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Elsevier

Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Fluorine Metabolism, Transport and Enzymatic Chemistry

    • 1st Edition
    • Volume 696
    • English
    Fluorine Metabolism, Transport and Enzymatic Chemistry, Volume 696 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting topics on Fluorine Metabolism, Transport, and Enzymatic Chemistry. Chapters in this new release include Determination of fluoride sensitivity and resistance in oral biofilm models, NMR methods to detect fluoride binding and transport by membrane proteins, Biotransformation of fluorinated drugs and xenobiotics by the model fungus Cunninghamella elegans, Measurement of fluoride efflux from lipid vesicles and cells, Defluorination of PFAS by Acidimicrobium sp. A6 and Potential Applications for Remediation, and more.Additional chapters cover Computational approaches to investigate F- binding, selectivity and transport in F- exporters, Defluorination as a key trait to gauge the biodegradability of fluorinated pollutants: challenges and opportunities, Patch-Clamp Electrophysiology of Fluoride Channels in Saccharomyces cerevisiae, and Synthesis of fluorophenylalanine-... proteins in HEK cells.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 126
    • English
    Advances in Applied Microbiology, Volume 126 continues the comprehensive reach of this widely read and authoritative review source in microbiology where users will find invaluable references and information on a variety of areas relating to the topics of microbiology.

  • Overview of Inflammatory Breast Cancer: Updates

    • 1st Edition
    • Volume 384
    • English
    International Review of Cell and Molecular Biology, Volume 381 highlights new advances in the field, with this new volume presenting interesting topic on Overview of Inflammatory Breast Cancer: Updates.

  • Exosomal RNA

    Role in Human Diseases and Therapy
    • 1st Edition
    • Debalina Bhattacharya + 2 more
    • English
    Exosomal RNA: Role in Human Diseases and Therapy provides an in-depth study of exosomes and their RNA in the context of a variety of diseases. The book explores the diagnostic and therapeutic potential of exosomal RNA as biomarkers across a range of different conditions, including cancer, type 2 diabetes, cardiovascular and renal disease, as well as bacterial infections and tissue repair. The link between exosomal RNA expression and neurodegenerative disease is also explored. The book goes on to share the significance of exosomal RNA in preserving cellular function, with special attention given to their role in the autophagy process.This book also gives an overview of the isolation, characterization, and potential applications of exosomal RNA, providing researchers with an understanding of how they can be manipulated and utilized for the treatment of various diseases and conditions. This is an ideal reference for researchers in the field of molecular biology, cell biology, and related fields, as well as those involved in the development of therapeutics and personalized medicine.

  • Animal Models of Disease Part A

    • 1st Edition
    • Volume 185
    • English
    Animal Models of Disease, Part A, Volume 185 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including New mouse model to study aneurysm development, Mouse Model of Secondary Cystic Echinococcosis, Modelling childhood cancer in Drosophila, Analysis of immunohistomorpholog... changes in the colonic mucosa in a high-saturated fat and high-cholesterol fed streptozotocin/nicot... diabetic rat model, Establishment of an orthotopic Glioblastoma mouse model for preclinical studies, Lateral Fluid Percussion Injury as a Model for Traumatic Brain Injury, Ovarian and colorectal peritoneal carcinomatosis in mouse models, and more.Other chapters cover Genetically engineered mouse model of hepatocellular carcinoma, Radiotherapy protocol in cancer mouse models, Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluation, Methodology for the induction of myocardial infarction and cardiac function evaluation, Behavioral assessment of fine socio-sexual olfactory cues detection in a mouse model of neurodegeneration, Heat shock and thermotolerance in Caenorhabditis elegans: an overview of laboratory techniques, and Using the model cestode Taenia crassiceps for the study of cysticercosis.

  • Heart Development and Disease

    • 1st Edition
    • Volume 156
    • English
    Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis, PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population.

  • Microbial Diversity in the Genomic Era

    Functional Diversity and Community Analysis
    • 2nd Edition
    • Surajit Das + 1 more
    • English
    Microbial Diversity in the Genomic Era: Functional Diversity and Community Analysis, Second Edition presents techniques used for microbial taxonomy and phylogeny, along with their applications and respective strengths and challenges. The book incorporates recently developed biosystematics methods and approaches to assess microbial taxonomy, with suitable recommendations for where to apply them across the range of bacterial identification and infectious disease research. Sections provide a broad overview of microbial genomics research and microbiome directed medicine and update on molecular tools for microbial diversity research, extremophilic microbial diversity, functional microbial diversity across application areas, microbial diversity and infectious disease research, and future directions. Step-by-step methodologies are provided for key techniques, along with applied case studies that break down recent research studies into practical components, thus illuminating pathways for new studies across the field.

