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Elsevier

Books in Organic chemistry

This collection offers extensive coverage of organic synthesis, reaction mechanisms, and functional group chemistry. Showcasing innovative research, green chemistry approaches, and industrial applications, it supports chemists, students, and researchers in designing new molecules and materials. Addressing drug discovery, polymers, and sustainable processes, these titles foster creativity and technical excellence in advancing organic chemistry for societal benefit.

  • Metal Organic Frameworks for Energy and Environmental Applications

    • 1st Edition
    • Hongyi Gao + 1 more
    • English
    Metal Organic Frameworks for Energy and Environmental Applications presents a comprehensive overview on the application of metal organic frameworks (MOFs) to energy and environmental areas. MOFs are a promising class of materials due to their tunable structures, high surface area, and versatile functionalities, and are capturing the attention of the global scientific community due to their intersection with environmental concerns. Chapters summarize recent research on MOFS and synthesis strategies for catalysis, including photocatalysis, electrocatalysis, and thermal catalysis, and how MOFs offer enhanced performance, selectivity, and efficiency.Additiona... the vital role MOFs play in energy storage, environmental purification, including degradation of harmful agents, and resource utilization is explored. The book also presents new research on machine learning and data mining, including how researchers can leverage datasets and algorithms to discover new, high-performance MOFs. Metal Organic Frameworks for Energy and Environmental Applications will be a valuable reference for those studying and working in the field of MOFs as they apply to energy, environmental technologies, catalysis, and materials science.

  • Progress in Heterocyclic Chemistry

    • 1st Edition
    • Volume 37
    • R. Alan Aitken + 1 more
    • English
    Progress in Heterocyclic Chemistry, Volume 37 is the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. Chapters are all written by leading researchers in their field, brining a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2024.As with previous volumes in the series, this new release enables academic and industrial chemists and advanced students to keep abreast of developments in heterocyclic chemistry in a convenient way.

  • Chalcones and their Derivatives

    From Synthesis to Applications
    • 1st Edition
    • Mohmmad Younus Wani + 3 more
    • English
    Chalcone is a highly versatile scaffold with a broad range of applications. Serving as a precursor for various organic molecules and natural flavonoids, it exhibits significant biological activities and unique physical properties, including semiconductor behavior, non-linear optical effects, fluorescence, and electronic characteristics. Chalcones have attracted considerable research interest due to their pharmacological potential and the ease with which their biological activity and other properties can be modified through subtle structural changes along the α,β-unsaturated backbone. Beyond their medicinal value, chalcones are utilized in the food and cosmetic industries as additives, owing to their UV-protective qualities. Additionally, they serve as chemosensors and probes in analytical applications. The book Chalcones and Their Derivatives: From Synthesis to Applications explores this remarkable molecule, detailing various synthetic methods, its biological significance, and its diverse applications across multiple fields. Serving as both a comprehensive reference for researchers and an essential guide for postgraduate students, this work provides valuable insights into the development and utilization of chalcone-based molecules for a wide array of purposes.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 84
    • English
    Advances in Organometallic Chemistry, Volume 84, the latest release in this longstanding serial, is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. Sample chapter titles in this new release include Grignard-type Reactions for the Synthesis of Calcium-Based Organometallics, Alkylidyne-alkylidyn... coupling reactions and related chemical transformations at a multimetallic site, and Heterocyclic Organogermanium Derivatives, and much more.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 64
    • English
    Progress in Medicinal Chemistry, Volume 64 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Molecular Orbital Theory and Frontier Orbitals for Organic Chemistry

    A Practical Guide
    • 1st Edition
    • Dipak Kumar Mandal
    • English
    Molecular Orbital Theory and Frontier Orbitals for Organic Chemistry: A Practical Guide is a crucial text for students of organic chemistry. This book provides simple, yet quantifiable explanations based on molecular orbital-based reasoning. It seeks to deepen the reader's understanding of long-standing concepts in MO theory, while also formulating new ones through perturbation molecular orbital theory. Written for undergraduates, graduates, and researchers, the book includes many problems with detailed solutions, allowing readers to test their knowledge as they progress through each chapter.The book emphasizes a practical and pedagogical approach, perfected through the authors' extensive teaching experience. It is ideal for those wishing to gain a thorough understanding of molecular orbital theory, from students to seasoned chemists. The text aims to be distinct in its methodology, making it accessible to a wide audience. The inclusion of in-chapter problems helps reinforce learning, ensuring that readers can immediately apply what they have learned. This book serves as an indispensable resource for anyone seeking to master this fundamental aspect of organic chemistry.

