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Molecular Mechanisms of Transmembrane Signalling
- 1st Edition, Volume 4
- Editors: P. Cohen, M. Houslay
- Language: English
Over the past few years great strides have been made in the characterisation and purification of receptors and in elucidating the mechanisms by which extracellular s… Read more
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Over the past few years great strides have been made in the characterisation
and purification of receptors and in elucidating the mechanisms by which
extracellular signals, acting through receptors, regulate transmembrane signalling systems that control production of second messengers within the target cells. This book highlights the recent impressive advances in this area, which have led to the emergence of unifying concepts, and the linkage of areas in biology that were previously thought of as being quite separate.
and purification of receptors and in elucidating the mechanisms by which
extracellular signals, acting through receptors, regulate transmembrane signalling systems that control production of second messengers within the target cells. This book highlights the recent impressive advances in this area, which have led to the emergence of unifying concepts, and the linkage of areas in biology that were previously thought of as being quite separate.
Editors' foreword. List of contributors. Section A. Calcium in receptor signalling events. Chapter 1. Inositol phospholipid breakdown as a receptor controlled generator of second messengers (P.Downes and R.Michell). Chapter 2. The control of calcium pumps and channels and their role in regulating intracellular calcium (J.Higgins and P.England). Section B. Signal transduction through guanine nucleotide regulatory proteins. Chapter 3. Overview of the guanine nucleotide regulatory protein systems, N and N , which control adenylate cyclase activity in plasma membranes (J.K. Northup). Chapter 4. Opiate receptors in neuroblastoma x glioma hybrid cells: a system for investigating N /N interactions (W.A.Klee, G.Milligan, W.F. Simonds and B.Tocque). Chapter 5. Structural basis of adenylate cyclase stimulation and inhibition by distinct guanine nucleotide regulatory proteins (L.Birnbaumer, J.Codina, R.Mattera, R.A.Cerione, J.D.Hildebrandt, T.Sunyer, F.J.Rojas, M.G.Caron, R.J.Lefkowitz and R.Lyengar). Chapter 6. The light activated cyclic GMP phosphodiesterase system in retinal rods (B.Fung). Section C. Tyrosine specific protein kinase systems. Chapter 7. Tyrosine specific kinases as mediators of growth control (J.G.Foulkes and M.R.Rosner). Chapter 8. Epidermal growth factor receptor: characterization of its protein kinase activity (J.V.Staros, S.Cohen and M.W.Rosso). Chapter 9. The insulin receptor and signal genration at the plasma membrane (M.D.Houslay). Section D. Receptor regulation. Chapter 10. Coated pits and their role in membrane receptor internalization (C.Hopkins). Chapter 11. Molecular mechanisms of hormone receptor desensitization (D.R.Sibley, P.Nambi and R.J.Lefkowitz). Section E. Cell activation. Chapter 12. The mast cell, a paradigm for receptor and exocytotic mechanisms (B.Gomperts and C.Fewtrell). Chapter 13. Lymphocyte receptors and transmembrane signalling (E.Zanders). Chapter 14. The mitogenic response of cultured 3T3 cells: intergration of early signals and synergistic effects in a unified framework (E.Rosengurt). Section F. Bacterial chemotaxis. Chapter 15. Transmembrane signalling in bacterial chemotaxis (R.Macnab). Subject index.
- Language: English
- Edition: 1
- Volume: 4
- Published:
- Imprint: Elsevier Science