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Genes and Viruses in Multiple Sclerosis
- 1st Edition
- Editors: M. Clanet, H. Wekerle, O.R. Hommes
- Language: English
The European Charcot Foundation, in its goal to support and stimulate information on new developments in Multiple Sclerosis (MS), presents an up-to-date volume on the relation of… Read more
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The European Charcot Foundation, in its goal to support and stimulate information on new developments in Multiple Sclerosis (MS), presents an up-to-date volume on the relation of genes and viruses to MS.
That genetic susceptibility might play an important role in the way the immunological system handles viral infection, or in the way brain cells react to viral invasion, has in recent years been extensively studied. Experimental evidence from animals makes a viral oligodendrocytopathy a certainty, and this in itself opens the perspective of such a disease in human beings. New insights in MS-pathology indicate that in a number of MS-patients an oligodendrocytopathy is paramount, however, proof that this may be virus-induced is absent so far.
This book discusses viral activities in the brain of Multiple Sclerosis patients, genetic backgrounds in MS and their role in brain response to viral infections, and provides evidence for viral pathogenesis of Multiple Sclerosis.
That genetic susceptibility might play an important role in the way the immunological system handles viral infection, or in the way brain cells react to viral invasion, has in recent years been extensively studied. Experimental evidence from animals makes a viral oligodendrocytopathy a certainty, and this in itself opens the perspective of such a disease in human beings. New insights in MS-pathology indicate that in a number of MS-patients an oligodendrocytopathy is paramount, however, proof that this may be virus-induced is absent so far.
This book discusses viral activities in the brain of Multiple Sclerosis patients, genetic backgrounds in MS and their role in brain response to viral infections, and provides evidence for viral pathogenesis of Multiple Sclerosis.
Introduction (O.R. Hommes).
List of Contributors.
1. Pathogenesis of MS - tracking the elusive role of B Lymphocytes (H. Wekerle, A. Iglesias, T. Litzenburger).
2. Genetic susceptibility to multiple sclerosis (A. Compston).
3. HLA controlled susceptibility to multiple sclerosis - a survey (A. Svejgaard).
4. Nordic contributions in multiple sclerosis genetics (J. Hillert).
5. Genomic screening in multiple sclerosis (F. Clerget-Darpoux).
6. Cytokine gene polymorphisms in multiple sclerosis (B.M.J. Uitdehaag).
7. Genetic control of Theiler's virus infection (M. Brahic, S. Aubagnac, L. Behrens, F. Bihl, J.-F. Bureau, S. Vigneau).
8. MHC proteins and human diseases: a tale of recognition in two immune
systems (J.L. Strominger).
9. Central nervous system delivery of therapeutic genes using viral vectors
as an alternative strategy in autoimmune demyelinating diseases (R. Furlan, P.L. Poliani, P. Marconi, E. Brambilla, F. Ruffini, A. Bergami, G. Comi, G. Martino).
10. The contribution of axonal injury to neurologic dysfunction in Theiler's virus-induced inflammatory demyelinating disease (D.R. Ure, D.B. McGavern, S. Sathornsumetee, M. Rodriguez).
11. The effect of virus-like infections on the course of multiple sclerosis (W.A. Sibley).
12. A clinical neuroradiological and virological longitudinal study to verify
the role of virus in inducing relapses in multiple sclerosis patients;
preliminary results (P. Ferrante, R. Mancuso, R. Cavarretta, E. Pagani, M. Filippi, G. Comi, G. Iannucci, P. Melzi, S. Della Bella, D. Caputo).
13. Viral and bacterial specifi cities of oligoclonal IgG bands in multiple
sclerosis (S. Gofette, C.J.M. Sindic).
14. Hepatitis B and multiple sclerosis. Hepatitis B vaccination in France (M. Clanet, D. Brassat).
15. Hepatitis B vaccination and central nervous system demyelination:
an immunological approach (E. Corcuff, J. Reboul, A. Tourbah, G. Edan, O. Gout, O. Lyon-Caen, R. Liblau).
16. Is there a causal link between hepatitis B vaccination and multiple
sclerosis? (P. Monteyne).
17. Public health aspects of hepatitis B vaccination and multiple sclerosis (Ph. Duclos, H. Hall, P. Van Damme).
18. Influenza vaccination in multiple sclerosis (J. De Keyser, G. Ramsaransing, C. Zwanikken).
19. Infection, immunization and immunomodulation - what's the difference? (P. Rieckmann, N. Moriabadi, S. Niewiesk, N. Kruse, K.V. Toyka, V. ter Meulen).
20. Detection of human herpesvirus 6 by quantitative real-time PCR in serum and cerebrospinal fluid of patients with multiple sclerosis (G. Locatelli, M.S. Malnati, D. Franciotta, R. Furlan, G. Comi, G. Martino, P. Lusso).
21. The ability of candidate viruses to explain epidemiological findings in multiple sclerosis (S. Haahr, P. Höllsberg).
22. Active human herpesvirus six viremia in patients with multiple sclerosis (K.K. Knox, J.H. Brewer, D.R. Carrigan).
23. Retroviruses in multiple sclerosis (T. Christensen, P. Dissing Sørensen, H.J. Hansen, A. Møller-Larsen).
24. The role of neuroinvasive human coronaviruses in autoimmune
processes associated with multiple sclerosis (A. Boucher, M. Tremblay, N. Arbour, J. Edwards, R. Day, J. Newcombe, P. Duquette, F. Denis, P.J. Talbot).
25. Association of multiple sclerosis with Chlamydia pneumoniae:
demonstration of the 16S rRNA gene and immunoreactivity of
CSF cationic antibodies against C. pneumoniae antigens (S. Sriram, C.W. Stratton, S. Yao, J.D. Bannan, W.M. Mitchell).
