“Extracellular Mitochondria in Health and Disease” offers an important tool to address the emerging research and discoveries in this field. The book provides a comprehensive and up-to-date resource for scientists/researchers and students interested in understanding the role of extracellular mitochondria in intercellular communication, disease pathology, and their potential for therapeutic applications. This book collates topics from diverse disciplines, including immunology, biochemistry, cell biology and medicine. By exploring the latest advancements in the field, “Extracellular Mitochondria in Health and Disease” bridges the existing gap in the literature and serves as an essential guide for readers of various audiences seeking to understand the roles of extracellular mitochondria and their potential for medical advancements and improved patient outcomes. This book covers topics ranging from basic research on the physiological roles and cellular mechanisms involving extracellular mitochondria, to their implication in disease pathology, to current advances in their use for therapeutic purposes. Specific topics include, among others, cellular mechanisms of mitochondrial transfer and metabolic signaling; crosstalk between extracellular vesicles and mitochondria; extracellular mitochondria in immune regulation and inflammation; extracellular mitochondria in neurodegeneration and neuroprotection; therapeutic potential of extracellular mitochondria. This book provides a comprehensive and up-to-date resource for scientists/researchers and students interested in understanding the role of extracellular mitochondria in intercellular communication, disease pathology, and their potential for therapeutic applications.