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Elsevier

Books in Organic chemistry

This collection offers extensive coverage of organic synthesis, reaction mechanisms, and functional group chemistry. Showcasing innovative research, green chemistry approaches, and industrial applications, it supports chemists, students, and researchers in designing new molecules and materials. Addressing drug discovery, polymers, and sustainable processes, these titles foster creativity and technical excellence in advancing organic chemistry for societal benefit.

  • Synthetic Strategies in Carbohydrate Chemistry

    • 1st Edition
    • Vinod Kumar Tiwari
    • English
    Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotect... strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry.

  • Synthesis of Metal-Organic Frameworks via Water-Based Routes

    A Green and Sustainable Approach
    • 1st Edition
    • Yasser Azim + 3 more
    • English
    Synthesis of Metal-Organic Frameworks via Water-Based Routes: A Green and Sustainable Approach describes a sustainable approach for the synthesis of metal-organic frameworks. Bringing together chapters on the aqueous synthesis and stability of metal-organic frameworks, as well as the applications of water stable metal-organic frameworks, this timely book shows how green processing technology utilizing water as a main solvent for the synthesis of metal-organic frameworks can eliminate solvent consumption, lower investment costs and reduce energy requirements. Providing quantitative descriptions and reliable guidelines, the book summarizes the fundamental approaches and principles to prepare metal-organic frame works, highlighting the most exciting preparations and applications.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 79
    • Atta-Ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it's possible to isolate and rapidly determine the structures and biological activity of natural products.

  • Renewable Dyes and Pigments

    • 1st Edition
    • Shahid Ul Islam
    • English
    Renewable Dyes and Pigments takes an interdisciplinary approach to bridging the gap between established knowledge of traditional natural dyes and pigments and their emerging aspects in various rapidly growing industrial sectors. Research into new natural dye and pigment sources along with the discovery of sophisticated instrumentation and technology for their processing, characterization, and applications has greatly assisted in widening their scope in various advanced application disciplines is covered, along with information on a number of synthetic dyes and their detrimental effects on the environment and associated allergic, toxic, carcinogenic, and harmful responses. Amidst growing environmental and health concerns, eco-friendly, non-toxic dyes and pigments from renewable materials have re-emerged as a potential viable, sustainable option as an alternative or co-partner to synthetic compounds. This book covers a wide range of topics related to the chemistry and applications of natural dyes and pigments, with an emphasis on recent technological developments in textile dyeing, the food sector and the use of natural pigments in dye-sensitized solar cells, and more.

  • The Alkaloids

    • 1st Edition
    • Volume 90
    • English
    The Alkaloids, Volume 90, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on Recent Progress in the Chemistry of Naphthylisoquinoline Alkaloids, The Biological Activities of Quinolizidine Alkaloids, and C NMR Spectral Data and Pharmacological Activities of Aporphine Alkaloids.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 78
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 78 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.

  • Dihydropyrimidinones as Potent Anticancer Agents

    Medicinal Chemistry Perspective
    • 1st Edition
    • Mashooq Ahmad Bhat + 2 more
    • English
    Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge, accomplishments and recent advances in the medicinal chemistry of dihydropyrimidinones in cancer treatment. Dihydropyrimidinones are known to be active scaffold and have been reported to show some exceptional results with regards to malignancies. With ever increasing knowledge and information about synthesis, pharmacology and other aspects of dihydropyrimidinones... there is need to document such information in one place. Since the field of medicinal chemistry is dynamic, with new emerging trends, it provides readily available updated information on chemistry and pharmacology aspects of dihydropyrimidinones in cancer. This book covers everything about dihydropyrimidinones from synthesis, derivatives, mode of action and potential therapeutic targets. It will also provide insights about the clinical trials and way forward in cancer research of dihydropyrimidinones...

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 141
    • English
    Advances in Heterocyclic Chemistry, Volume 141, latest release in this definitive series, combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Chapters in this new release include Recent Advances in the Synthesis of 5-Membered Heterocycles via Domino and Multicomponent Reactions (from 2017-2022), Recent Advances in Application of the Stetter Reaction in Heterocyclic Chemistry, Recent Developments in the Hantzsch Synthesis of Dihydropyridines, Recent Developments in the Chemistry of 1H- and 4H-1,2,4-Triazoles, and much more.