26. A rationale for antiviral therapy in multiple sclerosis (O. Andersen).
27. Antiviral activity of antiherpetic drugs in lymphoblast cells infected
with human herpes virus 6 (L. Naesens, L. De Bolle, E. De Clercq).
28. Il-1 Receptor antagonist: a possible circulating and genetic marker of interferon-beta 1b therapeutic effectiveness in MS (F.L. Sciacca, L.M.E. Grimaldi, G. Comi, N. Canal).
Subject index.
List of Contributors.
1. Pathogenesis of MS - tracking the elusive role of B Lymphocytes (H. Wekerle, A. Iglesias, T. Litzenburger).
2. Genetic susceptibility to multiple sclerosis (A. Compston).
3. HLA controlled susceptibility to multiple sclerosis - a survey (A. Svejgaard).
4. Nordic contributions in multiple sclerosis genetics (J. Hillert).
5. Genomic screening in multiple sclerosis (F. Clerget-Darpoux).
6. Cytokine gene polymorphisms in multiple sclerosis (B.M.J. Uitdehaag).
7. Genetic control of Theiler's virus infection (M. Brahic, S. Aubagnac, L. Behrens, F. Bihl, J.-F. Bureau, S. Vigneau).
8. MHC proteins and human diseases: a tale of recognition in two immune
systems (J.L. Strominger).
9. Central nervous system delivery of therapeutic genes using viral vectors
as an alternative strategy in autoimmune demyelinating diseases (R. Furlan, P.L. Poliani, P. Marconi, E. Brambilla, F. Ruffini, A. Bergami, G. Comi, G. Martino).
10. The contribution of axonal injury to neurologic dysfunction in Theiler's virus-induced inflammatory demyelinating disease (D.R. Ure, D.B. McGavern, S. Sathornsumetee, M. Rodriguez).
11. The effect of virus-like infections on the course of multiple sclerosis (W.A. Sibley).
12. A clinical neuroradiological and virological longitudinal study to verify
the role of virus in inducing relapses in multiple sclerosis patients;
preliminary results (P. Ferrante, R. Mancuso, R. Cavarretta, E. Pagani, M. Filippi, G. Comi, G. Iannucci, P. Melzi, S. Della Bella, D. Caputo).
13. Viral and bacterial specifi cities of oligoclonal IgG bands in multiple
sclerosis (S. Gofette, C.J.M. Sindic).
14. Hepatitis B and multiple sclerosis. Hepatitis B vaccination in France (M. Clanet, D. Brassat).
15. Hepatitis B vaccination and central nervous system demyelination:
an immunological approach (E. Corcuff, J. Reboul, A. Tourbah, G. Edan, O. Gout, O. Lyon-Caen, R. Liblau).
16. Is there a causal link between hepatitis B vaccination and multiple
sclerosis? (P. Monteyne).
17. Public health aspects of hepatitis B vaccination and multiple sclerosis (Ph. Duclos, H. Hall, P. Van Damme).
18. Influenza vaccination in multiple sclerosis (J. De Keyser, G. Ramsaransing, C. Zwanikken).
19. Infection, immunization and immunomodulation - what's the difference? (P. Rieckmann, N. Moriabadi, S. Niewiesk, N. Kruse, K.V. Toyka, V. ter Meulen).
20. Detection of human herpesvirus 6 by quantitative real-time PCR in serum and cerebrospinal fluid of patients with multiple sclerosis (G. Locatelli, M.S. Malnati, D. Franciotta, R. Furlan, G. Comi, G. Martino, P. Lusso).
21. The ability of candidate viruses to explain epidemiological findings in multiple sclerosis (S. Haahr, P. Höllsberg).
22. Active human herpesvirus six viremia in patients with multiple sclerosis (K.K. Knox, J.H. Brewer, D.R. Carrigan).
23. Retroviruses in multiple sclerosis (T. Christensen, P. Dissing Sørensen, H.J. Hansen, A. Møller-Larsen).
24. The role of neuroinvasive human coronaviruses in autoimmune
processes associated with multiple sclerosis (A. Boucher, M. Tremblay, N. Arbour, J. Edwards, R. Day, J. Newcombe, P. Duquette, F. Denis, P.J. Talbot).
25. Association of multiple sclerosis with Chlamydia pneumoniae:
demonstration of the 16S rRNA gene and immunoreactivity of
CSF cationic antibodies against C. pneumoniae antigens (S. Sriram, C.W. Stratton, S. Yao, J.D. Bannan, W.M. Mitchell).
26. A rationale for antiviral therapy in multiple sclerosis (O. Andersen).
27. Antiviral activity of antiherpetic drugs in lymphoblast cells infected
with human herpes virus 6 (L. Naesens, L. De Bolle, E. De Clercq).
28. Il-1 Receptor antagonist: a possible circulating and genetic marker of interferon-beta 1b therapeutic effectiveness in MS (F.L. Sciacca, L.M.E. Grimaldi, G. Comi, N. Canal).
Subject index.
- Language: English
- Edition: 1
- Published:
- Imprint: Elsevier Science
MC
M. Clanet
Affiliations and expertise
Fédération de Neurologie, CHU Toulouse Purpan, 31059 Toulouse Cedex, FranceHW
H. Wekerle
Affiliations and expertise
Max-Planck-Institut für Neurobiologie, Am Klopferspitz 18a, D-82152 Planegg-Martinsried, GermanyOH
O.R. Hommes
Affiliations and expertise
European Charcot Foundation, Heiweg 97, 6533 PA, Nijmegen, The Netherlands