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Elsevier

Books in Biochemistry biophysics

This portfolio spans the molecular mechanisms of life, encompassing protein structure, enzyme function, and biophysical techniques. It supports biochemists, biophysicists, and molecular biologists in understanding complex biological processes. Featuring advanced research, experimental methods, and real-world applications, these resources drive innovations in drug development, disease research, and biomolecular engineering, fostering breakthroughs at the intersection of chemistry, physics, and biology.

  • Profiles of Drug Substances, Excipients, and Related Methodology

    • 1st Edition
    • Volume 48
    • Abdulrahman Al-Majed
    • English
    Profiles of Drug Substances, Excipients, and Related Methodology, Volume 48 encompasses review articles and database compilations that fall within one or more of the following five broad categories: Physical Profiles of Drug Substances and Excipients; Analytical Profiles of Drug Substances and Excipients; ADME Profiles of Drug Substances and Excipients; Methodology Related to the Characterization of Drug Substances and Excipients; Methods of Chemical Synthesis. There is no comparable book series that gives this crucial information in such a timely and relevant manner. The volume offers in-depth profiles of Brimonidine, Cristine, Remdesivir, Vandetanib, and Lapatinib. It also includes an additional chapter on Pharmaceutical-Based Cosmetic Serums.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 82
    • English
    Advances in Microbial Physiology, Volume 82 in this serial that highlights new advances in the field, presents interesting chapters on a variety of topics, including Protein secretion via the Type I secretion system, Purine utilization by enterobacteria, Microbiology of Algae, Growth of enteric bacteria in the intestine on C4DCs: Governance of C4DC transporters in metabolic adaptation and genetic control, Biological functions of bacterial lysophospholipids, and much more.

  • Integrated Methods in Protein Biochemistry: Part C

    • 1st Edition
    • Volume 682
    • Arun K. Shukla
    • English
    Integrated Methods in Protein Biochemistry: Part C, Volume 679 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including NanoBiT-based methods to monitor the activation and modulation of RTKs, The interplay of G-protein βγ subunit and PLC-β enzyme in PIP2 hydrolysis and downstream signaling, Biochemical Analysis of Protein-Protein Interfaces underlying the regulation of Bacterial Secretion Systems, Probing the structure and function of N-acetylmannosamine-... 2-epimerase, Spectroscopic analysis of cysteine dioxygenase: a mammalian thiol-dioxygenase, DeGlyPHER: MS-based analysis of viral spike N-glycoforms, and more. Other sections cover Covalent protein painting: MS-based protein footprinting, Characterization of GPCR signaling complexes using negative-staining electron microscopy, Probing protein misfolding and dissociation with free electron laser, Optimized protocol for the characterization of Cas12a activities, Proximity proteomics for the identification and characterization of extracellular vesicles, Functional characterization of lytic polysaccharide monooxygenases (LPMOs), Characterization of RRE domain in RiPP biosynthesis, The Preparation of Recombinant Arginyltransferase 1 (ATE1) for Structural and Biophyiscal Characterizations, Testing anti-cancer drugs with Holographic Incoherent-light-sou... Quantitative Phase Imaging, and more.

  • Regulation of Downstream Targets

    • 1st Edition
    • Volume 134
    • Rossen Donev
    • English
    Regulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, presents interesting chapters on topics such as Transcriptional regulatory mechanisms and signaling networks in Viral Infections, Identification of potential key genes associated with pathogenesis and prognosis of endometrial cancer based on Integrated Bioinformatics Approaches, Differential regulation of genes in stage IB pancreatic cancer associated with increased risk of metastasis, AMPK-related LKB1-downstream targets, A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer, Protein phosphatases and their targets: Critical determinants of signaling pathway in plants, and more. Other sections cover Calcium decoders and their targets: The holy alliance that regulate cellular responses, Importin alpha family NAAT/IBB domain: functions of a multi-faceted long chameleon sequence, Aurora Kinase A and related downstream molecules: A Potential Network for Cancer Therapy, Emerging Role of Heat Shock Proteins in Cardiovascular Diseases, Function, Structure, Evolution, Regulation and Drug Target Relevance of Arylalkylamine N-acetyltransferase, and Analysis of signaling cascades from myeloma cells treated with pristimerin.

