Books in Molecular biology cellular biology and genetics

Formation and Fate of Cell Organelles

1st Edition
May 23, 2025
Katherine Brehme Warren
English
eBook
9 7 8 1 4 8 3 2 8 2 0 3 9

Formation and Fate of Cell Organelles is a collection of papers that discusses the manner in which cellular structures arise from the component molecules, particularly on cytoplasmic inheritance, and the problem of spontaneous assembly. One paper describes the process how the phospholipid lecithin, assemble spontaneously into complex structures with great versatility when the lipid molecules are dispersed in an aqueous environment in vitro. Another paper discusses the resolution of the spindle fibers of the mitotic apparatus where the major protein in the apparatus is a 3.5 S particle, with a molecular weight of ca. 68,000. One paper investigates the degree of organization in the bacterial cell where inside the bacterial cell, the DNA act as its own method of compartmentation. Possibly, the DNA forms a coil which contains the mechanisms for the synthesis of the deoxy triphosphate into DNA. The coil leaves none of the mechanisms for the normal metabolism of the cell nor the mechanisms for the formation of RNA. Another paper examines cytoplasmic genes and organelle formation. The collection can prove valuable for bio-chemists, cellular biologists, micro-biologists, and developmental biologists.

Molecular Medicine and Biomedical Research in the Era of Precision Medicine

1st Edition
May 15, 2025
Ranbir Chander Sobti + 4 more
English
Paperback
9 7 8 0 4 4 3 2 2 3 0 0 6
eBook
9 7 8 0 4 4 3 2 2 3 0 1 3

Molecular Medicine and Biomedical Research in the Era of Precision Medicine: New Technologies and Personalized Drug Therapies for Patient Care provides researchers with an extensive overview of recent advances in molecular biology impacting the development of targeted therapies. The book delivers insights into the pathobiological and pathogenetic mechanisms of various diseases, providing a detailed study of the latest personalized interventions to be implemented across such conditions. It covers a range of technologies, including RNA-sequencing, AI, Machine Learning, gene therapy, omics and nanotechnology, delving into their clinical applications across various diseases.The book also tackles targeted treatments of different disease types, including acute, chronic, infectious and noncommunicable diseases. Future perspectives are also covered, providing an in-depth study across molecular medicine, drug discovery and delivery, disease diagnosis and prevention, and therapeutic interventions, and acting as an invaluable interdisciplinary reference for researchers across the biomedical sciences.

Handbook of Translational Transcriptomics

1st Edition
May 2, 2025
Anton Buzdin
English
Paperback
9 7 8 0 4 4 3 1 9 1 1 0 7
eBook
9 7 8 0 4 4 3 2 3 7 6 8 3

Handbook of Translational Transcriptomics: Research, Protocols and Applications provides a comprehensive overview of the field of transcriptomics. With an emphasis on the various protocols and techniques available for investigation, it acts as a practical guide to researchers for implementing their own investigations in the field.This book begins with an overview of the past, present, and potential approaches in the field of transcriptomics, with discussions of choosing the correct approach based on the research needed. It also highlights the pros and cons of each approach. Following this, it explores techniques and protocols for investigating specific approaches focusing on RNA sequencing, expression arrays, and gene expression. It then delves into data analysis and offers recommendations, guidelines, and approaches related to data interpretation. This book also considers the translation of transcriptomics to clinical use and applications in molecular diagnostics, biomarkers in medicine, and personalized medicine specific to oncology, as well as biotechnology for pharmaceutical research.Handbook of Translational Transcriptomics: Research, Protocols and Applications is a detailed reference that provides a complete view of transcriptomics, ranging from methods to handling data and medical applications. This book is an invaluable guide for researchers working across molecular biology, genetics, bioinformatics and related fields, as well as graduate and PhD students in these areas.

Circulating Tumor Cells, From Biotech Innovation to Clinical Utility Part B

1st Edition
Volume 392
April 28, 2025
Carolina Reduzzi + 2 more
English
Hardback
9 7 8 0 4 4 3 1 3 6 5 5 9
eBook
9 7 8 0 4 4 3 1 3 6 5 6 6

Circulating Tumor Cells, From Biotech Innovation to Clinical Utility Part B, Volume 392 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Circulating Tumor Cells in Lung Cancer: integrating stemness and heterogeneity to improve clinical utility, Multi-omic Features and Clustering Phenotypes of Circulating Tumor Cells Associated with Metastasis and Clinical Outcomes, CTCs in CRC: updates, Proteomics and post-translational modification analysis in CTCs, Latest advances of CTC studies in prostate cancer, and Epigenetics and CTCs: new biomarkers and impact on tumor biology.

The Origins of Life

1st Edition
April 25, 2025
Karl Niklas + 2 more
English
Paperback
9 7 8 0 4 4 3 3 3 5 4 4 0
eBook
9 7 8 0 4 4 3 3 3 5 4 5 7

The Origins of Life: From Abiotic Chemistry to the First Cells is an essential textbook that tackles one of the greatest mysteries in science, how inanimate matter evolved into the first living things. The book takes an interdisciplinary approach, delving into the basic principles of the earth’s chemistry, the formation of pre-cellular entities, and the acquisition of chemical complexity. It explains the creation of chromosomes, metabolic pathways, and the features of the earliest prokaryotes. Users will find a detailed exposition of the World RNA Hypothesis in an accessible and easy-to-read style which is comprehensible for both science and non-science majors.This textbook is a critical resource for upper-level undergraduate students in Cellular Biology, specifically those studying or researching evolution, cellular chemistry, and pre-biotic chemistry, as well as non-science majors in courses on the philosophy of science or related topics. It is also useful for professionals in biochemistry, evolutionary biology, and astrobiology who wish to understand the origins of life and first cells. Science communicators could use this interdisciplinary textbook for teaching and dissemination to broader audiences as well.

