Books in Toxicology general

Providing a broad overview of toxicological principles, mechanisms, and testing methods, this portfolio supports researchers, regulators, and clinicians. It features foundational concepts, emerging trends, and case studies that underpin safe chemical and drug use.

Mitochondrial Dysfunction
Methods in Toxicology, Vol. 2
1st Edition
Lawrence H. Lash + 1 more
English
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Adverse Reactions to Drugs
2nd Edition
O. L. Wade + 1 more
English
Adverse Reactions to Drugs, Second Edition focuses on the problems posed by the adverse responses to drugs, as well as drug interactions, dosage, and drug metabolism. The publication first tackles adverse reactions and factors which predispose to adverse drug reactions. Topics include dose adjustment, overdose, renal failure, cumulation, side effects, drug allergy, cumulative overdose, and delayed effects. The text then ponders on drug interactions, including renal excretion, drug metabolism, mutual toxicity, and interactions affecting transport to site of action. The manuscript examines adverse reactions in dental practice, drugs used in pregnancy, the neonate, and lactation, and problems for the pharmaceutical industry before marketing a new drug. Discussions focus on ethical problems of drug studies in man, pregnancy, hemorrhage, oxygen toxicity, chloramphenicol, drugs and lactation, drugs used in dental practice, and local anesthetics. The book then elaborates on monitoring adverse reactions to drugs and the therapeutic audit and drug regulatory bodies and their problems. The publication is a valuable source of data for doctors and dentists wanting to focus on research on the adverse reaction to drugs.
Toxicology
Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
1st Edition
Y. Cohen
English
Advances in Pharmacology and Therapeutics, Volume 9: Toxicology is a collection of papers that tackles advances in toxicological research in context of pharmacology. The text first covers reactive metabolites and their implications for toxicology. Next, the selection deals with the experimental and clinical correlations of behavioral toxicology. The text also tackles toxicology and pharmacology of topical application. The book will be of great use to researchers and practitioners of health related disciplines.
Evaluation of Drug Activities
Pharmacometrics
1st Edition
D R Laurence + 1 more
English
Evaluation of Drug Activities: Pharmacometrics, Volume 2 provides information pertinent to the fundamental aspects of pharmacometrics. This book covers a variety of topics, including anticholinesterases, antitussives, cardioactive agents, diuretics, dermatological agents, and estrogens. Organized into 21 chapters, this volume begins with an overview of anticholinesterases and its pharmacological and physiological actions. This text then examines the diversity of methods for evaluating antitussive drugs, which is related to the complexity of cough reflexes. Other chapters consider tests for cardioactive substances of three general classes, namely, the cardiac glycosides, the coronary vasodilators, and the anti-arrhythmics. This book discusses as well the introduction of many diuretics into therapeutic practice during the past years bears witness to the convenience and success of the tests available for assessing drugs of this class. The final chapter deals with drugs affecting lipid levels in plasma. This book is a valuable resource for chemists, physiologists, pharmacologists, and clinicians.
Opiate Receptors and the Neurochemical Correlates of Pain
Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
1st Edition
Susanna Fürst
English
Opiate Receptors and the Neurochemical Correlates of Pain, Volume V, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The congress offered a good opportunity to stimulate discussions and exchange of ideas between scientists from various countries who approach the problem of narcotics and pain mechanisms in different ways. The 27 contributions in this volume have enriched knowledge in this rapidly expanding field of pharmacology. This volume begins with a discussion of opiate receptors. The results suggest the interaction of various morphine-like drugs with different opiate receptor populations. The existence in nerve tissue of specific opiate receptors binding morphine and other opioids has led to the assumption of endogenous ligand for opiate receptors. One section of the present volume is devoted to enkephalins and endorphins, their structure-activity relationships, interactions with transmitter and other systems, their behavioral effects, and to factors controlling their release. Some other aspects of nociception; the pathways involved in the mode of action of different types of analgesics, e.g. narcotics and non-narcotics; and their relations to inflammation and active substances, such as prostaglandins and substance P, are discussed from various aspects.
Pharmacology of Histamine Receptors
1st Edition
C. R. Ganellin + 1 more
English
Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement. The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.
Prostanoids
Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
1st Edition
Valéria Kecskeméti
English
Prostanoids, Volume VI, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. Prostaglandin research is an exciting and rapidly developing field in chemical and biological sciences. It is the recently discovered prostacyclin that has brought about a breakthrough in prostaglandin research giving new impetus to clinical investigation. This volume contains 22 papers read at the ""Prostanoids Symposium"" by participants from eight different countries. Numerous new data concerning the synthesis of prostacyclin and different stable prostacyclin analogues are presented. Besides the problems of synthetic chemistry, data are given about the pharmacological properties of these prostacyclin analogues, analyzing their effects on heat and smooth muscles. Several papers dealing with the involvement of different pharmacologically active agents and hormones in the biosynthesis of prostaglandins emphasize the important role of prostanoids in various pathophysiological processes and diseases. The clinical use of prostacyclin, having already earned an outstanding position in medicine, is stressed.
