Fundamentals and Future Trends of 3D Printing in Drug Delivery

1st Edition - November 20, 2024
Editors: Dimitrios A. Lamprou, Dimitrios G. Fatouros
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 2 3 6 4 5 - 7
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 3 6 4 6 - 4

Fundamentals and Future Trends of 3D Printing in Drug Delivery provides readers with all needed information for their journey from ideation to approval of innovative drug delivery… Read more

Purchase options

Institutional subscription on ScienceDirect

Request a sales quote

Fundamentals and Future Trends of 3D Printing in Drug Delivery provides readers with all needed information for their journey from ideation to approval of innovative drug delivery devices produced through additive manufacturing.

This book provides an in-depth discussion on key factors affecting the printing process such as different printer technologies, materials selection, resolutions, temperatures and speeds. Dedicated chapters include specific drug delivery devices in the form of oral solid dosage, implants, catheters and vascular grafts, and microneedles. The prospects of 3D printing associated with personalized medicine are covered in a full chapter.

Fundamentals and Future Trends of 3D Printing in Drug Delivery is the perfect reference for any researcher or professional embarking on a 3D printing process for drug delivery devices. The regulatory aspects included are of particular interest to companies entering this promising market.

Title of Book
Cover image
Title page
Table of Contents
Copyright
Contributors
Preface
Chapter 1. Overview of emerging printing technologies: How 2D printing has evolved towards multidimensional printing
Introduction
Applications of two-dimensional (2D) printing in drug delivery
2D materials
2D printing advancements in drug delivery
Applications of three-dimensional printing in drug delivery
Introduction to three-dimensional printing
Types of 3D-printed drug delivery systems
3D printed solid oral dosage forms
3D printed transdermal drug delivery systems
3D printed medical device drug delivery systems
3D printed drug eluting implants
4D printing technology
Mechanism of smart materials
Categories of external stimuli
Temperature
Liquid absorption
Light
Magnetic field
Electric field
pH
4DP hydrogels
4DP microneedles
4DP drug-eluting implants
5D printing technology
6D printing technological performance
Future manufacturing marvels: The perception of 7D printing process
Conclusions
MCQs
Chapter 2. 3D-printing technologies for pharmaceutical applications
Introduction
3D-printing technologies for drug delivery
Extrusion based 3D-printing technologies
Fused Deposition Modeling (FDM)
Semisolid Extrusion (SSE)
Direct Powder Extrusion
Micro-extrusion
Vat Polymerization
Stereolithography (SLA)
Two-photon polymerization (2PP)
Digital Light Processing (DLP)
Continuous Liquid Interface Production (CLIP)
Powder Bed Fusion (PBF)
Selective Laser Sintering (SLS)
Inkjet Printing
Material Jetting (MJ)
Binder Jetting (BJ)
Conclusions
MCQs
Chapter 3. Polymeric biomaterials for 3D printing
Introduction
3D printing techniques
Selective laser sintering (SLS)
Stereolithography (SLA)
Inkjet
Polyjet
Fused filament fabrication (FFF)
Bioprinting
Synthetic polymers
Polycaprolactone (PCL)
Polylactic acid (PLA)
Polycarbonate (PC)
Polyetheretherketone (PEEK)
Polyethylene glycol (PEG)
Thermoplastic polyurethane (TPU)
Polypropylene (PP)
Polyamides
Acrylonitrile butadiene styrene (ABS)
Polydimethylsiloxane (PDMS)
Polymer composites
Bio-based polymers
Gelatin
Collagen
Chitosan
Cellulose
Biocomposites
Engineered living materials: Next generation of bioinks
Conclusions
Chapter 4. Design optimization and finite element analysis of 3D printed drug delivery systems
Introduction
Design optimization in 3D printed drug delivery systems
Introduction to design principles
Considerations for designing drug delivery systems
Geometry
Material selection
Drug release mechanisms
Dosage control
Importance of optimization
Enhancing drug delivery efficiency
Precise dosage control
Reduction of side effects
Improving patient adherence
Finite element analysis (FEA) in 3D printed drug delivery systems
Introduction to FEA
Benefits of FEA
Stress analysis
Deformation analysis
Fluid dynamics and drug dispersion
Thermal analysis
Case studies
A novel 3D printing approach for creating drug-filled capsules: A case study
Fabrication and finite element analysis of stereolithographic 3D printed microneedles for transdermal drug delivery: A case study
Conclusion
Chapter 5. 3D printing in personalized medicine
Taking advantage of 3D printed personalized medicines
Tailored dosage and release profiles
Enhanced patient compliance
Reduced healthcare costs
Major challenges overcome by 3D printing techniques compared to conventional technologies
Implementation of 3D printed personalized medicines in clinical practice
Safety and quality assessment of 3D printed medicines for implementation into clinical practice
Healthcare professionals and patient acceptability of 3D printed personalized medicines
Physicians' acceptability