  • Computational Intelligence in Protein-Ligand Interaction Analysis

    • 1st Edition
    • Bing Wang + 2 more
    • English
    Computational Intelligence in Protein-Ligand Interaction Analysis presents computational techniques for predicting protein-ligand interactions, recognizing protein interaction sites, and identifying protein drug targets. The book emphasizes novel approaches to protein-ligand interactions, including machine learning and deep learning, presenting a state-of-the-art suite of skills for researchers. The volume represents a resource for scientists, detailing the fundamentals of computational methods, showing how to use computational algorithms to study protein interaction data, and giving scientific explanations for biological data through computational intelligence. Fourteen chapters offer a comprehensive guide to protein interaction data and computational intelligence methods for protein-ligand interactions.

  • Functionalized Nanomaterials for Cancer Research

    Applications in Treatments, Tools and Devices
    • 1st Edition
    • Hamed Barabadi + 2 more
    • English
    Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step-by-step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients’ overall outcomes. The book discusses functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The book's chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. This is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment.

  • Open Electronic Data Capture Tools for Medical and Biomedical Research and Medical Allied Professionals

    • 1st Edition
    • Ashish Pundhir + 2 more
    • English
    Open Electronic Data Capture Tools for Medical and Biomedical Research and Medical Allied Professionals explains the step-by-step of collecting and treating research data in a didactic manner. The book discusses four freely available data capture tools whose common feature is data collection and entry being done simultaneously rather than separately, thus saving resources and minimizing potential errors. It highlights the comparative features of each data capture tool, helping readers to understand the advantage and disadvantage of each one to decide which tool can be used to fulfill their needs.This is a valuable resource for researchers, students, and members of the biomedical and medical fields who need to learn more about data mining and management to improve the quality of their research work.

  • Myeloid-Derived Suppressor Cells

    • 1st Edition
    • Volume 184
    • English
    Myeloid-Derived Suppressor Cells, Volume 184 in the Methods in Cell Biology series includes comprehensive protocols to assess the role of myeloid-derived suppressor cells (MDSCs), an immature, heterogenous cell population from the myeloid lineage with a potent immunosuppressive activity in a variety of diseases. This volume includes interesting protocols that address the Detection of myeloid-derived suppressor cells by flow cytometry, Determination of murine myeloid-derived suppressor cells by flow cytometry, Isolation of Myeloid-Derived Suppressor Cells (MDSC) from Endometriotic Mice Model and their Immunomodulatory Functions, Simple protocol for measuring CD11b+ GR-1+ (Ly6C+/Ly6G+) myeloid cells from a minimum volume of mouse peripheral blood, and much more.Additional chapters cover Assessment of myeloid-derived suppressor cell differentiation ex vivo, Single clonal tracking on biomimetic microtextured platforms for real-time guided migration analysis of myeloid-derived suppressor cell dissemination characteristics ex vivo, Isolation and immunosuppressive functions of myeloid-derived suppressor cell-derived exosomes, Characterization of lysosomal acid lipase in Ly6G+ and CD11c+ myeloid-derived suppressor cells, In Vitro Osteoclastogenesis Assessment using Murine Myeloid-derived Suppressor Cells, Estimating Nitric Oxide (NO) from MDSCs by Griess Method, and In vitro generation of myeloid-derived suppressor cells (MDSCs) from hematopoietic progenitor cells (HPCs).

  • Magnetic Tweezers for the Study of Protein Structure and Function

    • 1st Edition
    • Volume 694
    • English
    Magnetic Tweezers for the Study of Protein Structure and Function, Volume 694 in the Methods in Enzymology serial highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Single membrane protein tethering for magnetic tweezer experiments, Membrane protein folding studies using a robust magnetic tweezer method, Magnetic tweezers in cell mechanics, and more.

  • Microbes at Bio/Nano Interfaces

    • 1st Edition
    • Volume 54
    • English
    Microbes at Bio/Nano Interfaces, Volume 54 in the Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Advanced Hydrogel for Management of Bacterial Wound Infections, Biofilm Characterization: Imaging, analysis and considerations, Parasitic worm interactions with host molecular machinery, Investigation of microbes and surface carbohydrates using Atomic Force Microscopy, Interactions Between Microbial Cells and Titanium Implant Surfaces, Targeting Bacterial Polysaccharides with Antibodies and Vaccines, and much more.Other sections cover Using next generation sequencing to study host-pathogen interactions, Microbial Nano-Biosynthesis: Biomedical, Food and Environmental Applications, and Functional co-expression of LEA peptides: Providing an environment for efficient cellular recombinant protein expression.

  • Artificial Intelligence in Medicine

    From Ethical, Social, and Legal Perspectives
    • 1st Edition
    • Joseph JY Sung + 1 more
    • English
    Artificial Intelligence in Medicine: From Ethical, Social, and Legal Perspectives provides answers on how to improve acceptance and diminish the anxiety of the use of AI-assisted medicine. Through a series of social, ethical, and legal discussions from clinicians, social scientists, ethicists, and legal experts, this important reference has coverage that includes good data custodianship and stewardship, data access, data bias, data & healthcare equity, privacy and confidentiality, algorithmic understanding, and regulatory guidance, accountability, and legal responsibility.This reference will explain to healthcare providers how AI will enhance healthcare, will introduce to scientists and researchers the ethical and social aspect of AI that needs to be addressed, and will urge policymakers and health authorities to consider the legal framework needed to implement AI technology in healthcare.