  • Nanotechnology and In Silico Tools

    Natural Remedies and Drug Discovery
    • 1st Edition
    • Mital Kaneria + 1 more
    • English
    Nanotechnology and In Silico Tools: Natural Remedies and Drug Discovery provides the latest information and updates in the area of drug discovery. The book covers aspects like nanomedicines, bioinformatics, molecular docking, molecular modeling, QSAR, virtual screening, and computational chemistry as well as metabolomics research using various tools. It combines the principles of natural medicines with refined modern technology to help chemists in the development of a more ecofriendly and effective discovery process.The drug discovery process accelerates the design of new leads for various life-threatening diseases and natural medicines. Silico tools have been an integral part of the drug discovery process, playing a major role as a template for drug discovery and offering a holistic approach to better management of various diseases.

  • Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis

    • 1st Edition
    • Junliang Zhang + 1 more
    • English
    Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis summarizes the most significant progress in the field of chiral phosphine ligand chemistry and a broad range of earth-abundant transition metal/chiral phosphine ligand-catalyzed enantioselective transformations. The book provides an authoritative and in-depth understanding of important topics about asymmetric catalysis based on earth-abundant transition metals/chiral phosphine ligands, making it ideal for organic chemistry researchers working in the field of asymmetric catalysis, synthetic methodologies and total synthesis.The development of new chiral phosphine ligands to achieve precise stereo control in many earth-abundant transition metal-catalyzed reactions is a very important field in organic synthesis, materials science and medicinal chemistry. The asymmetric synthesis promoted by transition metal/chiral phosphine ligands provides one of the most ideal ways to produce valuable optically active chemicals.

  • Handbook of Biomolecules

    Fundamentals, Properties and Applications
    • 1st Edition
    • Chandrabhan Verma + 1 more
    • English
    Handbook of Biomolecules: Fundamentals, Properties and Applications is a comprehensive resource covering new developments in biomolecules and biomaterials and their industrial applications in the fields of bioengineering, biomedical engineering, biotechnology, biochemistry, and their detection methods using biosensors. This book covers the fundamentals of biomolecules, their roll in living organism, structure, sources, important characteristics, and the industrial applications of these biomaterials. Sections explore amino acids, carbohydrates, nucleic acids, proteins, lipids, metabolites and natural products, then go on to discuss purification techniques and detection methods. Applications in biomolecular engineering, biochemistry and biomedical engineering, among others, are discussed before concluding with coverage of biomolecules as anticorrosion materials.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 77
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 77 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. This book covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Studies in Natural Product Chemistry

    • 1st Edition
    • Volume 76
    • Atta-ur Rahman
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Medicinal Chemistry of Anticancer Drugs

    • 3rd Edition
    • Carmen Avendaño + 1 more
    • English
    This third edition of Medicinal Chemistry of Anticancer Drugs, provides an updated resource for students and researchers from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. This new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theranostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point of view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references to reviews and the primary literature.

  • Oxetane Synthesis

    • 1st Edition
    • Navjeet Kaur
    • English
    Oxetane Synthesis rings play an important role as versatile motifs both in the overall formation of natural products and in synthetic organic chemistry. Oxetanes are important motifs in pharmaceutical chemistry that can confer improved metabolic and physicochemical properties. These developments continue to enhance the use of oxetanes in medicinal chemistry. Thanks to the growing commercial accessibility of oxetane possessing building blocks, together with improved approaches for the formation, oxetanes are likely to be progressively utilized in medicinal chemistry programs. Oxetanes are becoming valuable as a result of their vast diversity of uses in medicinal chemistry and varying applications. Several procedures have been developed for the formation and ring-opening of oxetanes to give important compounds in agrochemical, medicinal and material sciences. Novel approaches have been developed for the synthesis of oxetanes. These methods depend on both established synthetic approaches and development of many novel approaches for the formation of oxetanes.

  • Nanoparticles in Green Organic Synthesis

    Strategy towards Sustainability
    • 1st Edition
    • Sabyasachi Bhunia + 4 more
    • English
    Nanoparticles in Green Organic Synthesis: Strategy towards Sustainability presents the fundamental and latest practical uses of metal nanoparticles (MNPs) in organic synthesis, as well as their promising multidimensional applications. The book examines the latest emerging research on MNP synthesis and their applications—from organic transformation to energy and the environment—allowing readers to critically analyze the role of different MNPs in seeking ideas for widespread application. The book covers the fundamentals while also providing a comprehensive account of MNPs and their modification for a variety of green platform-based derivatives, focusing on the multifunctional technological evolution. The book covers a wide range of applications in organic synthesis using a variety of transition-metal-bas... nanoparticles in both homo- and heterogeneous media. The text details the concept of catalyst design and recent developments in the preparation and characterization of nanomaterials, followed by several chapters on the design of catalysts for specific applications. This volume is a valuable resource for those working in green chemistry, sustainability, material science and engineering, nanotechnology, energy, and the environment.

