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Advances in Radiation Biology
Volume 8
- 1st Edition - December 28, 1979
- Editors: John T. Lett, Howard Adler
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 0 3 5 4 0 8 - 5
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 3 5 1 3 - 4
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 8 1 9 0 - 2
Advances in Radiation Biology, Volume 8, provides an overview of the state of knowledge in the field of radiation biology. The book contains nine chapters and opens with a study on… Read more
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Request a sales quoteAdvances in Radiation Biology, Volume 8, provides an overview of the state of knowledge in the field of radiation biology. The book contains nine chapters and opens with a study on aspects of oxygen enhancement ratio and relative biological effectiveness that are relevant to neutron therapy. This is followed by separate chapters on the clinical application of negative pi mesons; the clinical features and cellular and biochemical defects in human diseases, with an emphasis on defects in DNA metabolism, particularly DNA repair; recombination in eukaryotes; and the principal mechanisms of DNA damage and repair in higher plants. Subsequent chapters deal with the effect of oxygen on the repair of radiation damage by cells and tissues; the effects of ionizing radiation on mammalian cells; heritable lesions affecting populations of irradiated mammalian cells; and environmental impact of tritium.
Contributors
Contents of Other Volumes
Aspects of OER and RBE Relevant to Neutron Therapy
I. Introduction
II. Early Studies
III. The Rationale for Fast Neutron Therapy
IV. The Oxygen Effect
V. Repair after X Rays and Neutrons
VI. Relative Biological Effectiveness (RBE) for Normal Tissues
VII. Mixtures of Neutrons and X Rays
VIII. Responses of Tumors
IX. Clinical Results
X. Conclusions
References
Present Status of the Proposed Use of Negative Pi Mesons in Radiotherapy
I. Introduction
II. The Pion Proposal
III. Single-Cell Survival
IV. Somatic-Cell Mutagenesis Studies
V. Multicellular Tumor Spheroid Studies
VI. Normal versus Tumor Tissue Responses in the Laboratory
VII. Normal versus Tumor Tissue Responses in the Clinic
VIII. Summary
References
Human Diseases Associated with Defective DNA Repair
I. Introduction
II. Xeroderma Pigmentosum
III. Ataxia Telangiectasia (Louis-Bar Syndrome)
IV. Fanconis Anemia
V. The Hutchinson-Gilford Progeria Syndrome
VI. Bloom's Syndrome
VII. Cockayne's Syndrome
VIII. Down's Syndrome (Trisomy 21)
IX. Retinoblastoma
X. Chronic Lymphocytic Leukemia
XI. Miscellaneous Human Diseases with Possible DNA Repair Defects
XII. Conclusions
References
The Induction of Molecular and Genetic Recombination in Eukaryotic Cells
I. Introduction
II. Meiotic Recombination in General
III. Mitotic Recombination
IV. Mechanisms of Induced Mitotic Recombination
V. The Relation between Induced Recombination in Lower and Higher Eukaryotes
VI. Concluding Comments
References
DNA Damage and Repair in Higher Plants
I. Introduction
II. Some Features of Injury of Plants and Plant DNA by Radiation and Chemical Treatments
III. Principal Ways of Repair of DNA Damage
IV. Initial Approaches to the Study of Repair in Higher Plants
V. Photoreactivation in Higher Plants
VI. Excision Repair of Damage Induced in Plant DNA with UV-Irradiation
VII. Repair of Damage Induced in Plant DNA with Ionizing Radiation
VIII. Repair of Damage Induced in Plant DNA with Chemical Mutagens and Carcinogens
IX. Inhibition of Repair Processes in Higher Plants
X. Repair and Mutagenesis
XI. Concluding Remarks
References
The Effect of Oxygen on the Repair of Radiation Damage by Cells and Tissues
I. Introduction
II. Important Aspects of the Oxygen Effect
III. Repair in Vitro
IV. Repair in Vivo
V. Repair of Molecular Damage
References
Manifestations of Damage from Ionizing Radiation in Mammalian Cells in the Postirradiation Generations
I. Introduction
II. Cellular Effects
III. Subcellular Effects: Chromosome Aberrations
IV. Effects on the Synthesis of Macromolecules
V. Relation of the Behavior of Cells in the Postirradiation Generations to Cell Death
References
Heritable Lesions Affecting Proliferation of Irradiated Mammalian Cells
I. Introduction
II. Early Observations
III. Basic Techniques in the Study of Heritable Lesions
IV. Heritably Damaged Cells
V. Induction of Heritable Lesions by Densely Ionizing Radiations
VI. Induction of Heritable Lesions by Tritiated Compounds
VII. The Oxygen Effect
VIII. Induction of Heritable Lesions by Alkylating Agents and Other Factors
IX. Observations in Vivo
X. Heritable Lesions and Survival Determination
XI. Late Recovery
XII. Quantification of Heritably Damaged Cells on the Basis of Growth Observations
XIII. Postirradiation Intrapopulation Disturbances and Recovery
XIV. Conjectures as to the Nature of Heritable Lesions and the Mechanisms of Late Recovery
XV. Significance for Radiotherapy
XVI. Summary and Future Objectives
References
Tritium in the Environment
I. Introduction
II. Physical Characteristics
III. Sources of Tritium
IV. World Tritium Inventory
V. Metabolism of Tritium: Intake and Distribution
VI. Isotopic Effects and Transmutation
VII. Dosimetry of Tritium
VIII. Population Exposure to Tritium and Related Risks
IX. Summary
References
Subject Index
Erratum
- No. of pages: 480
- Language: English
- Edition: 1
- Published: December 28, 1979
- Imprint: Academic Press
- Hardback ISBN: 9780120354085
- Paperback ISBN: 9781483235134
- eBook ISBN: 9781483281902
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