  • Drug Discovery Stories, Volume 2

    • 1st Edition
    • Bin Yu + 1 more
    • English
    Drug Discovery Stories, Volume Two showcases the discovery journeys of recent blockbuster drugs approved between 2023 and 2024, along with promising drug candidates. This book delves into structural biology, biological functions of targets, hit compound identification, hit-to-lead optimization, binding modes, key biological and pharmacokinetic data, and clinical results. It also covers other candidate compounds against the same targets and includes additional content based on the authors' choices. The series addresses the rapid evolution in drug discovery and development, appealing to those in chemical biology, synthetic chemistry, and pharmacology.By highlighting interdisciplinary collaboration, the authors plan to release updated editions every few years to ensure the content reflects the latest achievements and breakthroughs in the field.

  • Studies in Natural Products Chemistry Vol 87

    • 1st Edition
    • Atta-ur-Rahman
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 86
    • Atta-ur-Rahman
    • English
    Studies in Natural Products Chemistry, Volume 86 is a comprehensive work that delves into the synthesis, evaluation, and documentation of the medicinal properties found in natural products. The book highlights innovative progress in the discovery, isolation, and analysis of bioactive compounds from both the plant and animal kingdoms. These compounds stem from complex biosynthetic processes shaped over thousands of years by genetic influences. Thanks to breakthroughs in spectroscopic and high-throughput screening techniques, researchers can now quickly identify and assess the structure and biological activity of natural products, opening the door to new pharmaceutical developments.In addition to focusing on isolation and structural analysis, the book explores cutting-edge methods in synthesis, biosynthesis, and pharmacology. It provides readers with up-to-date accounts of advances that fuel new drug discovery and development, making it an essential reference for scientists and professionals in medicinal chemistry, pharmacology, and drug design. The vast chemical diversity covered sets the stage for future innovations in therapeutic research and application.

  • Aziridine Synthesis

    • 1st Edition
    • Navjeet Kaur
    • English
    Aziridine Synthesis delves into the intricate world of aziridine chemistry, offering an in-depth exploration of its diverse methods and applications. This field plays a pivotal role in modern organic and medicinal chemistry, providing invaluable routes for constructing complex molecular architectures. The text emphasizes the versatility and reactivity of aziridines, demonstrating their utility in synthesizing pharmaceuticals and bioactive compounds. By bridging traditional approaches with cutting-edge advancements, the book serves as a comprehensive guide for researchers looking to harness the potential of aziridines in innovative ways.Beyond its focus on methodology, the book also highlights key challenges and breakthroughs in aziridine research. It examines the environmental implications of synthesis techniques, the scalability of reactions for industrial applications, and strategies for harnessing aziridines in drug discovery.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 147
    • English
    Advances in Heterocyclic Chemistry, Volume 147 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. New chapters in this release include Synthesis and chemistry of pyridazin-3(2H)-ones... Denitrogenative Transformations of Polynitrogen Heterocycles, Pyridinium-phenolate Dyes: Preparation and Properties, Recent Advances in the Mechanochemical Synthesis and Derivatization of Heterocycles, Recent Advances in the Synthesis of 7- and 8- Membered Heterocycles via Domino and Multicomponent Reactions (from 20?-2024), and Total Synthesis of Natural Products with Isoflavone Skeletons and Other Heterocycles.