  • Applications of Artificial Intelligence in Healthcare and Biomedicine

    • 1st Edition
    • Abdulhamit Subasi
    • English
    Applications of Artificial Intelligence in Healthcare and Biomedicine provides ​updated knowledge on the applications of artificial intelligence in medical image analysis. In 16 chapters, it presents artificial applications in Electrocardiogram (ECG), Electroencephalogram (EEG) and Electromyography (EMG), signal analysis, Computed Tomography (CT), Magnetic Resonance Imaging (MR), and Ultrasound image analysis. It equips researchers with tools for early breast cancer detection from mammograms using artificial intelligence (AI), AI models to detect lung cancer using histopathological image, and a deep learning-based approach to get a proper and faster diagnosis of the Optical Coherence Tomography (OCT) images.In addition, it presents 3D medical image analysis using 3D Convolutional Neural Networks (CNNs). Final sections cover an AI-based approach to forecast diabetes patients' hospital re-admissions. This is a valuable resource for clinicians, researchers, and healthcare professionals who are interested in learning more about the applications of Artificial Intelligence and its impact in medical/biomedical image analysis.

  • RNA Therapeutics Part B

    • 1st Edition
    • Volume 204
    • English
    RNA Therapeutics, Part B, Volume 204 updates on a new class of medication based on RNA molecules, with chapters on a variety of topics, including RNA therapeutics for cardiovascular disorders, RNA therapeutics for kidney injury, RNA therapeutics for beta-thalassemia, RNA therapeutics for infectious diseases, RNA therapeutics for reproductive diseases, Potential of RNA and transcriptomic data to drive drug repurposing for various diseases, RNA therapeutics for glioma/glioblastoma, RNA therapeutics for regenerative medicine, Advances in the liposome-based delivery systems for RNA therapeutics in cancer, Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics in cancer, and more.

  • Translational Bioinformatics

    • 1st Edition
    • Volume 139
    • English
    Translational Bioinformatics is an emerging field in the direction of biomedical research. High throughput technologies can be applied to the generated biological data to develop the vaccine and personalized medicine. This volume consists of the chapters from different stalwart of the field covering the topics such as drug development, vector engineering, vaccine development and translational genomics. Chapters covered in this volume discuss the translational research related with cancer, Alzheimer disease and cardiovascular diseases. This volume includes the chapter describing the importance of computational resources and chemoinformatics for the translational health research. How Omics studies are helping to translate the laboratory data into the development of tools which are beneficial in the clinics have been described. How translational bioinformatics helpful in plant genomics to improve the crops have also been included in this volume. This volume has a chapter which describes the secrets of resistance development and further how these resistance are associated with human infectious diseases. This volume will be useful to the early career researcher in the development of research idea and develop their methodologies in the direction of bioinformatics and it will also give the insight to translate their findings.

  • Chitosan-Based Hybrid Nanomaterials

    • 1st Edition
    • Nisar Ali + 3 more
    • English
    Chitosan-Based Hybrid Nanomaterials focuses on chitosan, an abundantly occurring biopolymer, to present possibilities for the removal of contaminants and a greener approach towards a cleaner environment – combining nanotechnology with the deployment of naturally occurring materials to remedy environmental challenges. This book fills research gaps and what is known about chitosan-based nanomaterials. Considering the importance of naturally occurring materials with the applied knowledge of nanotechnology in the field of environmental restoration, this book is an ideal resource for interested parties and career professionals.

  • Cell-based Cancer Immunotherapy

    • 1st Edition
    • Volume 183
    • English
    Cell-based Cancer Immunotherapy, Volume 183 provides the latest progress concerning research on anticancer cellular immunotherapies and their immunological, translation, or clinical aspects. Topics covered in this volume include Methods behind clinical DC vaccine products against glioblastoma, Fully closed and automated isolation of natural blood dendritic cells for cancer immunotherapy, Methods behind Oncolytic virus-based DC vaccines in cancer: towards a multiphase combined treatment strategy for Glioblastoma (GBM) patients, Identification of TCR repertoire patterns linked with anti-cancer immunotherapy, Training of epitope-TCR prediction models with healthy donor-derived cancer-specific T cells, Methods behind neoantigen predictions for anticancer vaccines, Methods behind CD137L-DC-EBV-VAX anticancer vaccine, and much more. Additional sections cover Gold Standard Assessment of Immunogenic Cell Death Induced by Photodynamic Therapy: From In Vitro to Tumor Mouse Models and Anti-Cancer Vaccination Strategies, Methods behind TCR analyses for colorectal cancer-associated TILs, The use of xCELLigence, Incucyte, and/or Cr/LDH/maker-release assays, Humanized mouse models for anti-cancer therapy, In vitro re-challenge of CAR T cells, Methods behind adoptively transferred tumor draining lymphocytes​ for anticancer immunotherapy, and A murine glioblastoma platform to test cellular therapies with the standard of care.

