Books in Neuroscience general

Bridging multiple disciplines, this portfolio provides a comprehensive overview of nervous system structure, function, and disorders. Supporting researchers, students, and clinicians, it features foundational theories, interdisciplinary research, and emerging trends that advance understanding of brain and nervous system health.

Neurobiology of the Placebo Effect, Part I
1st Edition
Volume 138
English
Neurobiology of the Placebo Effect, Part I, Volume 138 in the International Review of Neurobiology series, is the first of two volumes that provide the latest placebo studies in clinically relevant models. Placebo responses effects are not merely a psychological, but a complex psycho-neuro-biologi... process that requires activation of distinct brain areas. This book discusses current research and projects on the involved brain circuitry and neurotransmitter systems. Specific chapters cover such topics as pharmacological conditioning of the endocrine and immune system, expectancy modulation of opioid neurotransmission, nocebo effects in visceral pain, and conditioning as a higher-order cognitive phenomenon, amongst other topics.
Signal Processing for Neuroscientists
2nd Edition
Wim van Drongelen
English
Signal Processing for Neuroscientists, Second Edition provides an introduction to signal processing and modeling for those with a modest understanding of algebra, trigonometry and calculus. With a robust modeling component, this book describes modeling from the fundamental level of differential equations all the way up to practical applications in neuronal modeling. It features nine new chapters and an exercise section developed by the author. Since the modeling of systems and signal analysis are closely related, integrated presentation of these topics using identical or similar mathematics presents a didactic advantage and a significant resource for neuroscientists with quantitative interest. Although each of the topics introduced could fill several volumes, this book provides a fundamental and uncluttered background for the non-specialist scientist or engineer to not only get applications started, but also evaluate more advanced literature on signal processing and modeling.
The Molecular and Cellular Basis of Neurodegenerative Diseases
Underlying Mechanisms
1st Edition
Michael S. Wolfe
English
The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.
Neuronal Correlates of Empathy
From Rodent to Human
1st Edition
Ksenia Z. Meyza + 1 more
English
Neuronal Correlates of Empathy: From Rodent to Human explores the neurobiology behind emotional contagion, compassionate behaviors and the similarities in rodents and human and non-human primates. The book provides clear and accessible information that avoids anthropomorphisms, reviews the latest research from the literature, and is essential reading for neuroscientists and others studying behavior, emotion and empathy impairments, both in basic research and preclinical studies. Though empathy is still considered by many to be a uniquely human trait, growing evidence suggests that it is present in other species, and that rodents, non-human primates, and humans share similarities.
Fundamentals of Cognitive Neuroscience
A Beginner's Guide
2nd Edition
Nicole M. Gage + 1 more
English
Fundamentals of Cognitive Neuroscience: A Beginner's Guide, Second Edition, is a comprehensive, yet accessible, beginner’s guide on cognitive neuroscience. This text takes a distinctive, commonsense approach to help newcomers easily learn the basics of how the brain functions when we learn, act, feel, speak and socialize. This updated edition includes contents and features that are both academically rigorous and engaging, including a step-by-step introduction to the visible brain, colorful brain illustrations, and new chapters on emerging topics in cognition research, including emotion, sleep and disorders of consciousness, and discussions of novel findings that highlight cognitive neuroscience’s practical applications. Written by two leading experts in the field and thoroughly updated, this book remains an indispensable introduction to the study of cognition.
Type 2 Diabetes and Dementia
1st Edition
Velandai Srikanth + 1 more
English
Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology.
Neurogenetics, Part II
1st Edition
Volume 148
English
Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses.
Direct versus Indirect Realism
A Neurophilosophical Debate on Consciousness
1st Edition
John R. Smythies + 1 more
English
Direct versus Indirect Realism: A Neurophilosophical Debate on Consciousness brings together leading neuroscientists and philosophers to explain and defend their theories on consciousness. The book offers a one-of-a-kind look at the radically opposing theories concerning the nature of the objects of immediate perception—whether these are distal physical objects or phenomenal experiences in the conscious mind. Each side—neuroscientists and philosophers—offers accessible, comprehensive explanations of their points-of-view, with each side also providing a response to the other that offers a unique approach on opposing positions. It is the only book available that combines thorough discussion of the arguments behind both direct and indirect realism in a single resource, and is required reading for neuroscientists, neurophilosophers, cognitive scientists and anyone interested in conscious perception and the mind-brain connection.