Flow Cytometry in Immuno-oncology

1st Edition
Volume 195
April 4, 2025
Marcello Pinti + 1 more
English
Hardback
9 7 8 0 3 2 3 8 9 8 8 3 6
eBook
9 7 8 0 3 2 3 8 9 8 8 4 3

Flow Cytometry in Immuno-oncology, Volume 173 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, Basic principles of Flow cytometry in immuno-oncology, Good practice and methods for flow cytometry in immuno-oncology, Automated flow cytometry in immuno-oncology, Flow cytometric analysis of Tregs in solid tumors, Multiparametric analysis of Tumor infiltrating lymphocytes in solid tumors, Analysis of tumor-infiltrating immune cells in intracranial glioblastoma, Assessing chromosomal abnormalities in leukemias by Imaging flow cytometry, Flow cytometric analysis of cellular alkaline phosphatase in acute myeloid leukemia, and much more.

Encyclopedia of Bioinformatics and Computational Biology

2nd Edition
March 22, 2025
Shoba Ranganathan + 2 more
English
eBook
9 7 8 0 3 2 3 9 5 5 0 3 4

Bioinformatics and Computational Biology (BCB) combine elements of computer science, information technology, mathematics, statistics, and biotechnology, providing the methodology and in silico solutions to mine biological data and processes, for knowledge discovery.In the era of molecular diagnostics, targeted drug design, translational medicine and Big Data for personalized medicine, computational methods for data analysis are essential tools for biochemistry, biology, biotechnology, pharmacology, biomedical and computer science, as well as mathematics and statistics. New areas are emerging, and relatively isolated fields are becoming current hot research areas in BCB, such as Artificial Intelligence, Quantitative Biology, Computational Vaccinology, Epidemiology and Infection Diffusion, Synthetic Biology, and Phenomics. The role of BCB in characterizing SARS-CoV-2 variants and facing the COVID-19 pandemic is just one example of how these tools can help us better prepare for such future events.This Encyclopedia comprises three sections, covering Methods, Topics, and Applications. The methodologies and algorithms underpinning BCB are described in the Methods section; Topics covers traditional areas such as phylogeny, as well as more recent areas such as translational bioinformatics, cheminformatics and environmental informatics; Applications provides guidance for commonly asked “how to” questions.Navigating the maze of confusing jargon and the plethora of software tools is often confronting for students and researchers alike. This comprehensive and unique resource provides up-to-date theory and application content to address molecular data analysis requirements, with precise definitions of terminology and lucid explanations by field experts.

Multi-Omics Technology in Human Health and Diseases

1st Edition
March 17, 2025
Muzafar A Macha + 2 more
English
Paperback
9 7 8 0 4 4 3 1 3 5 9 5 8
eBook
9 7 8 0 4 4 3 1 3 5 9 6 5

Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omic offers an advanced exploration into the comprehensive understanding of disease etiology and prognosis through multiomics approaches. This authoritative volume delves into the applications of multiomics technology in elucidating complex human health conditions and diseases. It introduces the technology's potential for biomarker identification, drug discovery, and disease prognostication. For a thorough understanding of human health and diseases, particularly cancer, it is essential to integrate knowledge of molecular biomarkers across multiple omics levels, including the genome, epigenome, transcriptome, proteome, and metabolome. This resource addresses the current gaps in knowledge among students and researchers, providing in-depth coverage of multiomics technology and its implementation in scientific research and discovery.Multi-Omic... Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omics is a pioneering resource that presents cutting-edge information on contemporary multiomics technologies for big data interpretation and their applications in deciphering complex human pathobiology. This comprehensive guide is indispensable for researchers, academics, students, and industry professionals alike.

Protein Misfolding in Neurodegenerative Diseases

1st Edition
March 17, 2025
Neha Gogia + 2 more
English
Paperback
9 7 8 0 4 4 3 1 8 7 1 6 2
eBook
9 7 8 0 4 4 3 1 8 7 1 7 9

Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.

Methods for Monitoring Mitochondrial Functions During Pathogen Infection

1st Edition
Volume 194
March 10, 2025
Saverio Marchi + 1 more
English
Hardback
9 7 8 0 3 2 3 9 9 2 1 9 0
eBook
9 7 8 0 3 2 3 9 9 2 2 0 6

Methods for Monitoring Mitochondrial Functions During Pathogen Infection, Volume 194 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Mitochondrial Labeling with Fluorescent Proteins for Enhanced Morphological Characterization and Visualization of Intercellular Mitochondrial Transfer, Visualizing mitochondrial electron transport chain complexes and super-complexes during infection of human macrophages with Legionella pneumophila, Quantitative assessment of mitochondrial membrane potential in macrophages in sepsis, Quantification of mitochondrial reactive oxygen species in macrophages during sepsis, and much more.Additional chapters cover Quantification of intracellular and mitochondrial ATP content in macrophages during lipopolysaccharide-i... inflammatory response, Analysis of cytosolic mtDNA release during Staphylococcus Aureus infection, Monitoring mitochondria dynamics upon infection using a tomographic approach, A screening system to determine bacterial effects on MADCAM1 expression by high endothelial venule cells, Isolation of mitochondria from Mycobacteria infected cells, Monitoring mitochondrial localization of Mycobacterial proteins, and more.

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