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Drug Discovery in the Microbiome
Discovery and translation of microbiome therapeutics
- 1st Edition - January 1, 2026
- Editors: Amelia Palermo, Sean M. Gibbons
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 3 0 3 6 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 3 0 3 7 - 7
Drug Discovery in the Microbiome: Discovery and translation of microbiome therapeutics provides a comprehensive outlook on novel therapeutic opportunities arising from microbiome… Read more
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Request a sales quoteDrug Discovery in the Microbiome: Discovery and translation of microbiome therapeutics provides a comprehensive outlook on novel therapeutic opportunities arising from microbiome research. This book also tackles aspects that uniquely pertain to the development and translation of therapeutics targeting the microbiome. Recent research has pointed to the microbiome as the largest untapped druggable space residing within the human body, which offers an unprecedented opportunity for the development of effective and well tolerated therapeutics. The coverage includes 30 chapters, grouped into seven main parts. Included are topics pertaining microbiome science, such as: the foundations of the human microbiome field and the lates state-of-the-art translational research approaches, intervention types, intervention personalization, and integration of the microbiome into a coherent model of inter-organ and system-scale interactions within the host. The book also covers novel bioinformatic and data modeling strategies for integrating microbiome data at the systems level, for facilitating data interpretation, for streamlining the development of precision prebiotic, probiotic, dietary, and small molecule interventions targeting the microbiome. Finally, it includes expert opinions on the reassessment of traditional drug development standards and practices in the context of the gut microbiome. Pharmacologists, pharmaceutical scientists and microbiologists will benefit from the foundations of microbiome science, and the development of therapeutics targeting the microbiome. The authors highlight the need for an end-to-end reassessment of the drug development pipeline, including preclinical and clinical trial design, drug-drug, drug-microbe, and drug-diet interaction assessments (i.e., context-dependent interactions), and regulatory standards. Clinicians involved in microbiome therapeutics will also benefit from the breadth of coverage in this book.
• Provides an overview from foundational aspects of the microbiome field, research approaches, to therapeutic applications
• Frames how the current technological and computational advances are enabling microbiome research and precision therapeutic strategies
• Tackles fundamental challenges pertaining the development and translation of microbiome therapeutics
• Covers the most promising microbiome-mediated therapeutic applications
• Frames how the current technological and computational advances are enabling microbiome research and precision therapeutic strategies
• Tackles fundamental challenges pertaining the development and translation of microbiome therapeutics
• Covers the most promising microbiome-mediated therapeutic applications
Life scientists (pharma, biochemistry, microbiology, nutrition, medicine) at Masters level and above
Part I - Introduction.
1. Overview of the Human Microbiome Field
2. Significance of the Microbiome in Health and Disease
3. Scope of the Book
Part II - Fundamentals of Microbiome Research
4. Composition and Function
5. Techniques and Tools for Microbiome Research
6. Microbiome Dysbiosis and Disease
Part III - Therapeutic Potential of the Gut Microbiome
7. Targeting the Gut Microbiome for Drug Discovery
8. Role of Diet, Probiotics, Prebiotics, and Postbiotics
9. Fecal Microbiota Transplantation (FMT) and ‘Bugs-as-drugs’ Therapies
10. Gut Microbiome and Personalized Medicine
Part IV - Precision Interventions including AI-Augmented Strategies
11. Computational Tools for Gut Microbiome Intervention
12. Mining Microbiome Community Dynamics in silico
13. Databases for Microbiome Research
14. Machine Learning and Mechanistic Modeling in Gut Microbiome Analysis and Prediction
15. Utility of AI for Gut Microbiome Research
16. AI-Augmented Microbiome Drug Discovery and Development Part V - Case Studies in Gut Microbiome Therapeutics