Neurogenetics, Part I
1st Edition
Volume 147
English
Genetic methodologies are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is evolving rapidly and expected to grow in scope as more disorders are linked to specific genetic markers. Part I covers basic genetic concepts and recurring biological themes, and begins the discussion of movement disorders and neurodevelopmental disorders, leading the way for Part II to cover a combination of neurological, neuromuscular, cerebrovascular, and psychiatric disorders. This volume in the Handbook of Clinical Neurology will provide a comprehensive introduction and reference on neurogenetics for the clinical practitioner and the research neurologist.
Neuromodulation
Comprehensive Textbook of Principles, Technologies, and Therapies
2nd Edition
Elliot Krames + 2 more
English
Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies, Second Edition, serves as a comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. Since the publication of the first edition seven years ago, there has been an explosion of knowledge in neuromodulation, optogenetics, bioelectronics medicine and brain computer interfacing. Users will find unique discussions of the fundamental principles of neuromodulation and therapies, and how they are applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The book focuses on comprehensive coverage of spinal cord stimulation, non-interventional and interventional brain stimulation, peripheral nerve stimulation, and the emerging fields of neuromodulation, including optogenetics and bioelectronics medicine.
Handbook of Developmental Neurotoxicology
2nd Edition
William Slikker Jr. + 2 more
English
Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience.
Sixth International Congress of Neurology
Brussels, 21–28 July 1957
1st Edition
L. van Bogaert + 1 more
English
Neurology, Volume 1 presents the proceedings of the First International Congress of Neurological Sciences, held in Brussels, Belgium, on July 21–28, 1957. This book provides information pertinent to the fundamental aspects of neurology. Organized into 107 chapters, this compilation of papers begins with an overview of the significance of genetic factors in multiple sclerosis wherein its occurrence in more than one member of a family have a very limited value. This text then examines the two common disorders, namely, cervical spondylosis and disseminated sclerosis. Other chapters explain the mechanism of demyelination problem in considering the pathology of multiple sclerosis or any of the degenerative diseases of the nervous system. This book discusses as well the commonest types of headaches observed, including tension headache, migraine headache, post-traumatic headache, and those associated with hypertension. The final chapter deals with cerebellar ataxia, chronic respiratory infection, and telangiectasia. This book is a valuable resource for neurologists, psychiatrists, and neuropsychiatrists.
The Rat Brain in Stereotaxic Coordinates: Compact
7th Edition
George Paxinos + 1 more
English
The Rat Brain in Stereotaxic Coordinates Compact, Seventh Edition is a smaller sized (8.5 x 11inch), abridged version of the most referenced work in neuroscience (over 35,000 citations). The compact edition provides the coronal plates and diagrams of the current seventh edition in a smaller, more convenient spiral format and at a student friendly price. This book includes an introduction on current concepts in neuroanatomy, such as neuromeres and brain development. Students and seasoned researchers will find the first major unified nomenclature ontology tree based on development that features coronal photographic plates and juxtaposed diagrams.
Temporal Sampling and Representation Updating
1st Edition
Volume 236
English
Temporal Sampling and Representation Updating, Volume 236, addresses the gap between laboratory studies using static or predictable stimuli and the more complex change that is a characteristic of the real world. Topics in this new volume include a section on Unfolding the time course of emotion perception, Temporal sampling and representation updating for action in interception and grasping tasks, The influence of Cognitive Control and Attention on Temporal Sampling: Lessons from the Attentional Blink, Synchronizing tracking eye movements with the motion of a visual target, and Sampling feature distributions with visual search in heterogeneous displays.
Handbook of Neuroemergency Clinical Trials
2nd Edition
Brett E. Skolnick + 1 more
English
Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development.
Neuromonitoring Techniques
Quick Guide for Clinicians and Residents
1st Edition
Hemanshu Prabhakar
English
Neuromonitoring Techniques: Quick Guide for Clinicians and Residents provides a quick and easy guide to understanding various neuromonitoring equipment. Chapters include intracranial pressure monitoring, EEG-based monitors, evoked potentials and transcranial doppler. This book is written for trainees, clinicians and researchers in the fields of neurosurgery, neurocritical care, neuroradiology, neuroanesthesia and neurology. As specialized neuromonitoring is now routinely done in neurosurgical cases, it provides an important resource for neurologists, neurophysiologists, anesthesiologists and residents who are expected to have theoretical and practical knowledge on different systems. Each monitoring system is discussed separately, with examples, images, reference values and their interpretations.
