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Biophysics of tissue self-organization in morphogenesis
The role of dynamics along the biointerface
- 1st Edition - July 1, 2025
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 0 0 4 8 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 0 0 4 9 - 3
“Biophysics of tissue self-organization in morphogenesis: The role of dynamics along the biointerface” examines interactions between tissue and the extracellular matrix. This… Read more
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Request a sales quote“Biophysics of tissue self-organization in morphogenesis: The role of dynamics along the biointerface” examines interactions between tissue and the extracellular matrix. This interdisciplinary book covers the fundamentals of cell self-rearrangement and the inter-relation between these biological mechanisms and physical mechanisms responsible for tissue self-organisation. It provides an introduction to tissue self-organisation in morphogenesis before exploring its physics from subcellular to supracellular levels. Modeling approaches to tissue self-organization are explored, followed by discussion of the application of engineering principles to solve biological and medical problems related to the tissue self-organisation. A range of tools, applications, and medical implications are also covered, including embryo development, wound healing, and cancerous diseases. The book closes with a look to future developments in the field. “Biophysics of tissue self-organization in morphogenesis" provides a detailed introduction to this topic, and is a valuable resource for researchers across the areas of cell biology, cell physiology, biophysics, developmental biology, tissue biomechanics, and pathophysiology.
• Describes biological mechanisms of cell self-rearrangement from subcellular to
supracellular levels
• Explores mathematical modelling approaches of tissue self-organization
• Considers engineering principles to solve biological and medical problems related to
tissue self-organisation
• Discusses tissue self-organisation within various in vivo and in vitro organoid systems
supracellular levels
• Explores mathematical modelling approaches of tissue self-organization
• Considers engineering principles to solve biological and medical problems related to
tissue self-organisation
• Discusses tissue self-organisation within various in vivo and in vitro organoid systems
Researchers in cell biology, cell physiology, biophysics, developmental biology, tissue biomechanics, and pathophysiology
Section 1: Tissues self-organisation in morphogenesis
1. Cell adhesion: Common mechanisms and physical principles
2. Analysis of the effect of cell movement on gene expression dynamics in development
3. Force transmission across scales: Examples and measuring methods
4. The impact of air pollution on the tissue self-organisation within co[1]cultured lung systems
Section 2: Physics of tissue self-organisation from subcellular to supracellular levels
5. How physical cues guide cell collectives, from local adhesion to global
force transmission
6. Cellular death and division events at tissue interfaces: A chicken-or[1]the-egg situation
7. Active Nematics: Exploring the Interplay between structure and
dynamics in cell cultures
8. The dynamics along the epithelial-cancer biointerface within co[1]cultured cell spheroids: Physical aspects
9. Dynamical interplay at the interfaces of cancer cells, immune cells and stromal cells in the extracellular space of artificial model systems
and tissues
10. Techniques development to quantify cell-scale dynamic mechanical
interactions in extracellular matrices of tissues
Section 3: Modeling of the tissue self[1]organization
11. Mathematical modelling approaches to collective cell movement: Leader
vs. follower cells
Section 4: Engineering of human tissues
12. Engineering of humantissues
13. Conclusion and outlook
1. Cell adhesion: Common mechanisms and physical principles
2. Analysis of the effect of cell movement on gene expression dynamics in development
3. Force transmission across scales: Examples and measuring methods
4. The impact of air pollution on the tissue self-organisation within co[1]cultured lung systems
Section 2: Physics of tissue self-organisation from subcellular to supracellular levels
5. How physical cues guide cell collectives, from local adhesion to global
force transmission
6. Cellular death and division events at tissue interfaces: A chicken-or[1]the-egg situation
7. Active Nematics: Exploring the Interplay between structure and
dynamics in cell cultures
8. The dynamics along the epithelial-cancer biointerface within co[1]cultured cell spheroids: Physical aspects
9. Dynamical interplay at the interfaces of cancer cells, immune cells and stromal cells in the extracellular space of artificial model systems
and tissues
10. Techniques development to quantify cell-scale dynamic mechanical
interactions in extracellular matrices of tissues
Section 3: Modeling of the tissue self[1]organization
11. Mathematical modelling approaches to collective cell movement: Leader
vs. follower cells
Section 4: Engineering of human tissues
12. Engineering of humantissues
13. Conclusion and outlook
- No. of pages: 400
- Language: English
- Edition: 1
- Published: July 1, 2025
- Imprint: Academic Press
- Paperback ISBN: 9780443300486
- eBook ISBN: 9780443300493