  • A Biologist’s Guide to Artificial Intelligence

    Building the foundations of Artificial Intelligence and Machine Learning for Achieving Advancements in Life Sciences
    • 1st Edition
    • Ambreen Hamadani + 3 more
    • English
    A Biologist’s Guide to Artificial Intelligence: Building the Foundations of Artificial Intelligence and Machine Learning for Achieving Advancements in Life Sciences provides an overview of the basics of Artificial Intelligence for life science biologists. In 14 chapters/sections, readers will find an introduction to Artificial Intelligence from a biologist’s perspective, including coverage of AI in precision medicine, disease detection, and drug development. The book also gives insights into the AI techniques used in biology and the applications of AI in food, and in environmental, evolutionary, agricultural, and bioinformatic sciences. Final chapters cover ethical issues surrounding AI and the impact of AI on the future.This book covers an interdisciplinary area and is therefore is an important subject matter resource and reference for researchers in biology and students pursuing their degrees in all areas of Life Sciences. It is also a useful title for the industry sector and computer scientists who would gain a better understanding of the needs and requirements of biological sciences and thus better tune the algorithms.

  • RNA Therapeutics Part A

    • 1st Edition
    • Volume 203
    • English
    RNA Therapeutics, Part A, Volume 203 presents the latest on a new class of medication based on RNA molecules. The book includes timely chapters that focus on An introduction to RNA therapeutics and potentials, The development and technologies of RNA therapeutics, Types of RNA therapeutics, Molecular mechanisms of RNA therapeutics, IT, and AI applications in RNA therapeutics, The application of data sciences and bioinformatics in RNA therapeutics, RNA therapeutics history and future perspectives, Recent applications of RNA therapeutic in clinics, Advantages and disadvantages of RNA therapeutics, RNA therapeutics for neurological disease, RNA therapeutics for metabolic disorders, and RNA therapeutics for metabolic disorders.

  • Proteomics Mass Spectrometry Methods

    Sample Preparation, Protein Digestion, and Research Protocols
    • 1st Edition
    • Paula Meleady
    • English
    Proteomics Mass Spectrometry Methods: Sample Preparation, Protein Digestion, and Research Protocols shares best practices collected across key laboratories and core facilities, taking the reader through key tactics for executing the most usual mass spectrometry experiments. Sections review research making use of MS proteomics experiments, focus on critical sample preparation, cover mammalian cell lines and samples from clinical tissue and biological fluids, discuss subcellular fractionation, provide methods for protein digestion both for in gel and in solution, and delve into key MS proteomics analysis protocols, including label-free LC-MS, TMT and iTRAQ labelled LC-MS, phosphorylation enrichment, ubiquination enrichment, and more. This book is the perfect lab manual for research teams or for use as a new staff training material. Core facility managers may also find it useful for sharing best practices with their staff and researchers.

  • Epigenetic Regulation of Cancer - Part B

    • 1st Edition
    • Volume 383
    • English
    Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer.

  • DNA Damage and Chromosomal Instability

    • 1st Edition
    • Volume 182
    • English
    DNA Damage and Chromosomal Instability, Volume 182 in the Methods in Cell Biology series, presents interesting chapters on a variety of timely topics, including Induction of chromosome-specific micronuclei and chromothripsis by centromere inactivation, Generation of aneuploid cells and assessment of their ability to survive in presence of chemotherapeutic agents, Genetic reporters to detect and quantify homologous recombination in yeast, Mapping histone variant genomic distribution: exploiting SNAP- Tag labelling to follow the dynamics of incorporation of H3 variants, Enrichment of DNA replication intermediates by EdU pull down, Nascent DNA sequencing and its diverse applications in genome integrity research, and much more. Additional chapters cover Enrichment of DNA replication intermediates by EdU pull down, DNA curtains for studying phase separation mechanisms of DNA-organizing proteins, Visualizing the Dynamics of DNA Replication and Repair at the Single-Molecule Molecule Level, Cloning and Expansion of Repetitive DNA Sequences, Using an ImageJ-based script to detect replication stress and associated cell cycle exit from G2 phase by fluorescence microscopy Arne Lindqvist

  • MicroRNA in Human Infectious Diseases

    • 1st Edition
    • Vijay Kumar Prajapati + 1 more
    • English
    MicroRNA in Human Infectious Diseases offers an overview of the therapeutic and diagnostic role microRNAs can play in treating infectious diseases. Beginning with an introduction on microRNAs and their mechanisms, the book then delves into the therapeutic role of microRNAs in various categories of diseases, including bacterial, viral, and parasitic. A wide range of diseases are explored, including STDs, typhoid, tuberculosis, Dengue fever, Ebola, Covid-19, Malaria, Leishmaniasis, and Lymphatic filariasis. The final section of the book covers microRNA-based system approaches, considering aspects such as web-based tools available for detecting and predicting microRNA targets and the latest technologies for modifying and manipulating microRNAs.This volume explores microRNA across a multitude of conditions and is an ideal reference for those involved in the investigation and development of treatments in this area.