In Vitro Biological Systems
Methods in Toxicology, Vol. 1
1st Edition
Charles A. Tyson + 1 more
English
Methods in Toxicology, Volume 1: In Vitro Biological Systems, Part A provides basic techniques employed by widely recognized scientists to prepare and maintain the biological components of in vitro model systems. The book discusses the in vitro models of neural and neuromuscular systems; ocular system; respiratory system; cardiovascular system; and gastrointestinal system. The text also describes liver slices; liver hepatocytes; other liver cell systems; proximal tubule fragments; kidney cell culture; reproductive and developmental systems; immune system; and skin. Pharmacologists, toxicologists, cell biologists, physiologists, immunotoxicologists, and molecular toxicologists will find the book invaluable.
Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System
Proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System, Naples, Italy, May 1978
1st Edition
Vincenzo Zappia + 2 more
English
Biochemical and Pharmacological Roles of Adenosylmethionine and the Central Nervous System contains the proceedings of an International Round Table on Adenosylmethionine and the Central Nervous System held in Naples, Italy, on May 2, 1978. The papers explore the biochemical and pharmacological roles of S-adenosylmethionine (SAM), with particular emphasis on its functions in the central nervous system (CNS). This book consists of 13 chapters and opens with an introduction to some novel biochemical aspects of SAM and related sulfur compounds, paying particular attention to transmethylation reactions; polyamine biosynthesis and unusual biological roles of adenosylmethionine; metabolic pathways related to adenosine-sulfur compounds; and transport of adenosylmethionine. The following chapters discuss a number of chemical and biochemical properties of SAM as well as its pharmacological aspects within the CNS. The relation between folate and adenosylmethionine metabolism in the brain is examined, along with the effect of SAM administration on noradrenaline and serotonin metabolism in rat brain; cerebral utilization of adenosylmethionine and adenosylhomocysteine... and antidepressant effects of adenosylmethionine. Methylation in schizophrenia is also considered. This monograph will be a valuable source of information for biochemists and pharmacologists.
Receptors and Centrally Acting Drugs Pharmacokinetics and Drug Metabolism
Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985
1st Edition
E. S. Vizi + 2 more
English
Advances in Pharmacological Research and Practice, Volume 2: Receptors and Centrally Acting Drugs presents the proceeding of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the developments in the fields of receptors and centrally acting drugs as well as in pharmacokinetics and drug metabolism. Organized into two sections encompassing 25 chapters, this volume begins with an overview of prejunctional regulation of neuromuscular transmission. This text then explores the whole-body autoradiography that is used extensively in toxicological research and screening. Other chapters consider the three major classes of models used in pharmacokinetics. This book discusses as well the various aspects of melanin–drug interactions. The final chapter deals with the investigation on the melanin affinity of amphetamine derivatives. This book is a valuable resource for pharmacologists, pharmacokineticists, and researchers.
Drugs and Driving
1st Edition
Herbert Moskowitz
English
Drugs and Driving is a compendium of papers from a symposium of the same title presented at the U.S. Transportation Research Board. This collection reviews the effects of five classes of drugs on driving (amphetamines, tranquilizers, barbiturates, narcotics, cannabis), the other studies being made on drugs and driving, as well as some countermeasure programs against drunk driving. The papers report that amphetamines can induce risky driving behavior, tranquilizers can increase traffic accident risks, barbiturates can degrade driving skills especially when the drug is combined with alcohol, while marijuana use can impair important driving skills. Another paper evaluates drug use and driving risk among high school students in Toronto: results show that the total effect of infrequent use of drugs on accidents is small compared to alcohol use. A study of out-patients in Finland notes that the combined used of alcohol and drugs tend to increase accident frequency. One paper refutes that Alcohol Safety Action Programs in the United States are ineffective. This collection can be helpful for sociologist, psychologists, psychiatrists, traffic safety officers, and heads of urban safety and traffic divisions.
Progress in Chemical Toxicology
Volume 5
1st Edition
Abraham Stolman
English
Progress in Chemical Toxicology, Volume 5 covers topics on the improved isolation and detection procedures and quantitation methods for volatile poisons, stimulants, hallucinogenic drugs, and marihuana. The book discusses the absorption, distribution, and excretion of drugs and poisons and their metabolites; the system for the toxicological analysis of drugs in biological specimens; and the isolation and analysis of phenothiazines. The text also describes the use of fluorescence in toxicology and the toxicology of new synthetic organic polymers used in containers for food, pharmaceutical compounds, and drinkable water. Some microcrystal tests for drugs and advances in polarography as applied to toxicological analysis are also considered. Biochemists, toxicologists, and scientists involved in the study of narcotics will find the book invaluable.
Progress in Chemical Toxicology
Volume 4
1st Edition
Abraham Stolman
English
Progress in Chemical Toxicology, Volume 4 covers the capabilities of paper and thin-layer chromatography to separate closely resembling drugs and some of their metabolites. The book discusses the use of interfering compounds and artifacts in the identification of drugs in autopsy material; paper and thin layer chromatographic techniques for separation and identification of barbiturates and related hypnotics; and the forensic chemical detection of digitalis glycosides. The text also describes the applications of atomic absorption spectrometry to trace metal analyses of toxicological materials; and the toxicology of insecticides, rodenticides, herbicides, and phytopharmaceutical compounds. The combined action of drugs with toxicological implications is also considered. Chemists, toxicologists, biochemists, and forensics will find the book invaluable.