Intracranial Epidural Bleeding
History, Management, and Pathophysiology
1st Edition
Jeremy Christopher Ganz
English
Intracranial Epidural Bleeding: History, Management, and Pathophysiology examines the history of the concepts underlying the understanding of the clinical features of epidural bleeding. The pathophysiology of epidural bleeding was examined in two PhD theses in the 1980s, with the results published in top international journals. However, these concepts have not been understood by the general neurosurgical community. This book provides a comprehensive overview of how epidural bleeding actually works. It can be used to help improve the interpretation of images during management, and to assess degrees of urgency. This book is written for neurosurgeons, neurologists, cerebrovascular physiologists, trauma surgeons, and medical historians.
The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption
1st Edition
Volume 136
English
The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption, Volume 136 in the International Review of Neurobiology series, provides an overview of the top candidate neuropeptides in the modulation of alcohol and drug abuse, also covering eating disorders and obesity. Topics covered in this latest release include Corticotropin Releasing Factor (CRF) and Addictive Behaviors, Dynorphin/Kappa Opioid Receptor Signaling in Pre-clinical Models of Alcohol, Drug, and Food Addiction, The Role of Ghrelin Signaling in Additive Behaviors, The Role of the Melanocortin System in Drug and Eating Disorders, Substance P and the Neurokinin-1 Receptor: The New CRH, and the Role of Neuropeptide Y (NPY) in Drug and Eating Disorders. The book uniquely highlights the overlapping central mechanisms that contribute to both drug and alcohol abuse and eating disorders.
The Neurobiology of Brain and Behavioral Development
1st Edition
Robbin Gibb + 1 more
English
The Neurobiology of Brain and Behavioral Development provides an overview of the process of brain development, including recent discoveries on how the brain develops. This book collates and integrates these findings, weaving the latest information with core information on the neurobiology of brain development. It focuses on cortical development, but also features discussions on how the other parts of the brain wire into the developing cerebral cortex. A systems approach is used to describe the anatomical underpinnings of behavioral development, connecting anatomical and molecular features of brain development with behavioral development.The disruptors of typical brain development are discussed in appropriate sections, as is the science of epigenetics that presents a novel and instructive approach on how experiences, both individual and intergenerational, can alter features of brain development. What distinguishes this book from others in the field is its focus on both molecular mechanisms and behavioral outcomes. This body of knowledge contributes to our understanding of the fundamentals of brain plasticity and metaplasticity, both of which are also showcased in this book.
Brain Research in Addiction
1st Edition
Volume 235
English
Brain Research in Addiction, Volume 235, the latest volume in this groundbreaking series on addiction, presents the neurobiological, pathological, cognitive and evolutionary aspects of addiction, with new chapters covering the Neurobiology of drug intake escalation, the Role of the orexinergic system in reward, Mental time travel and addictive behaviors, An evolutionary perspective on addiction- Addiction is the price we pay for innovation and adaptability, and how Cocaine exposure affects object-place recognition memory in non-human primates. Chapters in this serial are presented by leading researchers from North America, South America, Europe, Africa, Asia and Australia, who present addiction research from the bottom up, including how addiction evolved, basic research on animal models, and the psychiatric, psychological and cognitive characteristics of addictive behaviors in humans.
Sport and the Brain: The Science of Preparing, Enduring and Winning, Part B
1st Edition
Volume 234
English
Sport and the Brain: The Science of Preparing, Enduring and Winning, Part B, Volume 233 reflects recent advancements in the understanding of how elite athletes prepare for, and perform at, peak levels under the demands of competition. Topics discussed in this new release include a section on Exploring the Applicability of the Contextual Interference Effect in Sports Practice, The Resonant System: Linking Brain-body-environme... in Sport Performance, the Effects of Acute High-intensity Exercise on Cognitive Performance in Trained Individuals: A Systematic Review, Moving Concussion Care to the Next Level: The Emergence and Role of Concussion Clinics in the UK, and Neurocognitive Mechanisms of the Flow State. This longstanding series takes a multidisciplinary approach, focusing on aspects of psychology, neuroscience, skill learning, talent development and physiology.