Pharmacists' acceptability
Patient's acceptability
Challenges and barriers to 3D printed medicine implementation
Regulatory issues
Technological limitations
Cost and accessibility
Unlocking the potential of 3D printed personalized medicines in clinical practice
Integration with other technologies
Expanding the range of printable materials and drug combinations
Developing new business models
Education and training of healthcare professionals
Future perspectives and conclusions
Chapter 6. 3D printed bespoke solid dosage forms for oral drug delivery
Solid oral dosage forms (SODFs)
3D-printing basics
Advantages of 3D-Printing
3D-printing in pharmaceutics: Characteristics of 3D-Printed SODFs
3D-printing methods in SODFs manufacturing
Vat polymerization
Extrusion based technic
Powder based technic
Inkjet based technic
SODF 3D-Printing materials
Examples of 3D-Printed SODFs
Tablets
Gastro-retentive tablets
Immediate release tablets
Modified release tablets
Orodispersible tablets (ODTs)
Polypills
Capsules
Oral films
Sweet-like SODFs
Future of SODF 3D-Printing
Conclusion
Chapter 7. Development of 3D printed drug-loaded catheters and vascular grafts
Introduction
What are vascular grafts?
Physiology of blood vessels
Design requirement of vascular grafts
What are catheters?
Drugs used in catheters and vascular grafts
General overview of 3D printing techniques
Different mechanisms for drug loading
Fabrication of 3D printed vascular grafts
Fabrication of 3D printed catheter
Future directions and conclusions
Multiple choice questions
Chapter 8. 3D printed microneedle patches for painless drug delivery
Introduction
Microneedle (MN) system
Classification and characteristics of microneedles
Solid microneedles
Coated microneedles
Hollow microneedles
Dissolving microneedles
Hydrogel microneedles
Porous microneedles
Materials used in the production of microneedles
Manufacturing of MNs
Lithography
Laser ablation
Moulding
3D-printing techniques applied in microneedle manufacturing
Stereolithography (SLA)
Digital light processing (DLP)
Fused deposition modeling (FDM)
Continuous liquid interface production (CLIP)
Two-photon polymerization (TPP)
Potential applications of 3DP MNs as drug delivery systems
Diabetes and glucose control
Skin tumours
Contraceptives
Bacterial infections
Vaccination
Wrinkles
Combining 3DP with other techniques to obtain MNs for drug delivery
Summary
MCQ
Answers
Chapter 9. 3D printed therapeutic scaffolds for wound healing applications
Introduction
Cells in 3D printing technology
Fibroblasts cells
Epithelial cells
Immune cells
Wounds and inflammation
The immune response to the inserted material
Immunomodulation—3D immunomodulatory microenvironment
Conclusions
Chapter 10. 3D-printed implants targeting gynaecological disease
Introduction
Biological and clinical background
The vaginal microbiome
Gynaecological diseases
Antiviral and antibiotic treatment for gynaecological diseases
3D-printing for gynaecological applications
Types of 3D-printing
Intra-vaginal drug delivery via 3D-printed implants
Engineering considerations
3D-printing design parameters
Biomaterials in gynaecological applications and their incorporation with 3D-printing
Mechanical properties of 3D-printed implants
3D-printed implants to deliver alternative treatments
Summary
Chapter 11. 3D printing in preclinical evaluation
Introduction
Characterization of feedstock materials and 3D-printed drug products
Physical appearance, mass, and content uniformity
Disintegration and dissolution
Mechanical properties
Solid-state properties
Physical, chemical, and microbiological stability
Non-destructive quality control
Concluding remarks
Chapter 12. 4D printed therapeutic systems
Introduction
Progression from 3D to 4D: Evolution of bioprinting
Shape memory polymers
Stimuli-responsive hydrogels
Thermo-responsive hydrogels
Photo-responsive hydrogels
pH-responsive hydrogels
Swelling-based shape transformation of hydrogels
Magneto-responsive hydrogels
Applications of 4D bioprinted therapeutic systems
4D printing for tissue engineering
4D printed drug delivery systems
Conclusion
Chapter 13. Additive Manufacturing (AM) and AI
Introduction
Goal and direction of this chapter
Content overview
3D printing classifications
3D printing and AM enabling technologies
Inkjet 3D printing
Powder deposition
Spray drying
Bio printing
4D, 5D, 6D printing
Industry 5.0 and mass customization
Integration of processes
Production lifecycle—AI-related processes
Logistics processes in general and logistics trends
Process logistics and lean techniques
Logistic trends, AI and AM
Resources problem and AI and AM
AM in the context of resources
AI in the context of resources
The knowledge context as a resource problem
Future research program: System dynamics integration as a future trend and epistemology of science
Summary and outlook
Chapter 14. Regulatory aspects of 3D printing systems in healthcare
Introduction
3D-printed products
Medicinal products
Medical devices
3D-printing in healthcare settings
3D printing at point-of-care
3D printing integrated with medical device software
Summary
Index