An Introduction to Mechanisms in Pharmacology and Therapeutics
1st Edition
Howard Rogers + 1 more
English
An Introduction to Mechanisms in Pharmacology and Therapeutics aims to provide some extra information and background reading on modes of action of drugs, but it is not meant to replace existing pharmacology textbooks. It also attempts to show the connection between cell biology and the practice of clinical medicine. This book is organized into 13 chapters that discuss drug-receptor interactions and the influence of drugs on the nervous, respiratory, circulatory, and alimentary systems. They also explain the concepts of pharmacogenetics, intracellular control mechanisms, chemotherapy, and the different types of drugs. This book will be of interest to preclinical and clinical medical students and those preparing for Bachelor of Science degree in Pharmacology and others interested in understanding how drugs work.
Drug Safety
Progress and Controversies
1st Edition
Michel Auriche + 2 more
English
Handbook of Toxicologic Pathology
1st Edition
Wanda M Haschek + 1 more
English
This is the first comprehensive reference work on toxicologic pathology, an emerging field that integrates the mechanisms of toxic injury with the resulting pathology. Chapters deal systematically with organ-specific toxic injury, describing the mechanisms of injury, morphological expression of the injury, and evaluation of the pathology. Additional chapters introduce the field to the uninitiated and address such topics as techniques used for morphological evaluation, risk assessment, and regulatory aspects. The Handbook of Toxicologic Pathology will quickly establish itself as the classic reference work in this field for years to come.
Monoamine Oxidases and Their Selective Inhibition
Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
1st Edition
K. Magyar
English
Monoamine Oxidases and Their Selective Inhibition, Volume IV, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The discovery of the selective monoamine oxidase (MAO) inhibitors, such as clorgyline and deprenyl, has given a new impetus to MAO research as well as to the clinical applicability of these compounds. This volume contains 21 papers by researchers and clinicians from eight different countries. It begins with papers on the pharmacological effects and the biochemical mode of actions of deprenyl as well as some other new selective inhibitors. This is followed by communications concerning the biochemical methods applied in the study of the nature of MAO in the mitochondrial membrane. Finally, the neurologists provide an account of their experience with the clinical application of deprenyl, and other inhibitors in Parkinsonian patients. They also discuss the essential role of the dopaminergic mechanism with respect to the disease.
Drug Design
Medicinal Chemistry: A Series of Monographs, Vol. 2
1st Edition
E. J. Ariëns
English
Drug Design, Volume II covers the design of bioactive compounds interacting with enzymes and playing a role in enzyme synthesis. The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design of organophosphate and carbamate inhibitors of cholinesterases. The text also describes the design of reactivators for irreversibly blocked acetylcholinesterase... drug design based on the inhibition of protein synthesis in the context of susceptible enzymic reactions; as well as the role of enzymes and their synthesis as a target for antibiotic action. The rational design of antiviral agents; the design of penicillin; the design of peptide hormone analogs; as well as the advances in the design of diuretics are also considered. The book further tackles the design of biologically active steroids; the rational elements in the development of superior neuromuscular blocking agents; and the design of tumor-inhibitory alkylating drugs. Pharmacologists, chemists, and people involved in drug design will find the book invaluable.
Fungal Toxins
1st Edition
Solomon Kadis + 2 more
English
Microbial Toxins: A Comprehensive Treatise, Volume VIII, Fungal Toxins is devoted to topics related to algal and fungal toxins and includes critically reviewed articles from different experts in related fields. The text is divided into three sections. Section A covers coumarins — its isolation, identification, biological action, natural occurrence, and uses. Section B deals with the epizootiology, clinical characteristics, and pathological findings of Stachybotryotoxicosi... Section C talks about phytopathogenic and helminthosporium toxins, toxic peptides found in Amanita species as well as other mushroom toxins, compounds accumulating in plants after an infection, and ergot. The book is recommended for microbiologists and toxicologists, especially those who would like to know more about the toxins produced by algae and fungi and their effects.
Algal and Fungal Toxins
A Comprehensive Treatise
1st Edition
Solomon Kadis + 2 more
English
Microbial Toxins, Volume VII: Algal and Fungal Toxins reviews research and investigations on algal and fungal toxins. This book discusses the distribution of poisonous dinoflagellates; pharmacology of blue-green algal toxins; control of Prymnesium and detection of toxin in nature; and F-2 (zearalenone) estrogenic mycotoxin from Fusarium. The effect of Fusarium toxins in animals; mycotoxins produced by Fusarium tricinctum NRRL 3249; and mold growth and production and isolation of trichothecenes are also elaborated. This publication likewise covers the chemistry of scirpene toxic substances of Fusarium nivale; isolation of salivation factor; and mammalian toxicity of epidithiadioxopipera... This volume is a useful reference for scientists and graduate students in various disciplines —microbiology, biochemistry, pharmacology, epidemiology, oncology, and related fields.
Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells
1st Edition
T.E. Gram
English
Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.