Environmental Causes and Prevention Measures for Alzheimer’s Disease
1st Edition
George J. Brewer
English
Environmental Causes and Prevention Measures for Alzheimer’s Disease examines the increased incidence of the disease in developed countries and aims to educate neuroscientists, medical practitioners and other educated individuals on new insights into environmental causation, primarily metals. This book looks into the web of evidence around the hypothesis of copper toxicity and the additional role that a high fat diet plays in disease progression and cognition loss. The data and its implications are discussed, along with potential prevention measures. This book will generate excitement and interest among neuroscientists, medical practitioners and other biomedical researchers.
Neuroepidemiology in Tropical Health
1st Edition
Pierre-Marie Preux + 1 more
English
Neuroepidemiology in Tropical Health covers major neurological diseases of relevance in tropical settings and examines the specificities of epidemiology of neurological diseases in the context of tropical countries that face many challenges when compared to the developed world. Part One focuses on methods and their eventual specificities, and how such methods, like sampling, can be adapted for specific scenarios. Parts Two and Three discuss environmental factors and their consequences for neurology in the tropical world, as well as large geographical areas and their specificities. Finally, Part Four presents relevant neurological diseases in in-depth chapters. This invaluable information will help readers recognize the various neurological conditions presented, with the inclusion of their aetiologies and treatment in tropical areas. The book therefore fills a gap in the neuroepidemiology literature, with chapters written by an international collection of experienced authors in the field.
Chordomas and Chondrosarcomas of the Skull Base and Spine
2nd Edition
Griffith R. Harsh IV + 1 more
English
Chordomas and Chondrosarcomas of the Skull Base and Spine, Second Edition, is a major reference and guide for neurosurgeons, medical oncologists, neuroscientists, orthopedic surgeons, head and neck surgeons and radiation oncologists that treat patients and research chordomas and chondrosarcomas of the axial skeleton. This book is the unique result of the collaboration of multidisciplinary specialists from a wide variety of fields (neurological sciences, medical oncology, molecular biology, orthopedics and radiation oncology), offering the most relevant information about chordomas and chondrosarcomas of the axial skeleton from each of these fields condensed into one single volume. It contains new medical knowledge and scientific advances regarding the treatment of these types of tumors. Additionally, the book includes chapters written by the Chordoma Foundation and Sarcoma Foundation of America, providing the most valuable information and support for patients and their relatives.
Vital Models
The Making and Use of Models in the Brain Sciences
1st Edition
Volume 233
English
The use of models has been important to the historical and contemporary study of the human brain, yet very little study by social scientists has been dedicated to how the brain sciences develop and use models to better understand what brains are and how they work, including the complex entanglements between brains, bodies and their environments. Vital Models: The Making and Use of Models in the Brain Sciences explores the history and use of brain models from clinical psychiatry to psychopharmacology and cybernetics, as well as developments in digital brain modeling, simulation, imaging and connectomics. This timely volume helps both scientists and students better understand the variety, strengths, weaknesses and applicability of models in neuroscience.
Neurobiology of Chinese Herb Medicine
1st Edition
Volume 135
English
Neurobiology of Chinese Herb Medicine, Volume 135 is a valuable book for anyone interested in alternative medicine or the scientific research surrounding ancient herbal medicine. This updated volume in the series includes chapters that delve into timely topics, including the Effects of Lycium Barbarum on the Visual System, the Effect of Chinese Herbal Medicine on Alzheimer’s Disease, the Effect and Mechanism of Chinese Herbal Medicine on Parkinson’s Disease, the Neurobiology of Chinese Herbal Medicine on Major Depressive Disorder, the Treatment of Insomnia with Traditional Chinese Herbal Medicine, and the Metabolic Factors and Adult Neurogenesis: Impacts of Chinese Herbal Medicine on Brain Repair in Neurological Diseases. This series is ideal for Chinese herbal medicine practitioners who are working in a clinical environment, although the clinical applications of Chinese medicinal herbs presented provide useful references and guidance for any clinical practice that specializes in the treatment of various conditions.