  • Hormones and Epigenetics

    • 1st Edition
    • Volume 122
    • Gerald Litwack
    • English
    Hormones and Epigenetics, Volume 122, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting timely, interesting chapters written by an international board of authors.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 113
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 113, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry with sections in this release focusing on Biosensors for saliva biomarkers, Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel, Protein Glycation in Diabetes Mellitus, Biomarkers of Oxidative Stress and Reproductive Complications, Cortisol: Analytical and Clinical Determinants, and Hemophilia A: Emicizumab monitoring and impact on coagulation testing.

  • Receptor Endocytosis and Signalling in Health and Disease - Part B

    • 1st Edition
    • Volume 196
    • English
    Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc. Chapters in this new release include Internalization of somatostatin receptors in brain and periphery, Mas receptor, signaling and trafficking in health and disease, Endocytosis of AMPA receptors: Role in neurological conditions, Endocytosis of dopamine receptor: Signaling in brain, and more. Additional chapters cover Endocytosis of LXRs: Signalling in liver, Endocytosis of LDL receptor: Importance in cardiovascular diseases, Advances in the molecular level understanding of G-protein-coupled receptor, Nuclear receptor: Structure and function, Integrin receptor trafficking in health and disease, B Cell Receptor (BCR) endocytosis,CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling, and much more.

  • Polysaccharide Degrading Biocatalysts

    • 1st Edition
    • Rosana Goldbeck + 1 more
    • English
    The transformation of polysaccharides into valuable compounds for health and industry requires the careful application of enzyme protocols and controlled biocatalysis. Polysaccharide-Degra... Biocatalysts provides a thorough grounding in these biocatalytic processes and their growing role in the depolymerization of polysaccharides, empowering researchers to discover and develop new enzyme-based approaches across pharmaceuticals, fuels, and food engineering. Here, over a dozen leading experts offer a close examination of structural polysaccharides, genetic modification of polysaccharides, polysaccharide degradation routes, pretreatments for enzymatic hydrolysis, hemicellulose-degrad... enzymes, biomass valorization processes, oligosaccharide production, and enzyme immobilization for the hydrolysis of polysaccharides, among other topics and related research protocols. A final chapter considers perspectives and challenges in an evolving, carbohydrate-based economy.

  • Atomic Force Microscopy for Nanoscale Biophysics

    From Single Molecules to Living Cells
    • 1st Edition
    • Mi Li
    • English
    Atomic Force Microscopy for Nanoscale Biophysics: From Single Molecules to Living Cells summarizes the applications of atomic force microscopy for the investigation of biomolecules and cells. The book discusses the methodology of AFM-based biomedical detection, diverse biological systems, and the combination of AFM with other complementary techniques. These state-of-the-art chapters empower researchers to address biological issues through the application of atomic force microscopy. Atomic force microscopy (AFM) is a unique, multifunctional tool for investigating the structures and properties of living biological systems under aqueous conditions with unprecedented spatiotemporal resolution.

  • Targeted Protein Degradation

    • 1st Edition
    • Volume 681
    • English
    Targeted Protein Degradation, Volume 680 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, with each. Each written by an international board of authors.

  • Basic Biotechniques for Bioprocess and Bioentrepreneurship

    • 1st Edition
    • Arvind Kumar Bhatt + 2 more
    • English
    Basic Biotechniques for Bioprocess and Bioentrepreneurship deals with the entire field of industrial biotechnology, starting from the basic laboratory techniques to scale-up, process development, demonstration, and finally its commercialization. The book compiles currently scattered materials on this topic and updates this information based on practical experience and requirements. The book will be an ideal source for new entrepreneurs who wish to start their own commercial units.

  • Biochemical Pathways and Environmental Responses in Plants: Part B

    • 1st Edition
    • Volume 680
    • English
    Biochemical Pathways and Environmental Responses in Plants, Part B, Volume 682 in the Methods in Enzymology series, highlights advances in the field with this new volume presenting chapters on MIE 681/682: Biochemical pathways and environmental responses in plants, Structure, function, and engineering of plant polyketide synthases, A sensitive LC-MS/MS assay for enzymatic characterization of methylthioalkylmalat... synthase involved in glucosinolate side-chain elongation, Assaying formate-tetrahydrofo... ligase with monoglutamylated and polyglutamylated substrates using a fluorescence-HPLC based assay, An Approach to Nearest Neighbor Analysis of Pigmented Protein Complexes by Using Chemical Crosslinking in Combination with Mass Spectrometry, Biochemical characterization of plant aromatic aminotransferases, and much more. Other chapters focus on Functional Analysis of Phosphoethanolamine N-methyltransferase (PMT) in Plants and Parasites, A structure-guided computational screening approach for predicting plant enzyme-metabolite interactions, Plant metacaspase: an example of microcrystal structure determination and analysis, Biocatalytic system for comparative assessment of functional association of cytochrome P450 monooxygenases with their redox partners, Dirigent Protein Family Function and Structure, and more.

