This book combines theoretical description of the metal–oxide interface and its fabrication with the current state of the art in characterization and applications. The book takes a holistic approach that allows the reader to approach this complex field of research from many different angles, to reach new conclusions and develop new methods and materials. Metal oxide supported metal particles are used in multiple environmental and pharmaceutical applications in the areas of materials engineering, physics, and catalysis, but their performance varies depending on the particular synthesis methods, applications, the size and kind of oxides and metal clusters, and surface properties. Metal oxides display various crystalline structures and morphologies (such as nanorods and nanosheets) each of which can result in different properties. While multiple ways of producing and characterizing metal oxide-supported nanomaterials and interfaces have been developed, depending on the application scientists often tend to use familiar methods that are traditionally applicable to their field. This book presents approaches to these materials from a diverse range of perspectives to provide a ready resource for researchers in materials science, engineering, physics, and chemistry to learn about the latest developments in the field. It elaborates how different synthesis techniques from different fields can be applied to metal oxide supported metal nanoparticles, in the belief that presenting knowledge from different perspectives can offer new insights into nanomaterials design. In addition to synthesis and characterization, recent uses of metal oxide supported metal nanoparticles are presented, including applications in the catalysis, photocatalysis, energy, and sensor fields.