  • Immunobiology of COVID-19

    • 1st Edition
    • Volume 202
    • English
    Immunobiology of COVID19, Volume 202 in the Progress in Molecular Biology and Translational Science Series provides a comprehensive and in-depth exploration of the SARS-CoV-2 virus and its impact on human health. Written by a team of expert contributors, the book covers various aspects of the virus, including its structure, lifecycle, and genomic replication. It delves into the epidemiology of COVID-19, comparing it with other related coronaviruses and discussing the concept of herd immunity. The structural biology of SARS-CoV-2 is examined, with a focus on techniques such as electron microscopy and cryo-electron tomography. The book also explores the biology of SARS-CoV-2 variants and their immune evasion strategies. Furthermore, it delves into the pathogenesis of COVID-19, examining its multiorgan manifestations and the long-term effects of the disease. The innate and adaptive immune responses to SARS-CoV-2 are discussed in detail, along with the role of B cells and T cells in the immune response. The volume concludes with a look at future insights and potential developments in the field. Accompanied by illustrative diagrams and visuals, this volume will serve as a valuable resource for researchers, healthcare professionals, and anyone interested in understanding the intricate details of SARS-CoV-2 and its impact on global health.

  • Immune Checkpoint Biology in Health and Disease

    • 1st Edition
    • Volume 382
    • English
    Immune Checkpoint Biology in Health and Disease, Volume 382 provides in-depth reviews on the latest progress concerning research on immune-checkpoint biology and its immunotherapeutic implications, especially in cancer. Topics connected to immune-checkpoint biology covered in this volume include Novel technologies for applying immune checkpoint blockers, Next-generation deconvolution of transcriptomic data to investigate the tumor microenvironment, Immune checkpoints targeting dendritic cells for antibody-based modulation in cancer, Immune checkpoint biology in health & disease: Immune checkpoint biology and autoimmunity in cancer patients, and much more.Other sections cover Recent advancements in tumor microenvironment landscaping for target selection and response prediction in immune checkpoint therapies achieved through spatial protein multiplexing analysis, Immune Modulation During Anti-Cancer Radio(immuno)therapy... and Preconditioning with immunogenic cell death-inducing treatments for subsequent immunotherapy.

  • Cellular Senescence and Aging

    • 1st Edition
    • Volume 181
    • English
    Cellular Senescence and Aging, Volume 181 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as assessing polyglutamine tract aggregation in the nematode Caenorhabditis elegans, Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino, Methods for detection of mitochondrial reactive oxygen species in senescent cells, Assessment of cell cycle progression and mitotic slippage by videomicroscopy, The original colorimetric method to detect cellular senescence, and more.Additional sections cover Assessing microbiota composition in the context of aging, Assessing chronological aging in Saccharomyces cerevisiae, Image processing and supervised machine learning for retinal microglia characterization in senescence, Measuring telomerase activity using TRAP assays, High throughput assessment of cellular senescence, Detection of radiation-induced senescence by the Debacq-Chainiaux protocol: Improvements and upgrade in the detection of positive events, Dynamic and scalable assessment of the senescence-associate... secretory phenotype (SASP), Flow cytometry-assisted quantification of cell cycle arrest in cancer cells treated with CDK4/6 inhibitors, and more.

  • Advances in Protein Chemistry and Structural Biology

    • 1st Edition
    • Volume 138
    • English
    Advances in Protein Chemistry and Structural Biology, Volume 138 covers reviews of methodology and research in all aspects of protein chemistry, including purification/express... proteomics, modeling and structural determination and design. Chapters in this release include Proteomic Applications in Identifying Protein-Protein Interactions, Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach, Proteomics provides insights into theranostic potential of extracellular vesicles, Towards a shareable functional analysis of the structural proteome, Functional unfoldomics, In-silico Network Pharmacology Study on Glycyrrhiza glabra: Analyzing the Immune-Boosting phytochemical properties of Siddha Medicinal Plant against COVID-19, and more.Other chapters cover In silico Network Pharmacology Analysis and Molecular Docking Validation of Swasa Kudori for Screening Druggable Phytoconstituents of Asthma, Proteomics and Genomics Insights on Malignant Osteosarcoma, Application of functional proteomics in understanding RNA Virus-Mediated Infection, Biofilm proteome of Staphylococcus aureus: implications for therapeutic interventions to biofilm-associated infections, A computational pipeline elucidating functions of conserved hypothetical Trypanosoma cruzi proteins based on public proteomic data, Functional Proteomics based on Protein Microarray Technology for Biomedical Research, and an Analysis of endoglucanases production using proteomics and metatranscriptomics.