  • G Protein-Coupled Receptors - Part B

    • 1st Edition
    • Volume 195
    • English
    G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more.

  • Antioxidants

    • 1st Edition
    • Volume 121
    • Gerald Litwack
    • English
    Antioxidants, Volume 121 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Developments and Applications of Enzymes From Thermophilic Microorganisms

    • 1st Edition
    • Pratima Bajpai
    • English
    Developments and Applications of Enzymes from Thermophilic Microorganisms extensively presents the industrial application of thermophilic/hyperth... enzymes. The book brings thorough and in-depth coverage on the role of these enzymes in a broad range of industries, focusing on present scenarios of these enzymes in biofuel industries, including recent advancements. The use of thermophilic enzymes in 2G biorefineries may enable the whole production process to take place at high temperatures, allowing increased reaction rate and reduced costs. Researchers in biochemistry, microbiology, microbial technology, biotechnology, molecular biology and bioresource technology will benefit from the new insights given on potential applications of hyperthermophiles. Hyperthermophilic enzymes, many of which survive at temperatures at or above 100C, contain novel macromolecules and metabolic systems which represent a vast resource for fundamental molecular and physiological studies, and for potential exploitation in biotechnology.

  • Secretory Proteins

    • 1st Edition
    • Volume 133
    • Rossen Donev
    • English
    Secretory Proteins, Volume 133 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, including chapters on Proprotein Convertases regulate trafficking and maturation of key proteins within the secretory pathway, Secretory Proteins in Cancer Diagnosis, Senescent Cells and SASP in Cancer Microenvironment: new approaches in cancer therapy, Autophagy for secretory protein: Therapeutic targets in cancer, Secretory proteins and pathways of secretion of osteosarcoma, Monocyte secretory proteins as drug targets for arresting progression of atherosclerosis, The secretory phenotypes of envenomed cells: insights into venom cytotoxicity, Macromolecules for secretory pathway in SARS-CoV-2 infection, and much more. Other sections cover Exploring the role of secretory proteins in the human infectious diseases diagnosis and therapeutics, Secretory proteins in orchestration of microbial pathogenesis- the curious case of Staphylococcus aureus, Influence of pathological mutations in Aspartylglucosylamin... Deaspartylase causing Aspartylglucosaminur... an in silico approach, and Change in conformational dynamics of Lipase A secretory protein upon mutation causing Wolman disease.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 112
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 112 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Heterogeneity in Major Depressive Disorder: The need for Biomarker-based and Personalized Treatments, Advances in exosome analysis, Translational Proteomics and Phosphoproteomics: Tissue to Extracellular Vesicles, Immune Checkpoint Therapy, Tumor Immunology, and Biomarkers in Non-Small-Cell Lung Cancer, Advances in Congestive Heart Failure Biomarkers, Fluid biomarkers in Alzheimer’s disease, and more.

  • Scattering Methods in Structural Biology Part B

    • 1st Edition
    • Volume 678
    • English
    Scattering Methods in Structural Biology, Part B, Volume 676 in the Methods in Enzymology serial, highlights advances in the field, presenting chapters on Quality controls, Refining biomolecular structures and ensembles by SAXS-driven molecular dynamics simulations, Data analysis and modelling of small-angle scattering data with contrast variation, Observing protein degradation in solution by the PAN-20S proteasome complex: state-of-the-art and future perspectives of TR-SANS as a complementary tool to NMR, crystallography and Cryo-EM, Extracting structural insights from chemically-specific soft X-ray scattering, Reconstruction of 3D density of biological macromolecules from solution scattering, ATSAS- present state and new developments in computational methods, and much more. Additional chapters cover Modeling Structure and Dynamics of Protein Complexes with SAXS Profiles (FoXSDock and MultiFoXS), Validation of macromolecular flexibility in solution by SAXS, Combining NMR, SAXS and SANS to characterize the structure and dynamics of protein complexes, Application of Molecular Simulation Methods to Analyze SAS Data, and more.