17. Gut Microbiome-Based Therapies for Gastrointestinal Disorders
18. Gut Microbiome Modulation in Metabolic Disorders
19. Gut Microbiome Modulation in Cancer
20. Gut Microbiome and Immune System-Related Therapies
21. Gut Microbiome and Mental Health/the Gut-Brain Axis
Part VI - Regulatory and Funding Considerations for Effective Translation
22. Regulatory Landscape for Gut Microbiome Therapeutics
23. Preclinical and Clinical Study Design for Microbiome Therapeutics
24. Considerations on Intellectual Property and Commercialization
25. Funding Considerations for Microbiome Research/Translation
Part VII - Outlook and Emerging Trends
26. Integration of Microbiome Therapeutics into Mainstream Healthcare
27. Ethical Considerations and Responsible Use of Microbiome Therapies
28. Potential Impact of Gut Microbiome Research on Public Health
29. Conclusion
30. Summary of Key Points and Future Implications
Appendix A: Glossary of Terms
Appendix B: Resources for Further Reading
Acknowledgments
Index
1. Overview of the Human Microbiome Field
2. Significance of the Microbiome in Health and Disease
3. Scope of the Book
Part II - Fundamentals of Microbiome Research
4. Composition and Function
5. Techniques and Tools for Microbiome Research
6. Microbiome Dysbiosis and Disease
Part III - Therapeutic Potential of the Gut Microbiome
7. Targeting the Gut Microbiome for Drug Discovery
8. Role of Diet, Probiotics, Prebiotics, and Postbiotics
9. Fecal Microbiota Transplantation (FMT) and ‘Bugs-as-drugs’ Therapies
10. Gut Microbiome and Personalized Medicine
Part IV - Precision Interventions including AI-Augmented Strategies
11. Computational Tools for Gut Microbiome Intervention
12. Mining Microbiome Community Dynamics in silico
13. Databases for Microbiome Research
14. Machine Learning and Mechanistic Modeling in Gut Microbiome Analysis and Prediction
15. Utility of AI for Gut Microbiome Research
16. AI-Augmented Microbiome Drug Discovery and Development Part V - Case Studies in Gut Microbiome Therapeutics
17. Gut Microbiome-Based Therapies for Gastrointestinal Disorders
18. Gut Microbiome Modulation in Metabolic Disorders
19. Gut Microbiome Modulation in Cancer
20. Gut Microbiome and Immune System-Related Therapies
21. Gut Microbiome and Mental Health/the Gut-Brain Axis
Part VI - Regulatory and Funding Considerations for Effective Translation
22. Regulatory Landscape for Gut Microbiome Therapeutics
23. Preclinical and Clinical Study Design for Microbiome Therapeutics
24. Considerations on Intellectual Property and Commercialization
25. Funding Considerations for Microbiome Research/Translation
Part VII - Outlook and Emerging Trends
26. Integration of Microbiome Therapeutics into Mainstream Healthcare
27. Ethical Considerations and Responsible Use of Microbiome Therapies
28. Potential Impact of Gut Microbiome Research on Public Health
29. Conclusion
30. Summary of Key Points and Future Implications
Appendix A: Glossary of Terms
Appendix B: Resources for Further Reading
Acknowledgments
Index
- No. of pages: 700
- Language: English
- Edition: 1
- Published: January 1, 2026
- Imprint: Academic Press
- Paperback ISBN: 9780443330360
- eBook ISBN: 9780443330377
AP
Amelia Palermo
Dr. Palermo investigates metabolism in health and disease by high-throughput omics such as metabolomics, transcriptomics, and systems biology. Her areas of focus include the discovery of active molecules and druggable metabolic vulnerabilities in the context of cancer, immunity, and the microbiome. Her interests also encompass the development of novel platforms for processing samples at high-throughput and with single cell resolution, and of improved tools for multi-omics "big data" integration and interpretation for precision approaches.
Affiliations and expertise
UCLASG
Sean M. Gibbons
Dr. Gibbons directs microbiome and precision medicine research efforts at the Institute for Systems Biology (ISB). His lab develops computational and wet-lab tools for exploring and engineering host-microbe systems. Specifically, he is interested in understanding the ecological and evolutionary rules underlying the behavior of commensal microbiota well enough to build mechanistic or statistical models that enable personalized engineering of the functional outputs of the system to prevent or treat complex human diseases.
Affiliations and expertise
Institute for Systems Biology