  • Molecular Biology of B Cells

    • 3rd Edition
    • Tasuku Honjo + 4 more
    • English
    Molecular Biology of B Cells, Third Edition provides a comprehensive reference on how B cells are generated, selected, activated, and engaged in antibody production. These developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. The book offers an integrated view of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. This new edition provides updated research on B cell development and function, the use of therapeutic antibodies in cancer and infectious disease, and more. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, this updated release is a definitive resource, vital for researchers across molecular biology, immunology, and genetics.

  • Cilia Signaling in Development and Disease

    • 1st Edition
    • Volume 155
    • English
    Cilia Signaling in Development and Disease, Volume 155 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Cilia and mTOR signaling, Cilia and Kidney, Extraciliary functions of IFT proteins, Cilia and eye stem cells, Cilia and eye development, Cryo-EM/ET and cilia structure, and Control of protein and lipid composition of photoreceptor outer segments and the implications for eye diseases.

  • Artificial intelligence, Big data, blockchain and 5G for the digital transformation of the healthcare industry

    A movement Toward more resilient and inclusive societies
    • 1st Edition
    • Patricia Ordonez de Pablos + 1 more
    • English
    ​Artificial intelligence, Big data, Blockchain and 5G for Digital Transformation of Healthcare Industry: A Movement Towards More Resilient and Inclusive Societies delivers a collection of relevant innovative research on digital healthcare, with a three mains goals: 1) study the successes and failures in the field of IT and digital health during the pandemic, and analyze the lessons from these cases; 2) discuss the latest advances in the field of digital healthcare, with a special focus on Artificial Intelligence, Big Data, Blockchain and 5G; and 3) discuss implications for main stakeholders (patients, doctors, IT experts, directors, policy managers.The global outbreak caused by covid-19 caused global disruption in societies, healthcare systems, and economies around the world. This book provides insight to Researchers, clinicians, CEOs and policymakers who need to learn from the failures and successes and exploit the potential of advanced information technologies to build stronger healthcare systems, better quality healthcare services, and more resilient societies.

  • Rigor and Reproducibility in Genetics and Genomics

    Peer-reviewed, Published, Cited
    • 1st Edition
    • English
    Rigor and Reproducibility in Genetics and Genomics: Peer-reviewed, Published, Cited provides a full methodological and statistical overview for researchers, clinicians, students, and post-doctoral fellows conducting genetic and genomic research. Here, active geneticists, clinicians, and bioinformaticists offer practical solutions for a variety of challenges associated with several modern approaches in genetics and genomics, including genotyping, gene expression analysis, epigenetic analysis, GWAS, EWAS, genomic sequencing, and gene editing. Emphasis is placed on rigor and reproducibility throughout, with each section containing laboratory case-studies and classroom activities covering step-by-step protocols, best practices, and common pitfalls. Specific genetic and genomic technologies discussed include microarray analysis, DNA-seq, RNA-seq, Chip-Seq, methyl-seq, CRISPR gene editing, and CRISPR-based genetic analysis. Training exercises, supporting data, and in-depth discussions of rigor, reproducibility, and ethics in research together deliver a solid foundation in research standards for the next generation of genetic and genomic scientists.

  • Genomics in the Clinic

    A Practical Guide to Genetic Testing, Evaluation, and Counseling
    • 1st Edition
    • Antonie D. Kline + 1 more
    • English
    **Selected for 2025 Doody’s Core Titles® in Clinical Genetics**Genomics in the Clinic: A Practical Guide to Genetic Testing, Evaluation, and Counseling illustrates the current scope of the practice of genetics for healthcare professionals, so they can understand principles applicable to genetic testing and consultation. Written by an authoritative well-balanced team, including experienced clinical geneticists, genetic counselors, and medical subspecialists, this book adopts an accessible, easy-to-follow format. Sections are dedicated to basic genetic principles; clinical genetic and genomic testing; prenatal, clinical and cancer genetic diagnosis and counseling; and ethical and social implications in genomic medicine. Over 100 illustrative cases examine a range of prenatal, pediatric and adult genetic conditions and testing, putting these concepts and approaches into practice. Genomics in the Clinic: A Practical Guide to Genetic Testing, Evaluation, and Counseling is important for primary care providers, as patient care evolves in the current genomic-influenced world of precision medicine.

  • Enzymes in RNA Science and Biotechnology Part B

    • 1st Edition
    • Volume 692
    • English
    Enzymes in RNA Science and Biotechnology, Part B, Volume 692 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as Quantitative base-resolution sequencing technology for mapping pseudouridines in mammalian mRNA, Quantitative base-resolution DAMM-seq for mapping RNA methylations in tRNA and mitochondrial dsRNA, Discovering RNA modification enzymes using a comparative genomics approach, Functional analysis of tRNA modification enzymes using mutational profiling, and Fluorescent labeling of tRNA for rapid kinetic interaction studies with tRNA-binding proteins.Other chapters cover Enzymatic Synthesis of RNA Standards for Mapping and Quantifying RNA Modifications in Sequencing Analysis, Characterizing RNase L-mediated mRNA decay in single cells, Characterization of RNase J, Pri-miRNA cleavage assays for the Microprocessor complex, The pre-miRNA cleavage assays for DICE, Methods for study of ribonuclease targeting chimeras, and Profiling the in vivo RNA interactome associated with the endoribonuclease RNase III in Staphylococcus aureus.