  • Receptor Endocytosis and Signalling in Health and Disease - Part A

    • 1st Edition
    • Volume 194
    • English
    Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more. Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications.

  • Biosurfactants

    Research and Development
    • 1st Edition
    • Gloria Soberon-Chavez
    • English
    Biosurfactants: Research and Development provides a thorough overview of biosurfactant research and development across a range of settings and industries, highlighting the novel use of enzymes, metabolic and genetic engineering in biosurfactant production and showcasing diverse experimental models and approaches. Sections discuss fundamental characteristics of biosurfactants, their physio-chemical properties, and their differences from chemically synthesize surfactants, different research approaches for the study of known biosurfactants, and the genetic manipulation of microorganisms to increase biosurfactant productivity, or to produce molecules with improved characteristics. Throughout the book, methods and approaches are discussed in easy-to-digest formats, with methods discussed, ranging from in silico approaches to classical biocatalysis omics analysis and metabolic engineering.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1st Edition
    • Volume 36
    • Aleš Iglič︎ + 2 more
    • English
    Advances in Biomembranes and Lipid Self-Assembly, Volume 36 serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Structure and Intrinsic Disorder in Enzymology

    • 1st Edition
    • Munishwar Nath Gupta + 1 more
    • English
    Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs.

  • DNA Damage and Double Strand Breaks Part B

    • 1st Edition
    • Volume 52
    • English
    Intersection of Iron and Lipid Metabolism, Volume 52 in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics relating to enzymes research.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 111
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 111, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists.

  • Small Angle Scattering Part A: Methods for Structural Investigation

    • 1st Edition
    • Volume 677
    • English
    Small Angle Scattering, Part A: Methods for Structural Investigation, Volume 675 in the Methods in Enzymology series, highlights new advances in the field, with new chapters in this updated release including SAXS foundations and metrics, Contrast variation sample preparation protocols, experimental procedures, and rudimentary analysis, Molecular deuteration for neutron scattering, Planning, Executing and Assessing the Feasibility of SANS Contrast Variation Experiments, Technical considerations for small-angle neutron scattering from biological macromolecules, and Advanced sample environments and capabilities at our synchrotron X-ray beamline with example applications. Additional sections in the book cover SEC-SAXS-MALS data acquisition and processing pipeline at SIBYLS, SEC-SAXS: pros and cons, experimental set-up, examples and software developments, Radiation damage and sample economy for stopped-flow methods in the time regime of millisecond and above, Stopped-flow-time-re... SAXS, Insights on Temp-jump, time-resolved SAXS, and much more.

  • Biocatalyst Immobilization

    Foundations and Applications
    • 1st Edition
    • Maria Lujan Ferreira
    • English
    Biocatalyst Immobilization: Foundations and Applications provides a comprehensive overview of biocatalytic immobilization processes, as well as methods for study, characterization and application. Early chapters discuss current progress in enzyme immobilization and methods for selecting and pretreating enzymes prior to immobilization, with an emphasis on navigating common challenges and employing enzyme supports and post immobilization treatments to impact enzymatic activity. Process-based chapters instruct on measuring and reporting on enzyme immobilization efficiency, protein final content, quantification of reaction products, and the use of nanomaterials to characterize immobilized enzymes. Later chapters examine recent advances, including novel enzymatic reactors, multi-enzymatic biocatalysts, enzymatic biosensors, whole cell immobilization, the industrial application of immobilized enzymes, and perspectives on future trends.

  • G Protein-Coupled Receptors - Part A

    • 1st Edition
    • Volume 193
    • English
    G Protein-Coupled Receptors, Part A, Volume 193 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field. G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins with an intricate involvement of nearly every physiological process in our body. Approximately, one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. These two volumes are focused on activation, signaling and regulation of GPCRs with specific examples of receptor systems and cellular processes.

  • Ion Transport and Membrane Interactions in Vascular Health and Disease

    • 1st Edition
    • Volume 90
    • English
    Ion Transport and Membrane Interactions in Vascular Health and Disease, Volume 90 in the Current Topics in Membranes series, highlights advances in the field, with this new volume including chapters on an Introduction to Ion transport and membrane interactions in vascular health and disease, Endothelial cell microdomains of Ca2+ and metabolism, Cytoplasmic nanojunctions between smooth muscle organelles control specific Ca2+ signaling, TRPML channels in coronary vascular phenotypic modulation and calcification, Local voltage-gated Ca2+ channel regulation of vascular smooth muscle in diabetes, Biphasic changes in smooth muscle Ca2+ transporters during the progression of coronary atherosclerosis, Role of K+ channels in atherosclerosis, and more.