Dimitrios A. Lamprou

Dr. Lamprou is Full Professor, Chair of Biofabrication and Advanced Manufacturing, and Director at MSc Industrial Pharmaceutics at Queen's University Belfast. He is also the Chair at United Kingdom and Ireland Controlled Release Society (UKICRS) and the Chair of the Academy of Pharmaceutical Sciences (APS) Emerging Technologies Focus Group. Dimitrios, is the author of over 140 peer-reviewed publications (including 3 books in 3D Printing area), has over 350 conference abstracts, has given over 150 Invited Talks in institutions and conferences across the world, and has secure Funding more than £3M. Dimitrios, has been recognized as world leader in 3D Printing with PubMed-based algorithms placed him in the top 0.088% of scholars in the world writing about 3D Printing in the last 10 years. Dimitrios has also been named in the Stanford University's list 2021 & 2022 of World's Top 2% Scientists, for his research in Pharmaceutics and Biomedical Engineering.

Affiliations and expertise

Professor, School of Pharmacy, Material and Advanced Technologies for Healthcare, Queen’s University Belfast, Northern Ireland, UK

Dimitrios G. Fatouros

Dimitris Fatouros is Professor in Pharmaceutics at Aristotle University of Thessaloniki School of Pharmacy. He holds a PhD in Pharmaceutical Technology from the School of Pharmacy at the University of Patras in Greece. He subsequently held posts as a Post-Doctoral fellow at Leiden/Amsterdam Centre of Drug Delivery (LA/CDR), Research Assistant Professor at Danish University of Pharmaceutical Sciences and Senior Lecturer at School of Pharmacy and Biomedical Portsmouth University. His areas of research expertise cover additive manufacturing, mucosal delivery, nanomedicine and poorly soluble drugs. He has contributed over 180 publications in refereed journals and books. He has filled three national (granted) and five international patents. He has been Theme Editor in Advanced Drug Delivery Reviews “Personalized nanomedicine” (Editors, Vizirianakis and Fatouros, ADDR 2012 64 :1359-62) and “Additive Manufacturing in Pharmaceutical Product Design” (Editors, Rantanen and Fatouros 2021 178:113991). He is Associate Editor in Journal of Drug Delivery Science and Technology (Elsevier), Associate Editor in Frontiers and Bioengineering and Biotechnology and member of the Editorial Board of Pharmaceutics.

Affiliations and expertise

Professor, Department of Pharmacy, Aristotle University of Thessaloniki, Greece

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Fundamentals and Future Trends of 3D Printing in Drug Delivery

Purchase options

Institutional subscription on ScienceDirect

Dimitrios A. Lamprou

Dimitrios G. Fatouros