  • Marine Phenolic Compounds

    Science and Engineering
    • 1st Edition
    • Jose Ricardo Perez Correa + 2 more
    • English
    Marine Phenolic Compounds: Science and Engineering is a comprehensive resource on these secondary metabolites. Phenolic compounds are secondary metabolites with increasing scientific, commercial and general population interest for their wide distribution, variety and potential applications Less studied than terrestrial sources, marine organisms contain highly interesting phenolic compounds due to their exclusive structures. In addition, the distinctive features of the marine solid matrix, requires novel process technology approaches. The high productivity of marine biomass makes it a renewable source of valuable components with potential for commercial applications.

  • Iodine-Assisted Synthesis of Six- and Seven-Membered Heterocycles

    • 1st Edition
    • Navjeet Kaur
    • English
    Iodine-Assisted Synthesis of Six- and Seven-Membered Heterocycles covers both existing and the latest methods for the synthesis of various six- and seven-membered heterocycles using iodine. Covering an important and rapidly growing branch of heterocyclic chemistry, this book allows users easy access to the synthetic protocols for the synthesis of heterocycles, acting as a guide for how to make these important compounds employed as agrochemicals, pharmaceuticals, and veterinary products, using particular reagents. This book will be of interest to students, pharmacologists, biochemists, and organic and medicinal chemists.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 139
    • Eric F.V. Scriven + 1 more
    • English
    Advances in Heterocyclic Chemistry, Volume 139, the latest release in this definitive series on the field of heterocyclic chemistry, combines descriptive synthetic chemistry and mechanistic insights to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Topics in this new release include Application of the Fischer indole synthesis in medicinal chemistry, Oxindole Synthesis via C-H Activation Methods, Ring-Closing Metathesis in the Synthesis of Fused Indole Structures, Synthesis of fuller heterocycles, The Literature of Heterocyclic Chemistry, Part XX, 2020, and Heterocyclic Zwitterions Based on Coupled Polymethines.

  • 5-Membered Heterocycle Synthesis Using Iodine

    • 1st Edition
    • Navjeet Kaur
    • English
    5-Membered Heterocycle Synthesis Using Iodine presents both old and new methods for the synthesis of various five-membered heterocycles using iodine, providing information for making specific compounds using particular reagents. Heterocyclic frameworks represent the main structural subunits of many biologically active compounds and natural products, and the ability of heterocycles to act both as reactive pharmacophores and biomimetics has greatly contributed to their unique value as traditional key elements of various drugs. Contemporary developments in process chemistry and discovery emphasize novel sustainable synthetic pathways as fast and ecologically acceptable alternatives to the traditional protocols. This book serves as a guide for students, pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals to obtain easy access to synthetic protocols for different five-membered heterocycles using iodine.

  • Synthesis of Azetidines from Imines by Cycloaddition Reactions

    • 1st Edition
    • Navjeet Kaur
    • English
    Synthesis of Azetidines from Imines by Cycloaddition Reactions presents several methodologies for the synthesis of azetidines from imines by cycloaddition reactions. The azetidines, known as important contribution of science to humanity, are important organic compounds that have occupied a basic position in the pharmaceutical chemistry for over a hundred years because of their biological activities. They are the fundamental skeleton of several antibiotics, probiotics and alkaloids. The synthesis of azetidines is a constant challenge for medicinal chemists, hence this book comprehensively describes azetidine ring synthesis. With this book, readers will be able to quickly assess possible synthetic approaches and evaluate whether preparation of a four-membered nitrogen containing ring is reasonable.

  • Progress in Heterocyclic Chemistry

    Volume 34
    • 1st Edition
    • Volume 34
    • Gordon Gribble + 1 more
    • English
    Progress in Heterocyclic Chemistry: Volume 34, the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC), contains both highlights of the previous year’s literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. Highlight chapters in Volume 34 are all written by leading researchers in their field, thus constituting a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2021. As with previous volumes in the series, Volume 34 will enable academic and industrial chemists and advanced students to keep abreast of developments in heterocyclic chemistry in a convenient way.