  • Human Microbiome in Health and Disease - Part B

    • 1st Edition
    • Volume 192
    • English
    Human Microbiome in Health and Disease, Volume 192, Part B includes chapters surrounding the role of human microbiome in different diseases. Chapters in this comprehensive new volume include The microbiome and communicable diseases, Gut Microbiome and Antimicrobial Resistance in bacterial pathogens, Dysbiosis of human microbiome and infectious disease, Gastrointestinal microbiome in the context of infection in stomach and gastroduodenal diseases, Respiratory tract microbiome and pneumonia, Gut microbiome and neonatal sepsis, Diarrheal disease and gut microbiome, The microbiome and non-communicable diseases, Gut microbiome and inflammatory bowel disease, Gut microbiome and undernutrition, Human microbiome and cardiovascular disease, and much more.

  • Biochemical Pathways and Environmental Responses in Plants: Part A

    • 1st Edition
    • Volume 676
    • English
    Biochemical Pathways and Environmental Responses in Plants, Part A, Volume 676 in the Methods in Enzymology series highlights new advances in the field with this new volume presenting interesting chapters on topics such as Structure, function, and engineering of plant polyketide synthases, A sensitive LC-MS/MS assay for enzymatic characterization of methylthioalkylmalat... synthase involved in glucosinolate side-chain elongation, Assaying formate-tetrahydrofo... ligase with monoglutamylated and polyglutamylated substrates using a fluorescence-HPLC based assay, An Approach to Nearest Neighbor Analysis of Pigmented Protein Complexes by Using Chemical Crosslinking in Combination with Mass Spectrometry, and much more. Other chapters cover Biochemical characterization of plant aromatic aminotransferases, Functional Analysis of Phosphoethanolamine N-methyltransferase (PMT) in Plants and Parasites, A structure-guided computational screening approach for predicting plant enzyme-metabolite interactions, Plant metacaspase: an example of microcrystal structure determination and analysis, Biocatalytic system for comparative assessment of functional association of cytochrome P450 monooxygenases with their redox partners, Dirigent Protein Family Function and Structure, and more.

  • Integrated Methods in Protein Biochemistry: Part A

    • 1st Edition
    • Volume 675
    • English
    Integrated Methods in Protein Biochemistry: Part A, Volume 677, the latest release in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as DNA and protein engineering to create protein bioswitches with new functions, Interaction and cross-talk of prelamin A with integral membrane zinc metalloproteases, An experimental protocol to study lipid transfer proteins, Synthesis of small heat shock proteins, Druggable p-p interacting sites for Co-chaperone DNAJA1 and its partner proteins, An experimental protocol for glycoconjugate analysis, Methods for proximity-based biotinylation combined with Mass Spectrometry, and more. Additional chapters cover Synthetic antibody fragments as conformational sensors of protein activation and trafficking, Expression, purification, functional analysis and crystallization of Rag GTPase, Purification of bacterial transcription elongation complexes by photoreversible immobilization, Inhibition of c-Myc-MAX heterodimerization, Fluorogenic RNA aptamers to probe transcription by multi-subunit RNA polymerases, and much more.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 110
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 110, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists.

  • Role of TRPV4 Channels in Different Organ Systems

    • 1st Edition
    • Volume 89
    • English
    Role of TRPV4 Channels in Different Organ Systems, Volume 89, the latest release in the Current Topics in Membranes series, provides an in-depth description of the role of TRPV4 ion channels in different organ systems under healthy and disease conditions. Research over the last two decades shows crucial physiological and pathological roles for TRPV4 channels. In this volume, we present chapters focusing on TRPV4 channels in the vasculature, lungs, heart, kidney, bladder, skin, musculoskeletal system, eye, and immune cells. Understanding the behavior of TRPV4 channels in various organ systems will provide a big picture on their physiological roles and therapeutic targeting.