Poulsson's Text-Book of Pharmacology and Therapeutics
1st Edition
Stanley Alstead
English
Poulsson’s Text-Book of Pharmacology and Therapeutics, Second English Edition covers the considerable progress in understanding the basic principles, applications, and classifications of drugs and other organic compounds of therapeutic interest. This text is divided into six chapters, each dealing with a specific classification of drugs. The first chapter describes the so-called protoplasmic poisons, which are organic substances that are characterized by their specific effects after absorption on the nervous and muscular systems, while local effects are altogether absent or insignificant. The second chapter examines the organic remedies that principally act locally, such as at the point of application, while the action after absorption is unimportant or is not utilized in medicine. The third and fourth chapters explore the main groups containing the inorganic bodies. These chapters demonstrate that the inorganic compounds differ from the organic, whose activity is due to the unchanged entire molecules, and they are subjected to dissociation. The fifth chapter considers the digestive ferments and foodstuffs, while the sixth chapter is concerned with antitoxins and bacterial products. This book will be of value to pharmacologists, pharmacists, researchers, and pharmacology and pharmacy students.
Epidemiology of Leukaemia and Lymphoma
Report of the Leukaemia Research Fund International Workshop, Oxford, UK, September 1984
1st Edition
M. F. Greaves + 1 more
English
Epidemiology of Leukaemia and Lymphoma contains the proceedings of the Leukaemia Research Fund International Workshop held in Oxford, UK, on September 25-27, 1984. Contributors explore the epidemiology of leukemia and lymphoma based on the results of a pilot study that investigated whether careful subdivision of acute lymphoblastic leukemia (ALL) using a standardized panel of monoclonal antibodies would reveal interesting associations between subtypes and particular geographic regions or ethnic groups within regions. This book is comprised of 31 chapters divided into four sections and begins with a discussion on epidemiological approaches to hematological malignancy, paying particular attention to international data collection and interpretation; clusters and associations in cancer epidemiology; and childhood leukemia in Great Britain and the Netherlands. The next section explores the causes of human leukemia and lymphoma as well as the epidemiology of leukemia and lymphoma subtypes in various regions of the world such as Africa, Asia, United States, and Mediterranean region. The final section focuses on practical problems in standardized immunophenotyping of leukemias and lymphomas; immuno-alkaline phosphatase labeling of hematological samples; and detection of surface membrane antigens by a rosette assay using antibody coupled red cells. This monograph will be of value to clinicians and medical practitioners interested in the epidemiology of leukemia and lymphoma.
Recent Advances in the Pharmacology of Toxins
Proceedings of the First International Pharmacological Meeting Stockholm, 22-25 August, 1961
1st Edition
H. W. Raudonat
English
Recent Advances in the Pharmacology of Toxins brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of toxins and addressed topics ranging from antagonists of bradykinin to the mode of the spread of tetanus toxin in experimental animals. This volume is comprised of 28 chapters and begins with an analysis of the effects of toxins from microorganisms on mammalian cellular metabolism and structure, followed by a review of SRS-A, a slow-reacting substance of anaphylaxis, as a potential factor in the symptoms produced by venoms and toxins. Subsequent chapters explore the release of pharmacologically active lipids by enzymes contained in toxins; the structure and function of some enzymes in snake venoms, with reference to disulfide linkages; biochemistry and pharmacology of small-molecular compounds of cobra venom; and the role of ganglioside in the mode of action of tetanus toxin. This book will be of particular value to pharmacologists and physiologists.
Advances in Pharmacological Research and Practice
Proceedings of the 4th Congress of the Hungarian Pharmacological Society, Budapest, 1985
1st Edition
J. Knoll + 1 more
English
Advances in Pharmacological Research and Practice, Volume 1: Pharmacological Protection of the Myocardium presents the proceedings of the 4th Congress of the Hungarian Pharmacological Society, held in Budapest, Hungary in 1985. This book presents a comprehensive view of the development in the fields of pharmacological protection of the myocardium and the pharmacology of the vascular system. Organized into two sections encompassing 70 chapters, this volume begins with an overview of the ischemic biochemical changes with emphasis on the role of cAMP and the protein kinase system. This text then explores the cellular electrophysiological disorders seen in acute myocardial ischemia as well as their pharmacological modification. Other chapters consider the prevention of primary ventricular fibrillation that includes measures aimed at maintaining electrical stability. The final chapter deals with drugs affecting beneficially the pathological lipoprotein levels. This book is a valuable resource for cardiologists and pharmacologists.
Bioreduction in the Activation of Drugs
Proceedings of the Second Biochemical Pharmacology Symposium, Oxford, UK, 25-26 July 1985
1st Edition
P. Alexander + 2 more
English
Bioreduction in the Activation of Drugs covers the proceedings of the Second Biochemical Pharmacology Symposium. The book presents papers that cover the applications of bioreduction in drug activation, along with its concerns. The text first presents materials about enzymology, such as overview of enzyme systems involved in bioreduction of drugs and in redox cycling, and reductive role of glutathione in the redox cycling of oxidizable drugs. Next, the book covers papers on bacterial and parasites infection, which include reduction by the gut microflora of animals and human and reduction of nitroimidazoles in vitro and DNA damage. The remaining articles deal with cancer treatment, such as hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer, and the biological properties of reduced nitroheterocyclics and possible underlying biochemical mechanisms. The text will be of great use to researchers and practitioners of medicine, pharmacology, and biochemistry.