Nonmotor Parkinson's: The Hidden Face
Management and the Hidden Face of Related Disorders
1st Edition
Volume 134
English
Non-motor Parkinson's: The Hidden Face-Management and the Hidden Face of Related Disorders, Volume 134, the latest release in the International Review of Neurobiology series, is an up-to-date and comprehensive textbook addressing non-motor aspects of Parkinson’s disease, a key unmet need. Specific chapters in this updated release include Therapeutics and NMS in PD, Non-motor effects of conventional and transdermal therapies in PD, Infusion therapy, CDD and NMS in PD, DBS and NMS in PD, TMS and implications for NMS in PD, Botulinum toxin therapy and NMS in PD, and Nutrition and NMS in PD, amongst others. Including practical tips for non-specialists and clinical algorithms, the book contains contributions from over 40 opinion leaders in the field of movement disorders. It provides practitioners and researchers with a laboratory, to bedside, to caregiver perspective.
Nonmotor Parkinson's: The Hidden Face
The Many Hidden Faces
1st Edition
Volume 133
English
Non-motor Parkinson's: The Hidden Face, Volume 133, the first part of the latest volume in the International Review of Neurobiology series, is an up-to-date, comprehensive textbook addressing the non-motor aspects of Parkinson’s disease, a key unmet need. Chapters in this new release include topics such as The hidden face of Parkinson's, JP and non-motor symptoms, Parkinson's: a complex non-motor disease, Neuropathology of NMS of PD, Neurophysiology and animal models related to NMS in PD, Epidemiology of NMS in PD (cohort studies), Genes and NMS in PD, NMS in genetic forms of PD, and Imaging the NMS in PD. Including practical tips for non-specialists and clinical algorithms, this book contains contributions from over 40 opinion leaders in the field of movement disorders, covering the topic from laboratory, to bedside, to caregiver.
Neurological Problems
1st Edition
Jerzy Choróbski
English
Neurological Problems describes the clinical and pathological aspects of numerous neurological disorders. This book is organized into four parts encompassing 69 chapters. The opening part provides an introduction to the close relationship between the central nervous system and the categories of pathological reactions in man. The next parts deal first with certain problems concerning peripheral vasomotor activity, followed by discussions on neurophysiological mechanisms and chemical aspects of neurological problems. The last part presents considerable clinical manifestations and case studies of these problems. This book is of value to neurologists, neurophysiologists, pathologists, and clinicians.
Latent Syphilis and the Autonomic Nervous System
2nd Edition
Griffith Evans
English
Latent Syphilis and the Autonomic Nervous System, Second Edition describes the link between the pathogenesis of syphilis and the autonomic nervous system. This book is composed of 15 chapters, and begins with a brief introduction to the pathology of syphilis, followed by chapters on the physiologic changes in the thyroid gland, including thyroid enlargement and goiter formation, in early syphilis. The succeeding chapters are devoted to syphilis-related diseases, such as allergy, asthma, vasomotor disturbances, dysphagia, dyspepsia, cancer, and superficial ulceration of the mouth. A chapter describes some clinical features in latent syphilis. The final chapter examines the clinical manifestations of pes cavus, which is both an acquired and congenital disease. This book is of value to pathologists, endocrinologists, clinicians, and medical researchers.
Neurobiological Background of Exploration Geosciences
New Methods for Data Analysis Based on Cognitive Criteria
1st Edition
Paolo Dell'Aversana
English
Neurobiological Background of Exploration Geosciences: New Methods for Data Analysis Based on Cognitive Criteria examines the neurobiological background of earth science disciplines. It presents the fundamental features of the human brain that form the cognitive basis of exploration geophysics and investigates how their analysis can drive the development of new brain-based technologies. Crucial aspects of human cognition include the impulse to explore the environment, the ability of our brain to create mental maps and virtual images of the world, and the human ability to recognize, integrate and save patterns of information in a shared memory. Geoscience technology can be made more effective by taking the working neurobiological principles of our brains into account. This book is appropriate for multiple audiences, including neuroscientists, cognitive scientists and geoscientists, presenting both theoretical and experimental results.
Nanotechnology Methods for Neurological Diseases and Brain Tumors
Drug Delivery across the Blood–Brain Barrier
1st Edition
Yasemin Gürsoy Özdemir + 2 more
English
Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors.