  • Human Microbiome in Health and Disease - Part A

    • 1st Edition
    • Volume 191
    • English
    Human Microbiome in Health and Disease, Volume 191, Part A presents updated knowledge on human microbiome as covered by renowned science faculty across the globe. Chapters in this volume include an introduction to human microbiome, Structure, functions and diversity of healthy human microbiome, Role of human microbiome in cancer, Gut microbiota and gastrointestinal cancer, Dysbiosis of human microbiome and metabolic diseases, Gut microbiome and type 2 diabetes, Gut microbiome and non-alcoholic fatty liver disease, Hepatic drug metabolism and intestinal microbiota, Emerging tools for understanding the human microbiome, and Microbiome therapeutics: Opportunity and challenges, and more. These chapters cover the composition, diversity, dynamics and functions of human microbiome in health and disease. This book will form an excellent and informative text on keystone, autochthonous, and exogenous microbiota important for human health in a simple to understand and easy to read format.

  • Peptide and Peptidomimetic Therapeutics

    From Bench to Bedside
    • 1st Edition
    • Nir Qvit + 1 more
    • English
    Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.

  • Basic Life Science Methods

    A Laboratory Manual for Students and Researchers
    • 1st Edition
    • Javeed Ahmad Tantray + 3 more
    • English
    Basic Life Science Methods: A Laboratory Manual for Students and Researchers presents forty of the most executed life science assays. The authors use a consistent structure to cover the preparation, execution and analysis of data from each method. Assays include estimation of cholesterol fractions, C-Reactive Protein, Genomic DNA isolation, Agarose Gel Electrophoresis, RT-PCR, DNA solution preparation, how to design primers, and enzyme-linked immunosorbent assay (ELISA). This book provides a complete reference containing step-by-step instructions on how to run life science assays. Laboratory staff can also benefit of the book as a training resource.

  • Quantum Mechanics, Cell-Cell Signaling, and Evolution

    • 1st Edition
    • John S. Torday
    • English
    Quantum Mechanics, Cell-Cell Signaling, and Evolution offers a detailed accounting of the latest research and theorizing on the integration of quantum physics with biological action to produce a novel perspective on evolution. The book advocates for a paradigm shift towards understanding biology and medicine causally as predictive sciences, presenting quantum mechanics and physiology as vertically integrated. The author has taken a unique approach to the question of how and why evolution occurred. The account is based on extensive knowledge of lipid physical chemistry, and its role in the evolution of the lung under the influence of hormonal effects on structure and function. The title arranges lipid biochemistry and biophysics into an integrated explanation, guiding readers from the immersion of lipids in water as the origin of life, to lung surfactant in alveolar homeostasis, and leading to a new understanding of how consciousness interacts with the laws of nature. This volume argues for a novel understanding of evolutionary processes based on fundamental science and positions itself as seeking consilience among research disciplines. Starting from the origins of the cosmos, the author proceeds through nucleosynthesis and Endosymbiosis Theory, to finally describe consciousness in relation to natural law.

  • A Mathematical Approach to Special Relativity

    • 1st Edition
    • Ahmad Shariati
    • English
    A Mathematical Approach to Special Relativity introduces the mathematical formalisms of special and general relativity. Developed from the author’s experience teaching physics to students across all levels, the valuable resource introduces key concepts, building in complexity and using increasingly advanced mathematical tools as it progresses. Without assuming a background in calculus, the text begins with symmetry, before delving more deeply into Galilean relativity. Throughout, the book provides examples and useful "Guides to the Literature." This unique text emphasizes the experimental consequences and verifications of the underpinning theory in order to provide students with a solid foundation in this key area.

  • Disorders of Protein Synthesis

    • 1st Edition
    • Volume 132
    • Rossen Donev
    • English
    Disorders of Protein Synthesis, Volume 132 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Precision Medicine

    • 1st Edition
    • Volume 190
    • David B. Teplow
    • English
    Precision Medicine, Volume 190 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Evolution of Biomarkers and Strategies for Integrating the Precision Philosophy to Guide Monitoring of Individualized Autoimmunity Conditions and to Implement the Philosophy into Clinical Practice, Precision Medicine in Epilepsy, The use of ASOs for personized medicine, Adult medicine, EGFR, NF-KB signal and regulatory noncoding RNAs in cancer, Precision medicine with multi-omics strategies, deep phenotyping, and predictive analysis, The Paradox of Personalized Medicine, and more.

  • Oral Delivery of Therapeutic Peptides and Proteins

    • 1st Edition
    • Puneet Tyagi + 1 more
    • English
    Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource.