  • Anti-Aging Pharmacology

    • 1st Edition
    • Vitaly Koltover
    • English
    **Association of American Publishers (AAP) PROSE Award Finalist in Clinical Medicine, 2024**Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm.This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.

  • Special Volume in Memory of Hidetoshi Yamada Part 2

    • 1st Edition
    • Volume 82
    • David C. Baker
    • English
    Special Volume in Memory of Hidetoshi Yamada, Part Two, Volume 82 in the Advances in Carbohydrate Chemistry and Biochemistry series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Updates in this new release include Automated and/or Electrochemical Synthesis, In Vivo Chemistry, Pseudo-Glycoconjugat... with C-Glycoside linkage, Boron-Mediated Aglycon Delivery (BMAD) for the Stereoselective Synthesis of 1,2-cis Glycosides, and Conformationally Restricted Donors for Stereoselective Glycosylation.

  • Phytochemistry, Computational Tools, and Databases in Drug Discovery

    • 1st Edition
    • Chukwuebuka Egbuna + 2 more
    • English
    Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the discovery of new drugs against specific diseases are presented, along with computational tools for the prediction of the toxic effects of phytochemicals on living systems. The book also provides in-depth insight on the applications of these computational tools as well as the databases that describe the interactions of phytochemicals with diseases along with predictions for druggable bioactive compounds. Useful for drug developers, medicinal chemists, toxicologists, phytochemists, plant biochemists and analytical chemists, this book clearly presents the various computational techniques, tools and databases for phytochemical research.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 56
    • English
    Advances in Physical Organic Chemistry, Volume 56 presents the latest reviews of recent work in physical organic chemistry. The book provides a valuable source of information that is ideal not only for physical organic chemists applying their expertise to both novel and traditional problems, but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Chapters due to be included in this release cover flavin-dependent enzyme catalysed reactions, coacervates and their properties, heavy atom tunnelling, machine learning, acidity and substituent effects.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 111
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 111, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists.

  • Special Volume in Memory of Hidetoshi Yamada Part 1

    • 1st Edition
    • Volume 81
    • English
    Special Volume in Memory of Hidetoshi Yamada, Volume 81, Part One, the latest release in the Advances in Carbohydrate Chemistry and Biochemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Automated and/or Electrochemical Synthesis, Chemical synthesis of sialoglyco-architect... In Vivo Chemistry, Pseudo-Glycoconjugat... with C-Glycoside linkage, Glycoproteins, Boron-Mediated Aglycon Delivery (BMAD) for the Stereoselective Synthesis of 1,2-cis Glycosides, Conformationally Restricted Donors for Stereselective Glycosylation, Yamada’s carbohydrate chemistry, Bacterial Glycolipid Essential for Membrane Protein Integration, and Hidetoshi Yamada: his journey in the carbohydrate world.

  • Plant Bioactives as Natural Panacea against Age-Induced Diseases

    Nutraceuticals and Functional Lead Compounds for Drug Development
    • 1st Edition
    • Kanti Bhooshan Pandey + 1 more
    • English
    Plant Bioactives as Natural Panacea Against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development presents comprehensive information on the complications of aging and the bioactive phytochemicals that in specific herbal formulations, including beverages, can mitigate them. The book extensively describes the current information on the role of plant bioactive components in delaying or preventing the aging process and associated complications, while also covering different strategies and scientific evidence of possible synergistic effects of these studies, enabling the formulation of more effective natural drugs to intervene in aging and associated events. Chapters cover the broad areas of plant bioactive compounds in promoting healthy aging and longevity, including balancing glucose homeostasis, in cognitive impairments, age-related diseases, food trends and the anti-aging diet in Asia and other regions, as well as the social and economic impact of dietary patterns in aging interventions. Written by a team of global experts.

  • Fused Pyrimidine-Based Drug Discovery

    • 1st Edition
    • Raj Kumar
    • English
    Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers the chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates, and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources, and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents and many more. Some of these scaffolds like purines are also known to have involvement in biological processes and are part of the framework of genetic material. This book focuses on the classification, structural chemistry, and chemical and physical properties along with various approaches for their synthesis. This book is ideal for researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 110
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 110, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 75
    • Atta-ur Rahman
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Recent Developments in the Synthesis and Applications of Pyridines

    • 1st Edition
    • Parvesh Singh
    • English
    Recent Developments in the Synthesis and Applications of Pyridines　is a comprehensive　handbo... chemists　working on innovative approaches to the synthesis of pyridines.　Written　b... scientists in both academia and industry and designed to be a standalone reference, the book　features　review... research results and case studies　on　synthetic methods　and　applicat... pyridine-based　chemo... book will　bridge　the gap between industry and academia by presenting　recent innovative approaches to the synthesis of pyridines,　diverse application of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry.　 The role of computational chemistry in the development of pyridine-based bioactive molecules　is also included. This reference is essential for researchers　in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry.　

