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NanoArmored Enzymes for High Temperature Biocatalysis
1st Edition - January 1, 2020
Authors: Challa Vijaya Kumar, Rajeswari M. Kasi
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 4 5 3 5 - 7
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 4 5 3 6 - 4
NanoArmored Enzymes for High Temperature Biocatalysis provides insight on the central theme of entropy minimization for the stabilization of enzymes using linear synthetic… Read more
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NanoArmored Enzymes for High Temperature Biocatalysis provides insight on the central theme of entropy minimization for the stabilization of enzymes using linear synthetic polymers. The book describes methods for the conversion of ordinary enzymes into those that can withstand organic solvents, extreme pHs and higher temperatures. Many books written about enzyme stabilization employ a variety of hit-or-miss approaches, but rational approaches based on molecular engineering were never explored. This book addresses missing links in the field of enzyme catalysis at high temperature by exploiting the polymer encapsulation of enzymes based on a solid foundation of physical chemistry principles.
- Provides detailed explanations of the significance of enzymes in industry and academia
- Explains the limitation of enzymes under non-ambient and challenging conditions
- Includes synthesis of molecularly-engineered enzyme-polymer nanogels
- Includes applications of enzyme-polymer nanogels in biofuel cells and sensing applications
- Summarizes how the molecular engineering strategy led to solving critical problems in industrial biocatalysis
Graduate students and advanced researchers from academic/industrial background who are interested in enzyme stabilization for efficient and affordable biocatalysts
- Enzymes and their uses
- Utility of enzymes for biocatalysis
- Enzyme stabilization problem
- Conventional enzyme-polymer conjugates
- Synthesis of enzyme-polymer conjugates via ‘Molecular Engineering’
- Synthesis of bi-enzyme-polymer conjugates
- Modification of the polymer-armor for catalysis in organic solvents
- Synthesis of multi enzyme-polymer conjugates
- Synthesis of graphene-enzyme-polymer conjugates
- Biocatalysis with NanoArmored enzymes under harsh conditions
- Advantages and disadvatages of NanoArmored Enzymes
- Conclusions and future directions of NaoArmoring of Enzymes
This chapter focuses on explaining what are enzymes, where they are found and their use in day to day life
Various pathways to different sensing platforms, the plethora of applications are discussed as background on enzymes
Discuss advantages and limitations of enzymes
Discuss the different methods used till now for enzyme stabilization and introduce the concept of ‘Entropy Minimization’
Discuss different enzyme-polymer conjugates from the literature, how they are made and their advantages and limitations
Rational synthetic routes based on ‘Entropy Minimization’
Give specific examples and protocols to make these biocatalysts and provide an assessment of their properties.
Focus on how to control the local environment around the enzyme molecules to enhance stability while maximizing activity and selectivity.
Focus on multi-reaction biocatalysts for next generation of bioreactors. That serve multiple needs in industry or academic labs.
Focus on additional stabilization and armouring conjugated enzymes using graphene or graphrene oxide without compromising the biocatalyst functions.
Unique advantages of NanoArmoring of enzymes for catalysis at extreme pHs, higher temperatures, organic solvents or other denaturing conditions
- No. of pages: 230
- Language: English
- Published: January 1, 2020
- Imprint: Elsevier
- Paperback ISBN: 9780128145357
- eBook ISBN: 9780128145364
CK
Challa Vijaya Kumar
Challa Vijaya Kumar, PhD is a senior professor at the University of Connecticut and has more than 40 years of research experience in interdisciplinary research areas including biological chemistry, physical chemistry, organic chemistry, photochemistry, biochemistry and material chemistry. He has more than 158 peer-reviewed publications and several book chapters in internationally reputed journals. He has been actively working in the area of bio-related two-dimensional materials for nearly 25 years and has published 10 papers on graphene related topics in the last 3 years. More importantly, his research lab pioneered the synthesis of graphene in aqueous conditions using proteins as exfoliating agents.
Affiliations and expertise
Departments of Chemistry and of Molecular and Cell Biology, University of Connecticut, Connecticut, USARK
Rajeswari M. Kasi
Dr. Rajeswari M. Kasi is the Polymer Program Director and Associate Professor of the Department of Chemistry, University of Connecticut, Storrs, CT, USA.
Affiliations and expertise
Department of Chemistry, University of Connecticut, Storrs, CT, USA