP
Fabio Perrotta
Fabio Perrotta works in the Department of Translational Medical Sciences, Luigi Vanvitelli University of Campania, Naples, Italy.
Affiliations and expertise
Department of Translational Medical Sciences, Luigi Vanvitelli University of Campania, Naples, Italy