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Books in Life sciences

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Targeted Protein Degradation Technologies

  • 1st Edition
  • July 31, 2025
  • Jiangjiang Qin + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 1 8 1 6 - 3
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 1 8 1 7 - 0
Targeted Protein Degradation Technologies provides a thorough overview of targeted protein degradation from the latest developments in the field to potential therapeutic applications. The book begins with an introduction to the mechanisms of protein degradation followed by a section covering both protease-mediate degradation and lysosome-mediate degradation. A range of cutting-edge technologies are covered, including PROTAC, AbTAC, molecular glues, hydrophobic tagging, LYTAC, GlueTAC and AUTAC. Degraders of specific proteins are then investigated, including signal transduction receptors, membrane proteins, and transcription factor degraders.The book closes with a section on the clinical applications of targeted protein degradation and a look at future perspectives. It is a useful resource to those in the fields of molecular biology, cell biology, and related areas working with protein degradation and the development of therapeutic technologies in this arena.

Aging in Ophthalmology

  • 1st Edition
  • July 7, 2025
  • Jorge L Alio MD + 2 more
  • English
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 9 8 4 - 0
Aging in Ophthalmology examines the aging process of the eye and how this affects the future of ophthalmology. With a strong focus on therapeutic options, the book shows the latest improvements in medical and surgical possibilities. It describes both the risks of the aging of the eye, the aging of different parts of the eye (like the retina, lens, and iris), therapeutic approaches to limit the aging processes of the eye, along with a glance into the future. This book is a valuable resource for ophthalmologists of all subspecialties and researchers interested in the aging process in the human eye.

Aquaculture Mycology and Bacteriology

  • 1st Edition
  • July 1, 2025
  • Frederick S.B. Kibenge + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 2 3 5 8 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 2 3 5 9 - 1
Aquaculture Mycology and Bacteriology is a practical reference to address the steadily increasing importance of infectious diseases of aquatic animals. With the burgeoning expansion of the animal aquaculture industry to new geographic areas, new microbial and parasitic species with pathogenic potential will continue to emerge. This necessitates rapid identification of the new pathogens to enable their control. Each pathogenic bacterial or fungal species is accompanied by the full description of both taxonomic and clinical information for the three major aquatic food animals (fish, crustaceans and mollusks). The book takes a comprehensive approach to facilitate research to develop vaccines or other similar pathogen mitigation measures, and is useful to bacteriologists, mycologists, aquaculturists, clinical practitioners in aquatic animal health and all those in industry, government or academia who are interested in aquaculture, fisheries and comparative biology.

Biomarkers in Kidney Transplantation

  • 1st Edition
  • July 1, 2025
  • Dr Smita Pattanaik + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 4 0 6 9 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 4 0 7 0 - 0
Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers.Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.

Flow Cytometry in Immuno-oncology

  • 1st Edition
  • Volume 195
  • July 1, 2025
  • Marcello Pinti + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 8 9 8 8 3 - 6
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 9 8 8 4 - 3
Flow Cytometry in Immuno-oncology, Volume 173 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, Basic principles of Flow cytometry in immuno-oncology, Good practice and methods for flow cytometry in immuno-oncology, Automated flow cytometry in immuno-oncology, Flow cytometric analysis of Tregs in solid tumors, Multiparametric analysis of Tumor infiltrating lymphocytes in solid tumors, Analysis of tumor-infiltrating immune cells in intracranial glioblastoma, Assessing chromosomal abnormalities in leukemias by Imaging flow cytometry, Flow cytometric analysis of cellular alkaline phosphatase in acute myeloid leukemia, and much more.

Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

  • 1st Edition
  • July 1, 2025
  • Theresa Coetzer
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 8 0 1 - 5
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 7 2 0 4 - 8
Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolytic Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.

Glycobiology of the Immune System and Disease

  • 1st Edition
  • July 1, 2025
  • Shyamasree Ghosh
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 8 1 3 - 8
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 7 2 3 9 - 0
Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation.This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, this is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.

Cushing Syndrome

  • 1st Edition
  • July 1, 2025
  • Constantine A. Stratakis
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 6 1 0 0 - 4
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 3 7 0 - 8
Cushing Syndrome: History, Diagnosis, and Treatment is written by top experts on the latest in genetics, molecular advances, and the diagnosis and treatment of Cushing syndrome. The book takes a historical approach to discuss the tremendous and unprecedented research development for this rare condition and includes recently approved medications available. It covers everything from exogenous Cushing syndrome and how to deal with its complications, pseudo-Cushing syndrome (non-tumorous functional hypercortisolemia), endogenous cortisol production and its old and new treatment modalities, from pituitary to adrenal tumors, ectopic ACTH production, subclinical, cyclical Cushing syndrome, to aging and metabolic syndrome.The book has a section dedicated to our patients with the patients’ experiences, which will add to the outcome research presented by the physicians. This is a must have reference for scientists and researchers with the latest information in diagnosing and treating this difficult-to-diagnose and difficult-to-treat condition and gives the clinician, a patient-centric approach to communicate with this particular group of patients.

An Introduction to Ethics, Pathology, and Laboratory Medicine

  • 1st Edition
  • July 1, 2025
  • Ifeoma Perkins
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 3 1 8 8 - 2
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 1 8 7 - 5
An Introduction to Ethics, Pathology, and Laboratory Medicine offers an organized and practical approach to examining dilemmas that occur frequently in pathology and laboratory medicine in a systematic way. This is a unique and novel resource to enable readers to confidently reach potential solutions with strong ethical reasoning that not only furthers quality patient care but honors the good intentions of their care givers. This book is for healthcare providers, instructors, students of allied health services, researchers, laboratory technologists, and members of the healthcare delivery team who utilize pathology and laboratory services. Each chapter is written in a case-based format followed by a discussion section further exploring the ethical dilemmas demonstrated by the cases. The cases are as suitable for practicing pathologists as well as medical school and PhD students and resident and fellows in all stages of clinical and research training.

Heart Failure in the Child and Young Adult

  • 2nd Edition
  • July 1, 2025
  • Joseph Rossano + 5 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 3 2 7 9 - 7
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 2 7 8 - 0
Heart Failure in the Child and Young Adult: From Bench to Bedside, Second Edition highlights unique aspects of heart failure in the young. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure and then progresses through diagnosis, management, treatment, and surgery, finally concluding with advanced special topics, including genetics, self-management, and nanomedicine.This new edition covers advancements in the field, including additional chapters and discussion on biomarkers, neuromuscular disease, quality of life, palliative care, and the impact of COVID-19 in myocarditis and multisystem inflammatory syndrome in children. It will serve as an indispensable reference to basic science researchers in cardiology, pediatrics, cardiologists, and pediatric cardiologists.

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