Brain Mechanisms in Mental Retardation

List of Contributors and Participants

Foreword

Welcoming Remarks

Part I Development of Neuronal Functions


1 Timing of Major Ontogenetic Events in the Visual Cortex of the Rhesus Monkey

References


2 Effects of Interference with Cerebellar Maturation on the Development of Locomotion. An Experimental Model of Neurobehavioral Retardation

References


3 Neuronal Sprouting after Hippocampal Lesions

References


4 Physiological Properties of Vertebrate Nerve Cells in Tissue Culture

References


4A Discussion: Biochemical Studies in Various Culture Systems of Neural Tissues

References


5 Synaptic and Dendritic Development and Mental Defect

References


6 Normal and Aberrant Neuronal Development in the Cerebral Cortex of Human Fetus and Young Infant

References


6A Discussion: CNS Maturation and Behavioral Development

References


6B Discussion: Development of Postsynaptic Potentials Recorded from Immature Neurons in Kitten Visual Cortex

References

Part II Role of the Basal Ganglia in Normal and Abnormal Development


7 Neurophysiological and Anatomical Interrelationships of the Basal Ganglia

References


8 Neuronal Control of Neurochemical Processes in the Basal Ganglia

References


8A Discussion: L-Dopa-Induced Improvement of Conditioned Response Inhibition

References


8B Discussion: Acetylcholine and the Caudate

References


9 Dopamine-Containing Neurons of the Substantia Nigra and Their Terminals in the Neostriatum

References


9A Discussion: Nigrostriatal Projections and the "Dopamine Receptor"

References


10 Effects of Caudate Nuclei Removal in Cats. Comparison with Effects of Frontal Cortex Ablation

References

Part III Behavioral Plasticity during Development


11 Brainstem Substrates of Sensory Information Processing and Adaptive Behavior

References


11A Discussion: Neurophysiological Substrates of Behavioral Habituation and Conditioning

References


12 Unit Recordings during Pavlovian Conditioning

References


12A Discussion: "Operant Sensitization" and Some Remarks on Unit Recording in Conscious Animals

References


13 Age, Sex, and Experience as Related to the Neural Basis of Cognitive Development

References


13A Discussion: Effects of Caudate Nuclei Removal versus Frontal Cortex Lesions in Kittens

References


14 Prenatal Nutrition and Neurological Development

References


15 The Futility of Comparative IQ Research

References

Part IV Metabolic Defects in Development


16 Hepatic Phenylalanine Hydroxylase and PKU

References


16A Discussion: Phenylalanine Hydroxylase in Human Kidney; Relevance to Phenylketonuria

References


17 Studies on the Molecular Defect in Galactosemia

References


18 The Enzymology of Tay-Sachs Disease and Its Variant Forms

References


18A Discussion: Metachromatic Leukodystrophy, an Unusual Case with a Subtle Cerebroside Sulfatase Defect

References


19 Role of Biochemistry in Research on Mental Retardation

References

Epilogue

References

Author Index

Subject Index