  • Comprehensive Organic Synthesis

    • 3rd Edition
    • Paul Knochel + 1 more
    • English
    Comprehensive Organic Synthesis, Third Edition, Eleven Volume Set builds upon the highly respected previous editions, including the 2nd edition which won the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers. This new edition continues to draw together the common themes that underlie the many disparate areas of organic chemistry, supporting effective and efficient synthetic strategies. With around 200 advanced chapters, it offers a comprehensive overview of this important discipline, making it essential for both experienced practitioners and those new to organic synthesis.This fully revised and updated edition provides an authoritative overview of core concepts, serving as a valuable resource for synthetic chemists requiring essential facts in new areas and students completely new to the field. The work remains an invaluable source for anyone seeking information on solving synthetic problems, ensuring it continues to be an essential reference work for all in the field of organic chemistry.

  • Drug Discovery and One Health Approach in Combating Infectious Diseases

    A Multi-sectoral Approach to address Infections
    • 1st Edition
    • Kanti Bhooshan Pandey + 2 more
    • English
    Drug Discovery and One Health Approach in Combating Infectious Diseases: A Multi-sectoral Approach to address Infections explores the intersection of drug discovery and the One Health Approach, along with the effectiveness of interdisciplinary approaches to combating infectious diseases. The book covers both holistic and innovative drug discovery methodologies and technologies such as natural compounds, harnessing genomics, proteomics, and nanotechnology. Additionally, the book reviews zoonotic diseases, vaccine development, ethical considerations, and regulatory pathways. Practice case studies demonstrate successful One Health and interdisciplinary initiatives to combating infectious disease.This catalogue of knowledge provides a toolbox of innovative and interdisciplinary solutions of complex issues in drug discovery and infectious disease. It will be a valuable resource to professionals and researchers working in the fields of biomedical sciences, pharmaceutical sciences, infectious disease research, and public health, as well as those engaged in drug discovery, development, and the management of infectious diseases.

  • Amines to Azetidines

    • 1st Edition
    • Navjeet Kaur
    • English
    Amines to Azetidines embarks on an insightful journey into the realm of organic synthesis, spotlighting the intricate processes that lead to the formation of azetidines from amine-based compounds. This book serves as a vital resource for chemists, blending theoretical knowledge with practical methodologies. With a focus on clarity, it elaborates on reaction mechanisms, substrate flexibility, and the role of catalysts in facilitating smooth conversions. Designed for readers ranging from seasoned researchers to eager novices, the text combines accessible language with relevant illustrations, ensuring a seamless understanding of fundamental concepts and advanced techniques alike.In addition to its detailed exploration of synthetic routes, the book provides a wealth of examples that underscore the practical applications of azetidines in pharmaceutical and industrial chemistry. It delves into structure-property relationships, offering insights into how subtle chemical modifications influence reactivity and stability. The inclusion of case studies and experimental data makes this work a dynamic blend of academic rigor and real-world relevance.

  • The Alkaloids

    • 1st Edition
    • Volume 94
    • English
    The Alkaloids: Chemistry and Biology, Volume 94, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on topics such as guanidine alkaloids from marine sponges, the chemistry and biology of imidazole, oxazole, and thiazole alkaloids, quinoline and quinazoline alkaloids, pyrazole and indazole alkaloids, and Stemona alkaloids, offering valuable insights into their structures, biosynthesis, and biological activities.

  • Marine Specialized (Secondary) Metabolites and their Diverse Applications

    • 1st Edition
    • Thilina Uduwaka Jayawardena + 1 more
    • English
    Over the past 50 years, more than 20,000 natural compounds have been identified in the marine environment, with an increasing focus on marine metabolites as potential sources for developing effective therapeutic agents. The field of marine drug discovery has seen remarkable growth in recent years, with numerous marine-derived therapeutic candidates in various stages of clinical trials or awaiting approval. The ocean is a potential source of natural products with diverse pharmacological properties, including antimicrobial, anticancer, antiviral, antioxidative, and anti-inflammatory activities. However, commercializing marine natural products has been challenging due to low yields and specificity of specialized (secondary) metabolites. Marine Specialized (Secondary) Metabolites and their Diverse Applications provides a broad overview of marine specialized metabolites and their potential in various industries. With comprehensive coverage, relevance to current trends, interdisciplinary approach, and practical applications, this book includes specific compounds or organisms, with a particular focus on addressing the challenges and limitations associated with them.