  • Helicase Enzymes Part B

    • 1st Edition
    • English
    Methods in Enzymology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Parathyroid Hormone

    • 1st Edition
    • Volume 120
    • English
    Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 109
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 109, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Biomarkers of dysfunctional visceral fat, Immunoassay Design and Biotin Interference, Orexin/Hypocretin and Major Psychiatric Disorders and more.

  • Biocatalysis in Green Solvents

    • 1st Edition
    • Pedro Lozano
    • English
    Biocatalysis in Green Solvents offers a pragmatic overview and instruction in biocatalysis and enzymology of green solvents for sustainable industries and medicine, running from concept to application. Here, international experts in the field discuss structure-function relationships of enzymes in ionic liquids (ILs) and examine how enzymes act as selective catalysts for fine biochemical synthesis in non-aqueous environments. Several integral green biochemical processes of biocatalytic transformation and pure product separation are described in detail. Application focused chapters discuss the role of biocatalysis in creating and implementing deep eutectic solvents, biomass derived solvents, sub and supercritical fluids, carbon dioxide biphasic systems, and enzymatic membrane reactors, as well as applying these biocatalytic processes in drug discovery and production.

  • Essentials of Medical Biochemistry

    With Clinical Cases
    • 3rd Edition
    • Chung Eun Ha + 1 more
    • English
    Essentials of Medical Biochemistry, Third Edition offers a condensed, yet detailed overview of clinical biochemistry, spanning fundamentals and relevant physiologic and pathophysiologic concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis. Users will find fundamental concepts aiding students and professionals in biochemistry, medicine, and other healthcare disciplines. The text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists. This Third Edition has been fully updated to address evolving techniques in the biological sciences, including genomics, metabolomics, transcriptomics, epigenomics, proteomics, and gene therapy, among other methods. In addition, each chapter has been fully revised for current science and now features learning objectives and chapter summaries, supplemental reading, and 5 clinical case based multiple choice questions. New clinical cases have been added throughout.

  • Carotenoids: Carotenoid and Apocarotenoid Analysis

    • 1st Edition
    • English
    Carotenoids: Carotenoid and Apocarotenoid Analysis, Volume 670, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume covering Getting to know carotenoids, Laser capture of tissues for micro-scale carotenoid analyses, Metabolic engineering of carotenoids: procedures for metabolomic characterization, LC-MS analysis of intracellular metabolites for precursors to the carotenoid pathway, Use of E. coli to produce carotenoid standards, HPLC analysis of carotenoids from Bacteria, Purification and development of standards for carotenoid quantification in plant tissues, and much more. Additional sections in this release cover Ultra-High Performance Liquid Chromatography-Mass Spectrometry Analysis of Plant Apocarotenoids, Detection and analysis of novel and known volatile plant apocarotenoids, Carotenoid extraction, detection, and analysis in citrus, Strategies For The Separation And Tentative Identification Of Geometrical (Cis/Trans, Z/E) Isomers Of Carotenoids, Use of stable isotopes to study bioconversion and bioefficacy of pro-vitamin A carotenoids, Carotenoid extraction and analysis of blood plasma/serum, and more.</P>

  • Protein Interaction Networks

    • 1st Edition
    • Volume 131
    • Rossen Donev
    • English
    Protein Interaction Networks, Volume 131 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1st Edition
    • Volume 35
    • Aleš Iglič︎ + 2 more
    • English
    Advances in Biomembranes and Lipid Self-Assembly, Volume 35, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for the study of cell membranes, lipid model membranes and lipid self-assemblies, from the micro- to the nanoscale. As planar lipid bilayers are widely studied due to their ubiquity in nature, this book presents research on their application in the formulation of biomimetic model membranes, and in the design of artificial dispersion of liposomes. Chapters cover Physical properties of SOPC lipid membranes containing cholesterol by molecular dynamics simulation, Exciting membrane fluctuations - more than thermal stimulation, Fluctuations shaping bio-membrane adhesion, and more.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 108
    • Gregory S. Makowski
    • English
    Advances in Clinical Chemistry, Volume 108, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release focusing on Nephrinuria and podocytopathies, Extracellular vesicles in respiratory disease, Diabetes and cognitive decline, Testosterone analysis in prostate cancer, Mono/polyclonal free light chains as challenging biomarkers for immunological abnormalities, and more.

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