The Physiology and Pharmacology of the Microcirculation
1st Edition
Nicholas A. Mortillaro
English
The Physiology and Pharmacology of the Microcirculation, Volume 2, discusses the microcirculatory function of specific organ systems. The first volume of The Physiology and Pharmacology of the Microcirculation presented some general aspects of microcirculatory function and then concentrated on the microcirculation of a specific organ system, namely, brain, eye, heart, and kidneys. This second and final volume continues the presentation of microcirculatory function of specific organ systems. The book begins with a chapter on the microcirculation of the lungs, with a description of its microcirculatory features and current methods of study. This is followed by separate chapters on the microcirculation of the splanchnic organs. These include the stomach, emphasizing hemodynamics, tissue oxygenation, and control of blood flow; the small and large intestine. Subsequent chapters deal with the microcirculatory responses of both the liver and spleen to different physiological and pharmacological challenges; the microcirculation of the skin, with emphasis on human microcirculation; normal and abnormal microcirculatory dynamics in skeletal muscle; microcirculation of bone; and microcirculation of the salivary glands and exocrine pancreas. The final chapter presents a selective review of pathological events involving the microcirculation, with the emphasis directed toward human diseases.
Pharmacology for Student and Pupil Nurses and Students in Associated Professions
2nd Edition
Bernard R. Jones
English
Pharmacology for Student and Pupil Nurses and Students in Associated Professions, Second Edition reviews the progress made in the realm of therapy and the exploration of the drug trends already established. This book explains certain aspects of the International System of Units (SI) as they concern the nursing sphere. Organized into 25 chapters, this edition begins with an overview of the main routes chosen for administering a drug that are influenced by various factors, such as the condition of patient, speed of action, and convenience. This text then examines the various types of laxatives that induce or aid in evacuation of the bowel. Other chapters consider the various drugs and procedures employed in kidney failure. This book discusses as well the types and uses of intravenous infusions. The final chapter deals with the calculations that need to be performed by the nursing staff. This book is a valuable resource for nurses and student nurses.
Routes of Drug Administration
Topics in Pharmacy
1st Edition
A. T. Florence + 1 more
English
Routes of Drug Administration covers topics about parenteral and enteral routes of drug administration. The book discusses the anatomy and physiology of administration sites; the formulation and design of delivery systems; and other relevant aspects of biopharmaceutics. The text describes pulmonary delivery, nasal, buccal, and transdermal routes of administration for systemic delivery, as well as a number of systems for more localized therapy with antibiotics. Innovative methods of antibiotic administration, such as continuous and intermittent infusion, endotracheal installation, aerosol delivery, antibiotic-impregnat... catheters, antibiotic-containin... bone cement, and beads, are also considered. Senior undergraduate and postgraduate students in pharmacy, medicine, nursing and allied health sciences and practitioners in these fields, as well as other professionals concerned with the preparation and administration of medicines and the monitoring of drug therapy will find the book useful.
Neuropsychopharmacology
Proceedings of the 7th International Congress of Pharmacology, Paris, 1978
1st Edition
C. Dumont
English
Advances in Pharmacology and Therapeutics, Volume 5: Neuropsychopharmacol... contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of neuropsychopharmacol... and cover topics ranging from anti-schizophrenic drugs to drug pathways in depression treatment. Pharmacological interferences with nonstriatal dopaminergic systems are also discussed. This volume is comprised of 21 chapters and opens by considering the nanomolar affinity of pre- and post-synaptic dopamine receptors for neuroleptics. The next section deals with drug pathways in the treatment of depression, with particular reference to the biochemical mechanisms of depressive states and the therapeutic effects of some antidepressants. The following chapters examine dopamine receptors in the nucleus accumbens; modulation of mesolimbic dopamine mechanisms via serotonin and GABA; how mesocortical dopaminergic neurons react to stress; and the behavioral consequences of the interaction between morphine, substance P, and nonstriatal dopamine neurons. This book will be of interest to practitioners in biosciences, pharmacology, physiology, psychology, neurology, and medicine.
Monographs on Fragrance Raw Materials
A Collection of Monographs Originally Appearing in Food and Cosmetics Toxicology
1st Edition
D. L. J. Opdyke
English
Monographs on Fragrance Raw Materials contains a collection of monographs originally appearing in Food and Cosmetics Toxicology from the first issues in 1973 to the last ones in 1978. The monographs are organized in alphabetical order, as a regular feature of Food and Cosmetics Toxicology. This monograph will prove valuable to many readers of Food and Cosmetics Toxicology, as well as to the wider community of scientists and interested consumers.
Clinical Pharmacology
Proceedings of the 7th International Congress of Pharmacology, Paris 1978
1st Edition
P. Duchêne-Marullaz + 2 more
English
Clinical Pharmacology provides a detailed discussion on toxicology. This discussion includes the chemotherapy of parasitic diseases. Some parts of the book focus on topics on immunopharmacology. Such topic as the genetic and environmental factors that contribute to individual’s varying response to drugs is explained. The book covers such topics as the methods and models for the isoniazid acetylation polymorphism. The issues that arise in the administration of drugs in the neonatal period are assessed. Another topic of interest is the effects of diseases on the absorption of drugs. The pharmacokinetic and pharmacodynamic characteristics of a drug are evaluated. The pharmacogenetic investigation amobarbital disposition is presented completely. The book then presents the use and consumption of drugs in different locations and some clinical considerations. The procedures and methods of analysis for such drug are also reviewed . The book can serve as a valuable tool for pharmacists, medical doctors, pediatricians, students, and researchers in the field of medicine.