  • Azetidine Synthesis

    • 1st Edition
    • Navjeet Kaur
    • English
    Azetidine Synthesis offers a comprehensive exploration of various methods for the synthesis of azetidines, a class of heterocyclic compounds with diverse applications. The significance of azetidine synthesis has grown largely due to the importance of these molecules as constituents of antibiotics. Chapters cover different synthetic pathways, starting with the general synthesis of azetidines and progressing to specific methods using various starting materials. From the copper-catalyzed synthesis of azetidines from nitrones to the synthesis from isoxazoles, oxazines, and diazo compounds, each chapter delves into the unique strategies and mechanisms involved.Rhodium-cat... approaches, cycloaddition reactions of imines to carbonyl compounds, and the use of isocyanides and isocyanates for azetidine synthesis are discussed in detail. The book also explores photochemical methods for azetidine synthesis, including the photochemical synthesis of fused azetidines. By providing a comprehensive overview of diverse synthetic routes to azetidines, this book serves as a valuable resource for researchers and practitioners in the field of organic chemistry, offering insights into the versatility and potential applications of these important heterocyclic compounds.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 83
    • English
    Advances in Organometallic Chemistry, Volume 83, the latest release in this longstanding serial, is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. Chapters in this new release include Pd-catalysis: a useful tool in the field of polymer synthesis. Recent advances and applications, Modern Mechanistic Approaches for the Depolymerization of Commodity Plastics via Homogeneous Metal Catalysis, Functionalization of fullerenes by transition metal catalyzed cyclization reactions, and Synergistic Metal-Ligand Reactivity in Half-Sandwich Complexes of Fe, Co, and Ni for Bond Activation and Catalysis.

  • Antidiabetic Drug Discovery from Natural Products

    • 1st Edition
    • Shailendra S. Gurav + 4 more
    • English
    Antidiabetic Drug Discovery from Natural Products provides up-to-date and in-depth information, practical understanding, and guidance in a comprehensive, systematic and easy-to-understand manner to scientists, researchers, and graduate students on important and emerging biochemical topics related to current antidiabetic drug discovery research. This book analyzes and studies natural active substances and their medicinal chemistry in preventing and treating diabetes and its complications. It covers a wide range of critical issues to assist chemists in the discovery and development of safer, more affordable treatments, from identifying promising leads from medicinal plants to the extraction and synthesis of bioactive compounds.Following an introduction to bioactive chemical compounds from plants with antidiabetic effects, the book describes the discovery and extraction of antidiabetic drugs and antioxidants from natural sources. It also examines antidiabetic plants before delving deeper into the chemistry behind major medicinal substances and their derivatives like Mangiferin and Resveratrol, discussing both current and prospective uses.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 146
    • English
    Advances in Heterocyclic Chemistry, Volume 146 highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Recent Advances in the Synthesis and Reactions of Selenium Heterocycles, Recent advances in the synthesis and reactions of tellurium heterocycles, The Literature of Heterocyclic Chemistry, Part XXII, 2022, Olefin metathesis in the synthesis of benzopyran, benzofuran and flavonoid scaffolds, Bimanes in Retrospect: An In-Depth Analysis of Their Chemical Evolution and Applications of Derivatives Over the Last Half Century, Ring-Fluorination of Heterocycles using Chemical and Electrochemical Methods, and Heterocyclic Zwitterions Based on Coupled Polymethines.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 85
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 85 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts on fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects.With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.

  • The Alkaloids

    • 1st Edition
    • Volume 93
    • English
    The Alkaloids: Chemistry and Biology, Volume 93, the latest release in a series that has been exploring the topic for over 60 years, delves into key aspects of alkaloid chemistry, biology, and pharmacology. This volume discusses the chemistry of quinoline and quinazoline alkaloids, guanidine alkaloids from marine sponges, the chemistry and biology of stemona alkaloids, and the chemistry and biology of pyrazole and indazole alkaloids.