  • Enzymes in RNA Science and Biotechnology

    • 1st Edition
    • Volume 691
    • English
    Enzymes in RNA Science and Biotechnology, Volume 691 in the Methods in Enzymology series, highlights new advances in the field, including chapters on Reverse transcriptase Part I (discovery, preparation, general utilization, MarathonRT for routine RT-PCR and for cDNA synthesis on challenging RNA templates Structured RNAs, repeat RNAs and more, Engineering TNA Polymerases Through Iterative Cycles of Directed Evolution, Reverse transcriptase Part II (RNA structure mapping and determination), RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays, tRNA Structure-seq in vivo and in droplets, Capture the in vivo intact RNA structurome by CAP-STRUCTURE-seq, and more.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 125
    • Geoffrey M. Gadd + 1 more
    • English
    Advances in Applied Microbiology, Volume 125 continues the comprehensive reach of this widely read and authoritative review source in microbiology where users will find invaluable references and information on a variety of areas relating to the topics of microbiology.

  • Radiation Oncology and Radiotherapy Part C

    • 1st Edition
    • Volume 180
    • English
    Radiation Oncology and Radiotherapy Part C, Volume 180 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Image-guided Radiation Therapy of tumors in preclinical models, Methods to preserve correct dosimetry in small animal irradiators, Monitoring TGFbeta signaling in irradiated tumors, Pipeline to characterize the TCR repertoire of irradiated tumors, Pipeline to identify tumor neoantigens exposed by radiation, Methods to assess abscopal responses in mice, Monitoring the biodistribution of radiolabeled therapeutics in mice, and more. Additional chapters cover Methods to assess radiation-induced fibrosis in mice, Methods to assess radiation-induced cardiotoxicity in mice, Histological assessment of intestinal injury by radiation, Methods to investigate CNS involvement in irradiated mice, Methods to characterize the exosomal output of irradiated cancer cells, and more.

  • Modern Methods of Drug Design and Development

    • 1st Edition
    • Volume 690
    • English
    Modern Methods of Drug Design and Development, a volume in the Methods in Enzymology series highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Recombinant protein purification for structural and kinetic studies, Steady-state kinetic analysis of reversible enzyme inhibitors, Steady-State Enzyme Kinetics, Analysis of enzyme kinetic data using ICEKAT, NMR techniques in drug discovery, Dynamic simulations and pre-steady state kinetics to guide drug discovery, Design and assay of substrate-product analogues for racemases and epimerases, Sensitive high throughput methods to screen for P450 inhibition: A- MI complex forming drugs, and more. Other chapters cover Sensitive high throughput methods to screen for P450 inhibition: B-Heme loss causing drugs, Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosis, Crystallographic fragment screening in academic cancer drug discovery, Fast fragment- and compound-screening pipeline at the Swiss Light Source, Chemical biology, enzymology and drug discovery, PROTACs, Proximity-Induced Pharmacology (PROTACs), and much more.

  • Epigenetics in Human Disease

    • 3rd Edition
    • Trygve O. Tollefsbol
    • English
    Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies.

  • Steroid Biochemistry

    • 1st Edition
    • Volume 689
    • English
    Steroid Biochemistry, Volume 688 in the Methods of Enzymology series, highlights new advances in the field, containing chapters on a variety of timely topics, including Cytochrome P450 Enzyme, Steroidogenic P450s (CYP11A1, 17A1, 21A2, 11B1, and 11B5), Steroid 17 alpha-hydroxylase/17... (Cytochrome P450 17A1), Enzymes of Estrogen Biosynthesis, Aromatase and Steroid Sulfatase, Estrogenic 17b-Hydroxysteroid Dehydrogenase, Hydroxysteroid Dehydrogenases (HSD), 3a-Hydroxyssteroid Dehydrogenase, Approaches to Measuring 3b-Hydroxysteroid Dehydrogenase Type 1, 3b-Hydroxysteroid Dehydrogenase Type 2, and much more.

  • Phage Therapy - Part B

    • 1st Edition
    • Volume 201
    • English
    Phage Therapy - Part B, Volume 201 covers bacteriophage and their isolation, screening, synthetic phage, diagnostics, directed evolution, host interaction, and more. The book's aim is to highlight a number of aspects of phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform research. Sections cover Phages for the treatment of Pseudomonas aeruginosa infection, Phage for the treatment of Vibrio cholerae infection, Phages for the treatment of Mycobacterium species, Phage therapy for gut microbiome, Phages as delivery vehicles, Phage display, Unlocking the potential of Phages: Innovative Approaches to harnessing Bacteriophages as Diagnostic Tools for Human Diseases, and more. Other sections explore Phage display and human disease detection, Bacteriophage as Cargo and its application in nanomedicine, Phage for drug delivery vehicles, Genome editing for phage design and uses for therapeutic applications, Phage for cancer therapy, and Phage for regenerative medicine and cosmetics.

