Editors' foreword. List of contributors. Section A. Calcium in receptor signalling events. Chapter 1. Inositol phospholipid breakdown as a receptor controlled generator of second messengers (P.Downes and R.Michell). Chapter 2. The control of calcium pumps and channels and their role in regulating intracellular calcium (J.Higgins and P.England). Section B. Signal transduction through guanine nucleotide regulatory proteins. Chapter 3. Overview of the guanine nucleotide regulatory protein systems, N and N , which control adenylate cyclase activity in plasma membranes (J.K. Northup). Chapter 4. Opiate receptors in neuroblastoma x glioma hybrid cells: a system for investigating N /N interactions (W.A.Klee, G.Milligan, W.F. Simonds and B.Tocque). Chapter 5. Structural basis of adenylate cyclase stimulation and inhibition by distinct guanine nucleotide regulatory proteins (L.Birnbaumer, J.Codina, R.Mattera, R.A.Cerione, J.D.Hildebrandt, T.Sunyer, F.J.Rojas, M.G.Caron, R.J.Lefkowitz and R.Lyengar). Chapter 6. The light activated cyclic GMP phosphodiesterase system in retinal rods (B.Fung). Section C. Tyrosine specific protein kinase systems. Chapter 7. Tyrosine specific kinases as mediators of growth control (J.G.Foulkes and M.R.Rosner). Chapter 8. Epidermal growth factor receptor: characterization of its protein kinase activity (J.V.Staros, S.Cohen and M.W.Rosso). Chapter 9. The insulin receptor and signal genration at the plasma membrane (M.D.Houslay). Section D. Receptor regulation. Chapter 10. Coated pits and their role in membrane receptor internalization (C.Hopkins). Chapter 11. Molecular mechanisms of hormone receptor desensitization (D.R.Sibley, P.Nambi and R.J.Lefkowitz). Section E. Cell activation. Chapter 12. The mast cell, a paradigm for receptor and exocytotic mechanisms (B.Gomperts and C.Fewtrell). Chapter 13. Lymphocyte receptors and transmembrane signalling (E.Zanders). Chapter 14. The mitogenic response of cultured 3T3 cells: intergration of early signals and synergistic effects in a unified framework (E.Rosengurt). Section F. Bacterial chemotaxis. Chapter 15. Transmembrane signalling in bacterial chemotaxis (R.Macnab). Subject index.