  • Organic Syntheses Based on Name Reactions

    A Practical Encyclopedic Guide to Nearly 800 Transformations
    • 4th Edition
    • Alfred Hassner + 2 more
    • English
    Organic Syntheses Based on Name Reactions is an invaluable reference book for organic chemists in academia and industry. In continuation of Hassner and Namboothiri’s popular 3rd Edition, this new edition with full colored graphics covers nearly 800 reactions, with numerous chemo-, regio- and stereoselective reactions. A diligently prepared summary of important information for each entry allows a chemist to grasp and apply these seminal reactions in their studies and research work. A general scheme, a brief introduction and a representative reaction from the literature with mechanistic outline, a brief procedure, and selected literature references to assist further reading are included in each entry. Besides various indexes (name, reagent, reaction and functional group transformation), a unique overview (in alphabetic order and in terms of reaction category) enable readers to look through the vast repertoire of key organic reactions and an appendix enriched with general information that is extremely useful to students and organic chemistry practitioners are part of this book. Additionally, an online companion site offers preface to previous editions and extensive reference materials. This new edition is very special with its exhaustive coverage, excellent organization and high-quality presentation and is an indispensable resource for every organic chemist.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 84
    • Atta-ur Rahman
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.Studies in Natural Products Chemistry, volume 84 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Phytochemicals for Health

    • 1st Edition
    • Marcello Locatelli + 3 more
    • English
    Phytochemicals for Health presents the state of the art in the field of Phytochemicals. It highlights how, following the interactions of plants and the environment, an analytical approach for standardization and quality control is of fundamental importance to product quality control.Parts I and II cover the main problems relatied to natural products (plants, extraction, quantitative analysis, relationship with the surrounding environment). Part III presents the main classes of organic compounds identified and reported, and Part IV includes inorganic compounds. It also includes a chapter covering all the natural compounds that have become Active Principle Ingredients (API), highlighting next challenges.Phytochem... for Health is a valuable tool for senior scientists working in natural products field interested in investigating the correlation between chemical profile and biological activity in order to obtain a product that is safe for human health.

  • Discovery and Development of Anti-Prostate Cancerous Agents from Natural Products

    • 1st Edition
    • Goutam Brahmachari
    • English
    Discovery and Development of Anti-Prostate Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This new volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogues that show promising potential to act as anti-prostate cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.It will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for prostate cancer, highlighting several key structures from natural products and exploring possible future developments in the area.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 145
    • English
    Advances in Heterocyclic Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Basic to Modern Strategies of Synthetic Organic Chemistry

    • 1st Edition
    • Hyun-Joon Ha
    • English
    Basic to Modern Strategies of Synthetic Organic Chemistry offers fresh perspectives and interests to professionals engaged in organic synthesis in various fields. The book starts with sections for review and understanding of reactions and proceeds with more in-depth knowledge in organic synthesis, including examples of total synthesis. Sections provide a systematic learning of organic reactions, with a focus on the relatively simple yet somewhat complex approach to compound synthesis. Furthermore, this reference will serve as a useful resource for graduate students to enhance their understanding and review of organic chemistry and synthesis.It includes examples of total synthesis that helps pursuing further studies. Additionally, the book provides an introduction to environmental and economic considerations in synthesis, which has become an important issue in recent years, especially for those working in fine chemicals and the pharmaceutical industry. The book also introduces flow chemistry, along with an overview of the processes and equipment used.

  • Antimicrobial Peptides

    A Roadmap for Accelerating Discovery and Development
    • 1st Edition
    • Luis H. Reyes + 2 more
    • English
    Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process of discovery, production, and eventual market penetration of more potent antimicrobial peptides. These efforts have been fueled by emerging technologies such as artificial intelligence and data science, molecular and CFD simulations, easy-to-use process simulation packages, microfluidics, 3D-printing, among many others. Such technologies can now be implemented and scaled up quickly and at relatively low cost in low-budget production facilities, critical to moving to sustainable and marketable products worldwide.Discoverin... novel antimicrobial peptides rationally and cost-effectively has emerged as one of the significant challenges of modern biotechnology. Thus far, this process has been tedious and costly, resulting in molecules with activities far below those needed to address the current challenge of microbial resistance to antibiotics that takes the lives of thousands of people around the world every year. Finally, the book also highlights how multidisciplinary teams have assembled to address the challenges of manufacturing, biological testing, and clinical trials to finally reach complete translation.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 86
    • English
    Advances in Carbohydrate Chemistry and Biochemistry, Volume 86 in this series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 85
    • English
    Advances in Carbohydrate Chemistry and Biochemistry, Volume 85 in this series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Synthesis of Epoxides