  • Advances in Stem Cells and their Niches

    • 1st Edition
    • Volume 7
    • Susie Nilsson
    • English
    Advances in Stem Cells and their Niches, Volume Seven highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Chromatin Readers in Health and Disease

    • 1st Edition
    • Volume 35
    • Olivier Binda
    • English
    Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders.

  • Circulating Tumor Cells, From Biotech Innovation to Clinical Utility Part A

    • 1st Edition
    • Volume 381
    • English
    "Circulating Tumor Cells, from biotech innovation to clinical utility" provides an overview of the most recent technological and clinical advances with regards to the study of circulating tumor cells (CTCs) in solid tumors. The volumes cover studies on CTCs in breast, prostate, colorectal and lung cancer, with a focus on clinical utility, and also include methodological and biological topics such as CTC culture, multi-omic characterization of CTCs, atypical CTC populations and interaction between CTCs and immunity.

  • Phage Therapy - Part A

    • 1st Edition
    • Volume 200
    • English
    Phage Therapy - Part A, Volume 200 is an informative text on phage and their use for treatment in bacterial infections. The book highlights a number of aspects of the phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform their research with great interest. Chapters in this new release cover An introduction to bacteriophage and their therapeutic applications, Isolation, screening and characterization of phage, Synthetic phage and their application in phage therapy, Phage engineering for development of diagnostic tools, Phage design and directed evolution to evolve phage for therapy, and more. Additional sections cover Host-phage interactions and modelling for therapy, Phage and phage cocktails formulations, Phage for treatment of Escherichia coli infection, Phage for treatment of Klebsiella pneumoniae infection, Phage for treatment of Salmonella spp infection, Phage for treatment of Staphylococcus aureus infection, and Phages for treatment of Acinetobacter baumannii infection.

  • Artificial Intelligence in Clinical Practice

    How AI Technologies Impact Medical Research and Clinics
    • 1st Edition
    • Chayakrit Krittanawong
    • English
    Artificial Intelligence in Clinical Practice: How AI Technologies Impact Medical Research and Clinics compiles current research on Artificial Intelligence within medical subspecialties, helping practitioners with diagnosis, clinical decision-making, disease prediction, prevention, and the facilitation of precision medicine. The book defines the basic concepts of big data and AI in medicine and highlights current applications, challenges, ethical issues, and biases. Each chapter discusses AI applied to a specific medical subspecialty, including primary care, preventive medicine, general internal medicine, radiology, pathology, infectious disease, gastroenterology, cardiology, hematology, oncology, dermatology, ophthalmology, mental health, neurology, pulmonary, critical care, rheumatology, surgery, and OB-GYN. This is a valuable resource for clinicians, students, researchers and members of medical and biomedical fields who are interested in learning more about artificial intelligence technologies and their applications in medicine.

  • Resident Stem Cells and Regenerative Therapy

    Sources and Clinical Applications
    • 2nd Edition
    • Regina Coeli dos Santos Goldenberg + 1 more
    • English
    Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

  • Active Learning for Digital Transformation in Healthcare Education, Training and Research

    • 1st Edition
    • Miltiadis D. Lytras + 1 more
    • English
    Active Learning for Digital Transformation in Healthcare Education, Training and Research discusses the potential of advanced training of health professionals as a contributing factor to improve treatment outcomes. By reading this book, professionals who deal with patients with low health literacy will be prepared to promote better access to digital tools, understand the habits of users of health services, and empower engagement. The book contains a set of techniques and instruments associated with health literacy, communication skills and personal development that will enable their application in good daily practices and assist healthcare professionals to promote digital transformation to patients. This is a valuable resource for researchers, graduate students and healthcare professionals who are interested in learning more about how they can be an effective agent of change in healthcare.

  • Our Genes, Our Choices

    How Genotype and Gene Interactions Affect Behavior
    • 2nd Edition
    • David Goldman
    • English
    Our Genes, Our Choices: How Genotype and Gene Interactions Affect Behavior, Second Edition explains how the complexity of human behavior, including concepts of free will, derives from a relatively small number of genes which direct neurodevelopmental sequences. Are people free to make choices or do genes determine behavior? Paradoxically, the answer to both questions is "yes," because of neurogenetic individuality, a new theory with profound implications. Here, author David Goldman uses judicial, political, medical, and ethical examples to illustrate that this lifelong process is guided by individual genotype, molecular and physiologic principles, as well as by randomness and environmental exposures.Written in an authoritative yet accessible style, the book includes practical descriptions of the function of DNA, discusses the scientific and historical bases of genethics, and introduces the topics of epigenetics and the predictive power of behavioral genetics.

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