Noradrenergic Signaling and Astroglia
1st Edition
Nina Vardjan + 1 more
English
Noradrenergic Signaling and Astroglia integrates what is known about the active role of astroglia in the locus coeruleus-noradrener... system and outlines the most recent advances in the field. It discusses the molecular mechanisms underlying norepinephrine-induc... receptor activation in astroglia, cellular metabolism and CNS energy provision, in vitro, ex vivo, and in vivo models, gliosignalling and neuronal activity, and astroglial networks, gap junctions, and morphological plasticity. The book also addresses the role of astroglial adrenergic receptor activation in memory formation, cognition, regulation of sleep homeostasis, and lastly in neurological disorders, including trauma (cellular edema), neurodegeneration (Alzheimer’s disease), and neuroinflammation (multiple sclerosis). Noradrenergic Signaling and Astroglia is a valuable source of new knowledge for a wide audience, including graduate students, post-doctoral fellows, and researchers in neuroscience, life sciences, and the biological and biomedical sciences.
Brain Edema
From Molecular Mechanisms to Clinical Practice
1st Edition
Jerome Badaut + 1 more
English
Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment. Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma. In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective.
Learning and Memory: A Comprehensive Reference
2nd Edition
John H. Byrne
English
Learning and Memory: A Comprehensive Reference, Second Edition, Four Volume Set is the authoritative resource for scientists and students interested in all facets of learning and memory. This updated edition includes chapters that reflect the state-of-the-art of research in this area. Coverage of sleep and memory has been significantly expanded, while neuromodulators in memory processing, neurogenesis and epigenetics are also covered in greater detail. New chapters have been included to reflect the massive increase in research into working memory and the educational relevance of memory research. No other reference work covers so wide a territory and in so much depth.
Rhythmic Stimulation Procedures in Neuromodulation
1st Edition
James R. Evans + 1 more
English
Rhythmic Stimulation Procedures in Neuromodulation offers a unique approach to rhythm-related stimulation as it pertains to modulating neural functioning, with the goal of alleviating symptoms of mental disorder. Rhythm and related concepts (frequency, resonance, entrainment) are thought by many to be closely linked to human health and disease. Neurologists and clinical psychologists facilitate neuroplasticity by using pulsed (rhythmic) sensory or electromagnetic stimulation—a group of techniques broadly referred to as neuromodulation. This edited volume describes details of rhythm-related neuromodulation techniques, and experts in the field have detailed the pros and cons of each approach, citing both clinical and scientific support. Each technique chapter provides a detailed description of the procedure, a rationale for application with specific populations, discussion of similarities/differe... relative to other approaches, and support for efficacy. This volume offers readers a historical overview of the roles of rhythm and dysrhythmia in health and disease, including examples of past and present therapeutic uses of rhythmic stimulation, entrainment, and/or modification. It also facilitates speculation about potential developments in rhythm-related methods for the future of mental health. Few books published in the general area of rhythm have focused on the scientific study of the significance of biological rhythms.
Institutional Neurosis
2nd Edition
Russell Barton
English
Institutional Neurosis is a four-chapter text that systematically presents the dreadful mental changes that may result from institutional life and the steps that can be taken to cure them. The term “institutional neurosis” promotes the syndrome to the category of a disease, rather than a process, thereby encouraging the public to understand, approach, and deal with it in the same way as other diseases. The opening chapter describes the clinical features of the disorder in mental hospitals, its differential diagnosis, etiology, treatment, and prevention. The next chapters consider the etiology or factors associated with institutional neurosis, including apathy, loss of interest, lack of initiative, and sometimes a characteristic posture and gait. The last chapter reviews the various aspects of the treatment of institutional neurosis. This book is of value to neurologists, psychologists, psychiatrists, and researchers in the allied fields.
The Rewiring Brain
A Computational Approach to Structural Plasticity in the Adult Brain
1st Edition
Arjen van Ooyen + 1 more
English
The adult brain is not as hard-wired as traditionally thought. By modifying their small- or large-scale morphology, neurons can make new synaptic connections or break existing ones (structural plasticity). Structural changes accompany memory formation and learning, and are induced by neurogenesis, neurodegeneration and brain injury such as stroke. Exploring the role of structural plasticity in the brain can be greatly assisted by mathematical and computational models, as they enable us to bridge the gap between system-level dynamics and lower level cellular and molecular processes. However, most traditional neural network models have fixed neuronal morphologies and a static connectivity pattern, with plasticity merely arising from changes in the strength of existing synapses (synaptic plasticity). In The Rewiring Brain, the editors bring together for the first time contemporary modeling studies that investigate the implications of structural plasticity for brain function and pathology. Starting with an experimental background on structural plasticity in the adult brain, the book covers computational studies on homeostatic structural plasticity, the impact of structural plasticity on cognition and cortical connectivity, the interaction between synaptic and structural plasticity, neurogenesis-related structural plasticity, and structural plasticity in neurological disorders. Structural plasticity adds a whole new dimension to brain plasticity, and The Rewiring Brain shows how computational approaches may help to gain a better understanding of the full adaptive potential of the adult brain. The book is written for both computational and experimental neuroscientists.