    • 1st Edition
    • Navjeet Kaur
    • English
    Synthesis of Epoxides explores different techniques for making epoxides, both old and new, and delves into the growing field of heterocyclic chemistry. The book presents a variety of methods that will help readers figure out which one best suits their specific needs. Diazo compounds are important synthetic intermediates in organic synthesis, but because of their unpredictable, explosive nature and toxicity their unique reactivity has not been fully exploited and their use at large scale has been avoided. Readers, including students in chemistry, will learn about different methods and important information, allowing them to evaluate which method is most suitable in particular cases.The synthetic usefulness of diazo compounds cannot be overlooked despite their danger. Because of their ylide and 1,3-dipole nature, the diazo compounds have a unique reactivity. The diazo compounds can be utilized for various different conversions including S-ylide-assisted epoxidation, cyclopropanation, or aziridination reactions. This book describes the new and classic methods for the synthesis of epoxides and covers an important and rapidly growing branch of heterocyclic chemistry.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 58
    • English
    Advances in Physical Organic Chemistry, Volume 58 is the latest release in this definitive resource for authoritative reviews of work in physical organic chemistry. It aims to provide a valuable source of information not only for physical organic chemists applying their expertise to both novel and traditional problems but also for non-specialists across diverse areas. Its hallmark is quantitative, molecular level understanding of phenomena across a diverse range of disciplines. Sample chapters in this new release include Coacervate formation and the partitioning of molecules into these phases and The area of artificial signal transduction systems.

  • Progress in Heterocyclic Chemistry (PHC)

    • 1st Edition
    • Volume 36
    • R. Alan Aitken + 1 more
    • English
    Progress in Heterocyclic Chemistry (PHC), Volume 36 is the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on new and developing topics of particular interest to heterocyclic chemists. The highlight chapters in this volume are all written by leading researchers in their fields, and these chapters constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2023.As with previous volumes in the series, this update will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way.

  • Human Microbiome Drug Targets

    Modern Approaches in Disease Management
    • 1st Edition
    • Genevieve Dable-Tupas + 3 more
    • English
    Human Microbiome Drug Targets: Modern Approaches in Disease Management presents fundamental information on the human microbiome, looking into the relationship between the microbiome and how it changes with specific diseases. Delving into the multifaceted roles of the microbiome in health and disease, the book's chapters discuss the role of the human microbiome in the pathophysiologic understanding of relevant diseases or disorders and their management. As changes in the human microbiome can provide clues to the probable cause and effect of diseases or disorders, as well as the impacts of therapy or intervention, this book is a welcomed addition to the existing research.Explaining how a better understanding of the microbiome and its impact on health and disease can pave the way for future discoveries leading to better health outcomes, this book will be of interest to drug developers, medicinal chemists, microbiologists, infectious disease specialists, biochemists, and students.

  • Rearrangements with Migration to Electrophilic Heteroatomic Centers

    Timeless Classics in Organic Synthesis
    • 1st Edition
    • Sosale Chandrasekhar
    • English
    Rearrangements with Migration to Electrophilic Heteroatomic Centers: Timeless Classics in Organic Synthesis covers the basic principles and synthetic applications of a critically important class of organic reactions that date back to the founding period of organic chemistry. These reactions are not only of historical and pedagogical interest, but also have great practical value to this day, being inevitable in any strategy concerning the introduction of nitrogen and oxygen functionality. The book is made up of three parts, dealing with the Beckmann reaction, the Hoffmann family of reactions and the Baeyer-Villiger reaction.The book strikes a balance between delineation and exhaustiveness, with up-to-date refences for readers requiring in-depth coverage. Relevant industrial applications, including pharmaceutical processes, are included.