  • N-Sulfonated-N-Heterocycles

    Synthesis, Chemistry, and Biological Applications
    • 1st Edition
    • Galal H. Elgemeie + 7 more
    • English
    N-Sulfonated-N-Heter... covers the synthesis, chemistry and biological applications of these compounds, focusing on pioneering synthetic approaches, mechanistic insights and their limitations, as well as recent advances in this field. The synthesis of some of N-sulfonated N-heterocycles and their transformation to other useful cyclic and acyclic compounds are discussed, as well as their uses as useful intermediates in the preparation of polymeric and medicinal materials. This book includes detailed methods and protocols, and the focus on applications makes this resource an essential guide for all researchers in the area of organic, medicinal and polymeric synthetic study.

  • Contemporary Chemical Approaches for Green and Sustainable Drugs

    • 1st Edition
    • Marianna Torok
    • English
    Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science.

  • Photochemistry of Heterocycles

    • 1st Edition
    • Maurizio D’Auria + 4 more
    • English
    Photochemistry of Heterocycles is a comprehensive review of the topic, including photooxidation, photoreduction and photoaddition reactions as well as industrial aspects of heterocyclic photochemistry. Many materials used for the manufacturing of OLEDs and other electrooptical switches contain heterocycles, and the use of small molecules or polymers containing heterocyclic substances are being studied as new photovoltaic materials. This reference is ideal for synthetic organic chemists, specifically researchers working in organic photochemistry, as well as medicinal chemists and material scientists. Heterocyclic compounds are widely used in the modern world, and most of the drugs currently in use have heterocyclic nuclei among their constituents. These compounds are subject to a photochemical degradation processes which must be known and prevented.

  • Applications of Nanotechnology in Drug Discovery and Delivery

    • 1st Edition
    • Chukwuebuka Egbuna + 2 more
    • English
    Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials. This book brings together a global team of experts, making it an essential resource for researchers, drug developers, medicinal chemists, toxicologists and analytical chemists.

  • Comprehensive Aryne Synthetic Chemistry

    • 1st Edition
    • Hiroto Yoshida
    • English
    Arynes have been important, well-recognized reactive intermediates in organic chemistry since the first speculation of their existence at the beginning of the 20th century. In recent years, synthetic chemistry with arynes has experienced a remarkable revival, leading to diverse new reactions that provide convenient and direct access to various aromatic compounds of high synthetic significance. Comprehensive Aryne Synthetic Chemistry summarizes the progress in the synthetic utilization of arynes for noncatalytic and transition metal-catalyzed reactions developed in the last 20 years. The book covers a broad range of topics including methods of generating arynes, regioselectivity, electrophilic couplings, pericyclic reactions, transition metal-catalyzed reactions, and cycloadditions. It is ideal for advanced students and researchers working in synthetic organic chemistry in academia and industry.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 74
    • Atta-ur Rahman
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 138
    • Eric F.V. Scriven + 1 more
    • English
    Advances in Heterocyclic Chemistry, Volume 138, the latest release in this definitive series on the field of heterocyclic chemistry, combines descriptive synthetic chemistry and mechanistic insights to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Topics in this new release include The Paal Knorr reaction in Heterocyclic Chemistry, Synthesis and Applications of Heterocyclic Sulfoximines, Recent advances in the synthesis of 4H-chromen-4-ones (2012-2021), Recent Developments in the Chemistry of Heteroporphyrins and Heterocarbaporphyrin... The Chemistry of 1,4-Dihydropyrrolo[3... and more.

  • Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden

    Discovery and Development
    • 1st Edition
    • David E. Lewis
    • English
    Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov’s Rule are addressed. The book introduces Walden’s original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 61
    • David R. Witty + 1 more
    • English
    Progress in Medicinal Chemistry, Volume 61 provides a review of eclectic developments in medicinal chemistry, with each chapter written by an international board of authors.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 108
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 108, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Nephrinuria and podocytopathies, Extracellular vesicles in respiratory disease, Diabetes and cognitive decline, Testosterone analysis in prostate cancer, Mono/polyclonal free light chains as challenging biomarkers for immunological abnormalities, and more.