Models of Seizures and Epilepsy
2nd Edition
Asla Pitkänen + 3 more
English
Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.
Functional Neural Transplantation IV
Translation to Clinical Application, Part B
1st Edition
Volume 231
English
Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery. New to this edition are chapters on Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy, Transplantation of GABAergic Interneurons for Cell-Based Therapy, Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch, From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials, and the Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, while also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.
Functional Neural Transplantation IV
Translation to Clinical Application, Part A
1st Edition
Volume 230
English
Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.
Neuroscience Basics
A Guide to the Brain's Involvement in Everyday Activities
1st Edition
Jennifer L. Larimore
English
Neuroscience Basics: A Guide to the Brain’s Involvement in Everyday Activities examines how our brain works in everyday activities like sleeping, eating, love, and exercise. Many want to better understand how the brain works, but the terminology and jargon of books can be overwhelming. The book covers the basics taught in an introductory neurobiology course designed for anyone new to the neuroscience field, including non-neuroscientists. While each of the chapters explore the brain in a normal state, Neuroscience Basics also discusses disruptions of the normal state—psychosis, Alzheimer’s, Parkinson’s, autism, learning disorders, etc. This book breaks down the topics into language that is more accessible while making the neuroscience topics fun and relevant.
Biometals in Neurodegenerative Diseases
Mechanisms and Therapeutics
1st Edition
Anthony R. White + 3 more
English
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.
A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease
1st Edition
Paul J. Marangos
English
Cancer, dementia, and cardiovascular disease are responsible for almost two million deaths each year in the United States alone and represent the largest immediate threat to humanity. Over the last century, we have made spectacular advances that have transformed our society – splitting the atom, space travel, telecommunications, and the Internet – but with medical research focused mostly on science for the sake of science, it has yielded precious few cures. A Roadmap for Curing Cancer, Alzheimer’s, and Cardiovascular Disease represents a "first of its kind" effort to address both the reasons for this and to posit solutions to fix our broken system, in an effort to finally end this cure crisis. Dr. Marangos draws on 45 years of experience in every aspect of the biomedical R&D field, from basic drug discovery research at the NIH to the co-founding of five drug companies. He has published 252 research papers and edited four books on drug discovery, is co-inventor on 14 patents, and founded "The Journal of Molecular Neuroscience". He argues that from a development perspective, the regulatory, patent, and legal hurdles that force industry to pursue so-called "me-too" drugs rather than cures for terminal diseases must be re-thought. Leadership accountability, strategy, focus, and urgency need to be re-evaluated, and major reforms to the NIH, FDA, and patent codes are proposed.to remedy these impediments to cures. Written for anyone frustrated with the seemingly endless threat of terminal disease, this book seeks to inform, energize, and provide the rationale for the public and industry stakeholders, as well as clinicians and researchers, to resurrect the physician-patient relationship and demand that we get serious about ridding society of this scourge on humanity. This work contains the views and opinions of the author and are in no way intended to harm the reputation of any person, agency, organization, or commercial entity discussed herein. www.cureterminaldise...
Primer on Cerebrovascular Diseases
2nd Edition
Louis R. Caplan + 6 more
English
Primer on Cerebrovascular Diseases, Second Edition, is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, presenting the information in a comprehensive and easily accessible manner. Numerous changes have occurred in the field since the publication of the first edition in 1997, particularly our understanding of the genetic aspects of cerebrovascular disease. This updated edition reflects the advances made over the last two decades, not only demonstrating the promise for therapy, but also for a molecular understanding of cerebrovascular diseases. The new edition includes new and expanded topics, including carotid stenting, Iatrogenic causes of stroke, axonal transport and injury, RNAIs, proteomics, and more. 2018 BMA Medical Book Awards Highly Commended in Neurology.