  • The Alkaloids

    • 1st Edition
    • Volume 92
    • English
    The Alkaloids: Chemistry and Biology, Volume 92, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on Renieramycin-type Bis-1,2,3,4-tetrahyd... Marine Natural Products, Structure, activity, and biosynthesis of indolactam alkaloids, and The Chemistry and Biology of Pyrazole and Indazole Alkaloids.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 63
    • English
    Progress in Medicinal Chemistry, Volume 63 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Specific chapters in this release include Harnessing conformational drivers in drug design, Recent Advances in the Medicinal Chemistry of Heterobifunctional Derivatives for Protein Homeostasis, and A Decade of Antimalarial Drug Discovery: New Targets, Tools and Molecules.

  • Advances in Prodrugs

    Design and Therapeutic Applications
    • 1st Edition
    • Claudiu Trandafir Supuran + 2 more
    • English
    Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools.Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 83
    • Atta-ur Rahman
    • English
    Studies in Natural Products Chemistry, Volume 83 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects.With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.

  • Oxazole, Isoxazole, Benzoxazole-Based Drug Discovery

    • 1st Edition
    • Erum Akbar Hussain + 2 more
    • English
    Oxazole, Isoxazole, Benzoxazole Based Drug Discovery offers complete coverage of oxazole and related molecules, both from natural and synthetic origin, with a focus on the reaction mechanisms, and medicinal, pharmacokinetic and computational aspects. New and contemporary methods of synthesis are discussed, with a special focus on green, environment-friendly procedures. Discussion of stereochemical studies, particularly on natural molecules, are included. Computational chemistry has emerged as an integral tool for drug discovery, hence this book explains how the drug candidate is established as suitable for clinical trials with the help of molecular docking and virtual screening modeling.This book offers a broad range of recent developments and detailed coverage of synthesis and biological activities of the drugs, and is an ideal reference guide to researchers working in organic and medicinal chemistry.

  • Organic Synthesis

    • 5th Edition
    • Michael Smith
    • English
    **2025 Textbook and Academic Authors Association (TAA) Textbook Excellence "Texty" Award Winner**Organic Synthesis, Fifth Edition provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, providing them with critical working knowledge of basic reactions, stereochemistry, and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature.There have been advancements in organic reactions, particularly organometallic reactions, and there is a need to show how these advancements have influenced current organic synthesis. The goal is to revise and update the reaction examples taken from the synthesis literature from 2017 to 2023. The reactions illustrate those used most often in modern organic synthesis, but these new examples will show their current relevance. Where new approaches and reactions have been developed for organic synthesis, examples have been added as new material.

  • Visible Light-Driven Organic Synthesis

    • 1st Edition
    • Goutam Brahmachari
    • English
    Visible Light-Driven Organic Synthesis covers the recent cutting-edge investigations in the field of visible light– driven organic synthesis in a single comprehensive volume. It provides information on rigorously selected reaction schemes and covers new reactions and new methods under visible light photocatalysis. It enlists more than 100 important synthetic strategies/methodolo... with particular emphasis on useful reactions for organic synthesis under the mild reaction conditions reported in recent times involving carbon–carbon (C–C) and carbon–heteroatom bond–forming reactions, resulting in a wide spectrum of chemical compounds, providing an outstanding source of information concerning industrial applications.The chapters are classified based on various photocatalysts that have found direct applications in organic synthesis by carrying out different kinds of organic reactions. Each chapter is dedicated to a particular photocatalyst, and each selected reaction is dealt with in a compact manner through point-wise discussion under distinct subheadings covering the reaction type, reaction conditions, bond-forming information, reaction strategy involved, general reaction scheme, examples of representative entries with chemical structures and physical properties, a suggested plausible mechanism, critical views, and literature. In addition, visible light–mediated self-sensitized organic transformations that took place without any external photocatalysts have also been covered.This book is immensely helpful to chemistry students, teachers, researchers, academicians, and chemical/ agrochemical industry people to access the latest information and advances on visible light–driven organic synthesis developments.