  • Coronavirus Drug Discovery

    Volume 1: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment
    • 1st Edition
    • Chukwuebuka Egbuna
    • English
    Coronavirus Drug Discovery, Volume 1: SARS-CoV-2 (COVID-19) Prevention, Diagnosis, and Treatment is the first of three volumes presenting comprehensive information on drug discovery against COVID-19. This volume provides background information on the genesis of COVID-19, the epidemiology, transmission, pathogenesis, and mutagenesis. It also presents the various treatment options, drug discovery opportunities and vaccine developmental processes. Written by global team of experts from key institutions across the globe, this book is recommended to all concerned agencies, private research firms, and consortiums working on finding a solution to COVID-19 and its variants. By design, this book will be useful to drug developers, medicinal chemists, pharmacologists, health experts, researchers, students and faculty members in industry and academia.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 73
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 73 covers the synthesis, testing and recording of medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products. Hence, these new discoveries have created new avenues and applications for their use.

  • New Strategies Targeting Cancer Metabolism

    Anticancer Drugs, Synthetic Analogues and Antitumor Agents
    • 1st Edition
    • Galal H. Elgemeie + 1 more
    • English
    New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields.

  • Isolated Pyranones

    Multifaceted Building Blocks for Molecular Diversity
    • 1st Edition
    • Vishnu Ji Ram + 2 more
    • English
    Isolated Pyranones: Multifaceted Building Blocks for Molecular Diversity covers the latest findings on synthesis and chemical reactivity of highly functionalized pyran-2-ones and pyran-4-ones, their reduced analogs and compounds derived from them through chemical reactions, and their applications in drug discovery and material sciences. It covers the mechanisms of the reaction and step by step formation of final products. Numerous pyranones from natural and synthetic origins, as well as their derived products, have shown diverse pharmacological activities and some are in clinical use. The applications of these compounds are not limited to drug development and imaging agents, and they are also used in material science as organic semiconductors, liquid crystals, organic light emitting diodes (OLEDs), organic catalysts, solid state lasers, photovoltaic and photoconductive devices. The book is ideal for organic, bioorganic, physical, material and natural product chemists working to generate diverse molecular entities through ring transformation reactions of pyranones, and those working in material science to generate new chemical entities.

  • Raney Nickel-Assisted Synthesis of Heterocycles

    • 1st Edition
    • Navjeet Kaur
    • English
    Raney Nickel-Assisted Synthesis of Heterocycles covers the synthesis of heterocycles using Raney nickel. The book focuses on the use of Raney-Ni, a common catalyst in hydrogenation reaction and its uses in the synthesis and preparation of heterocycles. Furthermore, it explains how the development of new approaches and strategic deployments in known approaches for the formation of complex heterocyclic compounds continue to drive the field of synthetic organic chemistry, along with updates on efforts to prepare heterocycles through the development of new and efficient synthetic transformations. Heterocyclic chemistry is an inexhaustible source of novel compounds, providing the most diverse chemical, physical and biological properties through the design of a wide range of combinations of carbon, hydrogen and heteroatoms. Significant focus has been paid to novel approaches to the formation of heterocyclic compounds, which are of practical use acting as modifiers and additives in a wide range of industries such as reprography, plastics, cosmetics, vulcanization accelerators, solvents, antioxidants and information storage.

  • Heterocyclic Mesomeric Betaines and Mesoionic Compounds

    • 1st Edition
    • Volume 137
    • English
    Heterocyclic Mesomeric Betaines and Mesoionic Compounds, Volume 137 in the Advances in Heterocyclic Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Heterocyclic Mesomeric Betaines, Type A Mesoionic Compounds (1980-2020), Type B Mesoionic Compounds (1980-2020), Recent Developments in the Chemistry of Heteroporphyrins, Carbaporphyrins and Related Systems, Heterocyclic Zwitterions Based on Coupled Polymethines, Meso-ionic Compounds reproduced from Adv. Heterocycl. Chem. 1976, 19, 1-122., and Meso-ionic Heterocycles (1976-1980) reproduced from Tetrahedron, 1982, 38, 2965-3011.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 107
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 107, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Advances in Quantum Dots as Diagnostic Tools, Host polymorphisms and COVID-19 infection, Biomarkers in Muscle Invasive Bladder Cancer, and more.

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