The Human Sciences after the Decade of the Brain
1st Edition
Jon Leefmann + 1 more
English
The Human Sciences after the Decade of the Brain brings together exciting new works that address today’s key challenges for a mutual interaction between cognitive neuroscience and the social sciences and humanities. Taking up the methodological and conceptual problems of choosing a neuroscience approach to disciplines such as philosophy, history, ethics and education, the book deepens discussions on a range of epistemological, historical, and sociological questions about the "neuro-turn" in the new millennium. The book’s three sections focus on (i) epistemological questions posed by neurobiologically informed approaches to philosophy and history, (ii) neuroscience’s influence on explanations for social and moral behavior, and (iii) the consequences of the neuro-turn in diverse sectors of social life such as science, education, film, and human self-understanding. This book is an important resource both for students and scholars of cognitive neuroscience and biological psychology interested in the philosophical, ethical, and societal influences of—and on—their work as well as for students and scholars from the social sciences and humanities interested in neuroscience.
Mathematics for Neuroscientists
2nd Edition
Fabrizio Gabbiani + 1 more
English
Mathematics for Neuroscientists, Second Edition, presents a comprehensive introduction to mathematical and computational methods used in neuroscience to describe and model neural components of the brain from ion channels to single neurons, neural networks and their relation to behavior. The book contains more than 200 figures generated using Matlab code available to the student and scholar. Mathematical concepts are introduced hand in hand with neuroscience, emphasizing the connection between experimental results and theory.
Evolution of Nervous Systems
2nd Edition
Jon H. Kaas + 5 more
English
Evolution of Nervous Systems, Second Edition, Four Volume Set is a unique, major reference which offers the gold standard for those interested both in evolution and nervous systems. All biology only makes sense when seen in the light of evolution, and this is especially true for the nervous system. All animals have nervous systems that mediate their behaviors, many of them species specific, yet these nervous systems all evolved from the simple nervous system of a common ancestor. To understand these nervous systems, we need to know how they vary and how this variation emerged in evolution. In the first edition of this important reference work, over 100 distinguished neuroscientists assembled the current state-of-the-art knowledge on how nervous systems have evolved throughout the animal kingdom. This second edition remains rich in detail and broad in scope, outlining the changes in brain and nervous system organization that occurred from the first invertebrates and vertebrates, to present day fishes, reptiles, birds, mammals, and especially primates, including humans. The book also includes wholly new content, fully updating the chapters in the previous edition and offering brand new content on current developments in the field. Each of the volumes has been carefully restructured to offer expanded coverage of non-mammalian taxa, mammals, primates, and the human nervous system. The basic principles of brain evolution are discussed, as are mechanisms of change. The reader can select from chapters on highly specific topics or those that provide an overview of current thinking and approaches, making this an indispensable work for students and researchers alike.
Conn's Translational Neuroscience
1st Edition
P. Michael Conn
English
Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.
Decision Neuroscience
An Integrative Perspective
1st Edition
Jean-Claude Dreher + 1 more
English
Decision Neuroscience addresses fundamental questions about how the brain makes perceptual, value-based, and more complex decisions in non-social and social contexts. This book presents compelling neuroimaging, electrophysiological... lesional, and neurocomputational models in combination with hormonal and genetic approaches, which have led to a clearer understanding of the neural mechanisms behind how the brain makes decisions. The five parts of the book address distinct but inter-related topics and are designed to serve both as classroom introductions to major subareas in decision neuroscience and as advanced syntheses of all that has been accomplished in the last decade. Part I is devoted to anatomical, neurophysiological, pharmacological, and optogenetics animal studies on reinforcement-guided decision making, such as the representation of instructions, expectations, and outcomes; the updating of action values; and the evaluation process guiding choices between prospective rewards. Part II covers the topic of the neural representations of motivation, perceptual decision making, and value-based decision making in humans, combining neurcomputational models and brain imaging studies. Part III focuses on the rapidly developing field of social decision neuroscience, integrating recent mechanistic understanding of social decisions in both non-human primates and humans. Part IV covers clinical aspects involving disorders of decision making that link together basic research areas including systems, cognitive, and clinical neuroscience; this part examines dysfunctions of decision making in neurological and psychiatric disorders, such as Parkinson’s disease, schizophrenia, behavioral addictions, and focal brain lesions. Part V focuses on the roles of various hormones (cortisol, oxytocin, ghrelin/leptine) and genes that underlie inter-individual differences observed with stress, food choices, and social decision-making processes. The volume is essential reading for anyone interested in decision making neuroscience. With contributions that are forward-looking assessments of the current and future issues faced by researchers, Decision Neuroscience is essential reading for anyone interested in decision-making neuroscience.