  • Specialized Plant Metabolites as Cosmeceuticals

    • 1st Edition
    • Deepika Kathuria + 2 more
    • English
    Specialized Plant Metabolites as Cosmeceuticals presents a comprehensive guide to traditional medicinal plants that are used in the field of cosmetics. Chapters cover geographical distribution, extraction of key components from each plant, traditional uses, pharmacognostic characteristics, phytochemistry, pharmacology, toxicology, and future prospects. This book will be a valuable asset for researchers and graduate students of chemistry, botany, biotechnology, microbiology, cosmetology and the pharmaceutical sciences. As medicinal plants are a rich source of a variety of bioactive secondary metabolites, their wide range of pharmacological applications as antibiotics, antifungals, anticancer agents, and antimicrobial and antiviral applications provide new and exciting avenues.In addition, they have great implications for the food, pharmaceutical, cosmetics and personal care product industries. Secondary metabolites also ecofriendly, cost effective, biocompatible, and cause less side effects as compare to synthetic compounds.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 82
    • Atta-Ur Rahman
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 82
    • English
    Advances in Organometallic Chemistry, Volume 82, the latest release in this longstanding serial, is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. Chapters in this new release include Pd-catalysis: a useful tool in the field of polymer synthesis. Recent advances and applications, Modern Mechanistic Approaches for the Depolymerization of Commodity Plastics via Homogeneous Metal Catalysis, Functionalization of fullerenes by transition metal catalyzed cyclization reactions, and Synergistic Metal-Ligand Reactivity in Half-Sandwich Complexes of Fe, Co, and Ni for Bond Activation and Catalysis.

  • Chemometrics

    Data Treatment and Applications
    • 1st Edition
    • Fabiano AndrĂ© Narciso Fernandes + 2 more
    • English
    Chemometrics: Data Treatment and Applications demonstrates best practices for treating real-world analytical instrument data and how to apply chemometrics to this data. Rather than focusing on the mathematical theory involved in chemometrics, the book is meant for the industrial chemist, academics, and advanced students that want to use chemometrics in practice. Case studies on several applications are presented. Unlike existing literature, this book focuses on best practices, practical realities, and challenges when treating data, rather than on the mathematical theory. It also provides basic information on chemometrics and the best practices used to treat data from different analytical instruments.The book is written primarily for analytic chemists as practitioners in analytical laboratories and other industries. It will also be useful to academics and graduate, masters and postdoc students chiefly working in analytical chemistry who want to improve the practical aspects of their research activities.

  • Fused Pyranones

    Multifaceted Building Blocks for Molecular Diversity
    • 1st Edition
    • Vishnu Ji Ram + 2 more
    • English
    Fused Pyranones: Multifaceted Building Blocks for Molecular Diversity covers the synthesis and chemical reactivity of fused pyranone ring systems, such as coumarin, isocoumarin, chromonone, chroman-4-one, and others, as well as their applications in the fields of drug discovery and material sciences. Mechanisms of the chemical reactions are covered, along with the steps to formation of final products. This book is ideal for organic, medicinal and material chemists and researchers working to build target compounds for pharmaceuticals and materials, as well as those working in food supplements, perfumery, and cell and animal imaging.

  • Herbal Formulations, Phytochemistry and Pharmacognosy

    • 1st Edition
    • Mital Kaneria + 1 more
    • English
    Herbal formulations, Phytochemistry and Pharmacognosy combines the principles of natural medicines with refined modern technology that helps the development of more ecofriendly, better effective, easily available, and affordable drug discovery process.The drug discovery process accelerates the design of new leads for various life-threatening diseases. Natural medicines have been an integral part of drug discovery process, and these not only play a major role as a template for the drug discovery but also offer holistic approach for better management of various diseases.The main purpose of this book is to provide the classical and applied knowledge in drug discovery and broadly cover the related aspects such as herbal formulations, phytochemistry and pharmacogenetic research.

  • Green Approaches in Medicinal Chemistry for Sustainable Drug Design

    Methods
    • 2nd Edition
    • Volume 2
    • Bimal Banik
    • English
    Green Approaches in Medicinal Chemistry for Sustainable Drug Design: Methods, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context on the growth of green chemistry in relation to drug discovery, the book identifies a range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure, and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global experts, the book encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists, and more.This volume covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/ca... and environmentally benign sources, including plants and agricultural materials.

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