Thorium-232 and Uranium-238
The Toxicology of Radioactive Substances
1st Edition
A. A. Letavet + 1 more
English
The Toxicology of Radioactive Substances, Volume 4: Thorium-232 and Uranium-238 deals with the toxic properties of two radioactive elements, thorium-232 and uranium-238, as well as their soluble and insoluble compounds. Emphasis is placed on their biological effects and the late sequelae of their administration, especially in the case of insoluble compounds. Some of the results of laboratory studies on the acute and chronic effects of the very poorly soluble uranium compound U3O8 are presented. This volume is comprised of 12 chapters and opens with an overview of certain aspects of the toxicology of insoluble compounds of thorium-232 and uranium-238, followed by a discussion on the comparative toxicity of soluble and insoluble compounds of thorium-232. Subsequent chapters explore the absorption, distribution, and excretion of certain soluble compounds of natural thorium; the behavior of thorium dioxide in rats after intratracheal and intraperitoneal administration; the effect of thorium dioxide on the peripheral blood of rats; and photometric determination of low amounts of thorium in biological materials. Changes in the peripheral blood following chronic and acute poisoning with U308 are also considered. This book will be of interest to chemists and toxicologists.
Viral Interference and Interferon
1st Edition
R. D. Andrews
English
Viral Interference and Interferon details the developments in the control of virus infections by natural means. The book is comprised of eight chapters that discuss various aspects of interferon. The text first introduces the main concepts of the subject matter. The succeeding chapter discusses various concerns about interferon, including the production, nature, mechanisms, and mode of actions. The book also covers interferon in humans and animals, and its significance. The text will be of great use to students of microbiology, virology, genetics, and immunology.
Epidemiology
Proceedings of the 12th International Cancer Congress, Buenos Aires, 1978
1st Edition
Jillian M. Birch
English
Advances in Medical Oncology, Research and Education, Volume III: Epidemiology covers the proceedings of the 12th International Cancer Congress. The title presents papers that deal with the epidemiological aspect of oncology. The first part of the text covers cancer epidemiology, and then proceeds to tackling occupational cancer. Next the selection talks about seroepidemiology and human cancer. The text also details the interaction between genetic and environmental factors in human cancer. The book will be of great use to students, researchers, and practitioners of oncology.
Toxicology and Experimental Models
Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981
1st Edition
H. Yoshida + 2 more
English
Advances in Pharmacology and Therapeutics II, Volume 5: Toxicology and Experimental Models is the fifth of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into six parts, this book begins by elucidating the rational interpretation of species and strain differences in toxicity for the prediction of risk to man. Subsequent parts discuss the chemical interactions resulting in liver and kidney injury; the role of heme synthesis and degradation in predicting drug toxicity; and delayed toxic effects of pre- and perinatal drug exposure. Other chapters describe models of experimental peptic ulcers and therapeutic agents and models and quality control of laboratory animals.
CNS Pharmacology Neuropeptides
Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981
1st Edition
H. Yoshida + 2 more
English
Advances in Pharmacology and Therapeutics II, Volume 1: CNS Pharmacology Neuropeptides contains the proceedings of the Eighth International Congress of Pharmacology held in Tokyo in 1981. This book is the first of a six-volume compilation of the scientific papers of invited speakers. Separating 26 papers as chapters, this book begins with an invited lecture on opioid peptides and their receptors. Other chapters describe opioid peptides and their relevance to central nervous system mechanisms; neuropeptides and related compounds affecting learning and memory; and pharmacological approaches to the study of sleep regulation. This book also explores the importance of kainic acid and related compounds as a pharmacological tool.
Microwave Fixation of Labile Metabolites
Proceedings of an Official Satellite Symposium of the 8th International Congress of Pharmacology Held in Tokyo, Japan, on 25 July 1981
1st Edition
C. Leroy Blank + 2 more
English
Microwave Fixation of Labile Metabolites documents the proceedings of an official Satellite Symposium of the 8th International Congress of Pharmacology held in Tokyo, Japan, on 25 July 1981. The Symposium was entitled ""Drug Effects on Rapidly Metabolized Compounds in the CNS: Rapid Tissue Fixation with Microwave Irradiation."" The volume begins with a discussion of the use of microwave irradiation to study the concentration and interrelationships of neurochemicals in the brain. This is followed by papers on the effects of immobilization on the increases in cerebellar cyclic GMP induced by cold exposure or apomorphine; importance of rapid enzymatic inactivation prior to the determination of endogenous levels of catecholamines; use of glycolic acid to study catecholamines in the brain following microwave irradiation. Also include are studies on methods for preventing the post mortem increase in γ-aminobutyric acid (GABA); the effect of microwave irradiation on catecholamine levels in the central nervous system; and effect of microwave irradiation in the brain histamine level of rats.
The Nervous System
Central Nervous System Drugs
1st Edition
Walter S. Root + 1 more
English
Physiological Pharmacology: A Comprehensive Treatise, Volume I: The Nervous System — Part A, Central Nervous System Drugs focuses on the influence of drugs on the functions of the central nervous system. The selection first offers information on absorption, distribution, and elimination and effects upon physiological systems. Discussions focus on factors that disturb normal sequence of uptake and elimination of volatile drugs; variations in distribution due to systemic effects of anesthetics; factors influencing the uptake of gases by tissues; and theories of general anesthesia. The book also ponders on alcohols, including alcohols acting on the central nervous system; effect of alcohols on and outside the central nervous system; and synergisms and antagonisms between alcohols and other drugs. The publication takes a look at sedatives and hypnotics, effects upon physiological systems, and analgesics and antipyretic drugs. The text also examines non-narcotic analgesics, tranquilizers, and diphenylmethane derivatives. The selection is a vital source of data for readers interested in the effects of drugs on the central nervous system.
Evaluating Alcohol and Drug Abuse Treatment Effectiveness
Recent Advances
1st Edition
Linda Carter Sobell + 2 more
English
Evaluating Alcohol and Drug Abuse Treatment Effectiveness: Recent Advances is a collection of papers that covers the advancement in rehabilitation of individuals with a history of substance abuse. The title aims to find ways in identifying the treatment that best fits a specific patient. The text first provides a historical account of alcohol and drug treatment outcome research. Next, the selection considers the use of multiple measures of life health to assess alcohol treatment. Chapter 3 deals with the behavioral assessment and treatment evaluation of narcotic addiction, while Chapter 4 talks about the evaluation of behavioral and traditional treatment of alcoholics. The fifth chapter tackles the contingency contracting with drug abusers, and the sixth chapter covers the development of a prototype for the evaluation of alcohol treatment. The text also details the problems in alcohol treatment along with the improvement of confidence in treatment of substance abuse. The book will be of great use to behavioral scientists, social workers, and mental health specialists.
Pharmacology of the Coronary Circulation
Volume 10
1st Edition
Natalia V. Kaverina
English
Pharmacology of the Coronary Circulation focuses on the effects of pharmacological substances on the circulation of the heart, physiology of coronary circulation, effects of adrenomimetic, cholinergic, and ganglion-blocking agents, phenothiazine derivatives, analgesics, nitrites, and nitrates on cardiac vessels and results of clinical trials on Chloracizine. The publication first offers information on the physiology of the coronary circulation and the effects of pharmacological substances on the coronary circulation, including myotropic and neutropic substances and other substances. The book then examines the effects of adrenomimetic substances and cholinergic substances on the coronary circulation. The manuscript evaluates the effects of ganglion-blocking substances and analgesic substances on the coronary circulation. Topics include nicotine, etraethylammonium, hexamethonium, pentamine, and mecamine. The publication then takes a look at the effects of phenothiazine derivatives on the coronary circulation; importance of reflex reactions in connection with the development of acute coronary insufficiency; and effects of pharmacological substances on reflex reactions in the coronary vessels. The book is a dependable reference for readers interested in the pharmacology of the coronary circulation.
Classes of Pesticides
1st Edition
Wayland J. Hayes Jr.
English
Handbook of Pesticide Toxicology, Volume 3: Classes of Pesticides focuses on the properties, toxicity, classes, and reactions of pesticides. The selection first offers information on carbamate insecticides, nitro compounds and related phenolic pesticides, and synthetic organic rodenticides. Discussions focus on miscellaneous synthetic organic rodenticides, fluoroacetic acid and its derivatives, mononitrophenols, dinitrophenols, classification of carbamates, and toxicology of anticholinesterase carbamates. The book then examines herbicides and fungicides and related compounds. Topics include nitrogen heterocyclic fungicides not otherwise classified, hydrazines, hydrozones, and diazo fungicides, anilino and nitrobenzenoid fungicides, antibiotics and botanicals, organic phosphorus herbicides, carbamate herbicides, and herbicidal oils and simple aliphatics. The publication elaborates on miscellaneous pesticides, including repellents, synthetic molluscicides, inhibitors of chitin synthesis, chemosterilants, and synthetic acaricides. The selection is a valuable source of data for researchers interested in pesticide toxicology.
Toxicology of Chemical Mixtures
Case Studies, Mechanisms, and Novel Approaches
1st Edition
Raymond S.H. Yang
English
Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content.Emphasis is on low-level, long-term exposure.
Chemical Structure–Biological Activity Relationships: Quantitative Approaches
Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
1st Edition
F. Darvas
English
Chemical Structure-Biological Activity Relationships: Quantitative Approaches, Volume III, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. This volume focuses on the methodological aspects of QSAR. It also aims to inform the reader about the QSAR research conducted in East-European countries. This volume contains 38 presentations organized into six sections. Several lecturers deal with ""real prediction"" cases, i.e. activity estimation prior to the synthesis of the compounds. A particularly abundant section is devoted to the question of how the receptor models can be built up by means of QSAR calculations. Other sections present mathematical models and algorithms which could be applied to improve further the effectiveness of QSAR calculations. As another unique feature, a separate section treats the quantitative aspects of peptide structure-activity relationships—a field seemingly backward despite its evident importance. Hydrophobicity and its influence on biological potency along with the relationship of steric properties and biological activity are also discussed.
Recent Advances in Neuropsycho-Pharmacology
Selected Papers from the 12th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, Göteborg, Sweden, 22-26 June 1980
1st Edition
B. Angrist + 2 more
English
Recent Advances In Neuropsychopharmacol... contains selected papers from the 12th Congress of the Collegium Internationale Neuro-Psychopharmaco... held in Gõteborg, Sweden, 22-26 June 1980. The 47 papers in the volume are organized into six parts. The papers in Part I deal with the subject of psychostimulants in psychiatric research. Topics covered include the effect of chronic d-amphetamine and chronic apomorphine treatment on non-human primate social and solitary behavior; and the behavioral effects of dopamine agonists. Part II assesses the prescription of psychotropic drugs by general practitioners. Part III examines blood platelets as a model system for central monoaminergic neurons. Part IV focuses on anxiety pathways in the brain. Part V considers prospects for a biochemical classification system in psychiatry. Part VI presents pharmacokinetic studies of psychotropic drugs. Part VI contains two papers on the renal function and renal histology of lithium patients on maintenance lithium therapy and pre-lithium patients; and the treatment of refractory schizophrenia.
Epidemiology in Country Practice
1st Edition
William Norman Pickles
English
Epidemiology in Country Practice presents the development of the catarrhal jaundice and myalgia. It discusses the epidemiological and clinical observations of country doctors. It addresses the conditions of life of a country doctor. Some of the topics covered in the book are the appeal to improved medical research; methods of communicating medical research; techniques in acquisition of clinical data; types of diseases of the people living in the country; description of influenza, measles, scarlet fever, whooping-cough, and mumps; and diagnosis and behavior of chicken-pox and shingles. The description of sonne dysentery is fully covered. An in-depth account of the diagnosis, symptoms, and treatment of undulant fever are provided. The characteristic mononucleosis of glandular fever is completely presented. A chapter is devoted to the classification and description of different skin conditions. Another section is focus on the diagnosis of malignant disease. The book can provide useful information to doctors, students, and researchers.
Advances in Drug Research
Volume 12
1st Edition
N. J. Harper + 1 more
English
Advances in Drug Research, Volume 12 covers articles on advances in drug research. The book presents articles on cyclic nucleotides as targets for drug design; the opposing regulatory roles of cyclic nucleotides in the heart; and the integrated control of trematode diseases. The text also includes articles about the chemical and biological studies on indomethacin, sulindac and their analogs; as well as the pharmacokinetics, pharmacodynamics, toxicity, and the effects of bromocriptine. Toxicologists, pharmacologists, physicians, and drug researchers will find the book invaluable.
Annual Review of Chronopharmacology
Volume 2
1st Edition
A. Reinberg + 2 more
English
Annual Review of Chronopharmacology, Volume 2 presents a scholarly means of rapidly communicating findings and developments in chronopharmacology, which is considered a quickly emerging field. This text first discusses aspects and statistical procedures in chronobiology and chronopharmacology. This book then explains circadian and circannual changes in nephrotoxic effects of heavy metals and antibiotics; chronotoxicology and chronopharmacology with emphasis on carcinostatic agents; and chronopharmacology of cardiovascular medications. The chronopharmacology and chronotherapy of asthma are also tackled. This book concludes by explaining the chronopharmacology of antidepressant drugs and of the inflammatory process. This publication will be invaluable to those interested in the field of chronopharmacology.
Biological Response Mediators and Modulators
John Jacob Abel Symposia on Drug Development
1st Edition
J. Thomas August
English
Biological Response Mediators and Modulators explains that the behavior of a cell depends upon the absorption of the ligand, the quantity of functional receptors existing for ligand recognition and binding, and the transduction of the signal through successive intercellular events. The book presents such model systems as the low-density lipoprotein (LDL) receptor, the epidermal growth factor receptor, and the insulin receptor. The LDL receptor is a model for a class of surface receptors that facilitate the cellular application of macromolecules through the process of receptor-mediated endocytosis. The book discusses the general characteristics of receptor-mediated endocytosis. Another topic of interest is the property of growth-related cell surface receptors. The section that follows describes the function of these receptors as tyrosine-specific protein kinases, which is related to the protein yields of some viral oncogenes. The amount of receptors in a cell depends upon the rates of synthesis and inactivation. The book will provide valuable insights for scientists, cytologists, students, and researchers in the field of chemistry.
Essays in Toxicology
Volume 6
1st Edition
Wayland J. Hayes
English
Essays in Toxicology, Volume 6 approaches toxicology by very different routes; two essays with materials (plastics and tobacco alkaloids), one deals with the effects of abnormal pressure, one considers the biochemistry of the lung, and one discusses poison control centers and other mechanisms for limiting the injury done by toxic materials. The book presents essays on the topological problems and untoward effects from plastic devices used in medical applications; the metabolism of tobacco alkaloids; and poisons control center. The text also includes essays on the toxicology of hypobaric and hyperbaric environments; as well as the exploitable biochemical approaches for the evaluation of toxic lung damage. Biochemists, physical chemists, neurophysiologists, epidemiologists, and social scientists will find the book invaluable.