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Books in Biochemistry biophysics

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    • Lipids and Membranes: Metabolism, Lipidation, and Lipid-Protein Interactions

      • 1st Edition
      • Volume 728
      • English
      Lipids and Membranes: Metabolism, Lipidation, and Lipid-Protein Interactions, Volume 729 provides a broad snapshot of state-of-the-art methods for studying biological lipids and biomembranes. Sections in this new release cover De novo chemoenzymatic construction of lipid membranes, Photoaffinity labeling for cholesterol metabolism, Expression and Characterization of Phospholipase Cb and Ce enzymes, Assembling Retromer-coated membrane tubules for in vitro structure-function studies, Quantitative analysis of S-acylation, Inhibition of palmitoyltransferase... Exploiting protein lipidation to create peptide-based biomaterials, and much more.Additional sections discuss Optogenetic control of lipid-modifying enzyme activity using LOV domain insertions, Chemoproteomics approaches for inhibition of diacylglycerol kinases, Inhibition of sterol transfer protein function, Preparation of K-Ras4B containing synthetic modifications via expressed protein ligation, Regulation of lipin enzymes on membranes, Use of novel synthetic analogues to decipher the interactions of phosphatidic acids species, Analyzing lipid-nuclear receptor interactions, and much more.

    • Advances in Clinical Chemistry

      • 1st Edition
      • Volume 130
      • English
      Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. This volume provides invaluable information on the fast-moving field of chemistry research that includes outstanding original reviews on a variety of topics.

    • Design and Applications of Cell-Free Systems Part A

      • 1st Edition
      • Volume 218
      • English
      Design and applications of cell-free systems –Part A represents an important component in the field of biochemistry, duly acknowledging the pioneering effort made by Nobel laureate Eduard Buchner for discovery of fermentation in yeast cell extracts (YCE). CFS requires a core molecular machinery including RNA polymerase, translational apparatus (ribosomes, tRNA synthases, and translation factors), energy-generating molecules, and their cofactors, substrates, and DNA or plasmid templates for obtaining desired products. CFS is a simple, rapid, and sensitive platform, which is devoid of membrane-bound barriers, yet contains all the mandatory substrates, biomolecules, and machineries required for the synthesis of the desired proteins. It has the potential to overcome loopholes in the current in vivo production systems and it is promising tool in both basic and applied scientific research. It facilitates a simplified organization of desired experiments with a variety of reaction conditions, making CFS a powerful tool in biological and translational science research.This volume offers wide range of topics on different aspects of cell free systems design and their applications. It covers introduction to applications of cell-free systems, protocol for cell free design, transcription and translation, computational biology, artificial intelligence, automation and robotics for cell free systems, cell free for biosensor, low cost diagnostics, cell free based high throughput screening, biodesign and incorporation of non-natural amino acids into proteins. This volume helps students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand cell-free systems and their applications in many areas.

    • RNA Enzymology and Technology

      • 1st Edition
      • Volume 725
      • English
      RNA Enzymology and Technology, Volume 725 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as RNA enzymes in transcription, RNA processing, translation regulation, RNA transcriptase in gene expression regulation, Enzymes Involved in Ribosome Biogenesis and Translation Regulation, In Vitro Transcriptase: Methods for Studying RNA Synthesis, RNA Enzymes in RNA Silencing and Regulation, RNA Silencing Machinery: Mechanisms of RISC and MicroRNA Regulation, Enzymes in RNA-Based Therapeutics, and much more.Other chapters cover Antisense Oligonucleotides (ASOs) and RNase H: Mechanisms and Applications, RNA Enzymes in Targeted Therapeutics: From Bench to Bedside, Enzymes in RNA Sequencing and Analysis, Enzymes in High-Throughput RNA Sequencing: Applications and Challenges, Advanced Techniques and Future Directions, and much more.

    • Antimicrobial Peptides and Proteins

      • 1st Edition
      • Volume 149
      • English
      Antimicrobial Peptides and Proteins, Volume 149 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Nature and mechanistic action of Antimicrobial Peptides, Advances in elucidation molecular targets and mechanisms of action of AMPs: beyond membrane disruption, Discovery, Design, and Applications of Antimicrobial Peptides, Designing Potent Antimicrobial Peptides Against Acinetobacter baumannii: A Combined Approach Using Genetic Algorithms and Machine Learning Strategies, Protection of Diabetic Wound Patients from Invasive Bacterial Infections by Innate Antimicrobial Peptides, and more.Additional chapters explore Bacteriophage Lysins as a potential therapeutic strategy for Methicillin Resistant Staphylococcus aureus infections, Structural insights and therapeutic potential of host defense peptides in combatting antimicrobial resistance, Antimicrobial protein as a cargo for antimicrobial nanomaterials to combat Gram-negative bacteria, Unravelling the Role of Antimicrobial Proteins in Leptospirosis: A Comprehensive Transcriptomic Analysis, and Deciphering Antimicrobial Peptide (AMP) Resistance Mechanisms in Enterococcus faecalis Through Integrated RNA-Seq and Hub Genes Identification.

    • Microbial Enzymes

      Classification, Biochemistry, Production and Applications
      • 1st Edition
      • Abdel Moneim Elhadi Sulieman
      • English
      Microbial Enzymes: Classification, Biochemistry, Production and Applications explores the multifaceted roles of microbial enzymes, emphasizing their stability, ease of handling, and manipulation, all of which make them invaluable in various industrial processes. With 25 in-depth chapters, the book delves into the biochemistry of enzymes, their various sources, and their importance in biotechnology. It covers modern techniques for microbial enzyme detection and determination, methods of enzyme immobilization, and the application of microbial enzymes in industries such as food, medicine, pharmaceuticals, and textiles. Special sections discuss the biosynthesis of metal nanoparticles by microbial enzymes and the role of microbial toxins in different sectors. The book's chapters are organized in a way that provides detailed insights into the classification of enzymes, the mechanisms of microbial enzymes, and their industrial importance. Topics include bacterial, fungal, and algal enzymes, their applications, and the latest advancements in enzyme technology. Other sections address the challenge of antibiotic resistance and explores innovative methods for enzyme production and molecular engineering.

    • Protein Misfolding Diseases

      • 1st Edition
      • Volume 148
      • English
      Protein Misfolding Diseases, delves into the intricate molecular mechanisms behind a class of devastating disorders caused by abnormal protein folding. This comprehensive book explores interesting and updated topics, including Protein misfolding in hemophilia, Characterizing Protein Misfolding: Inside and Out, Heat Shock proteins (HSPs) as chaperones for Oncogenesis, Protein Misfolding and Cancer: Molecular Insights and Future Perspectives, Proteostasis and Pathogenesis: Unraveling the Complexity of Protein Misfolding Disorders, Small molecule inhibitors targeting α-synuclein aggregation: Progress and future outlook, and much more.Additional sections cover Chaperone Machinery in Neurodegeneration: A Spotlight on Protein Misfolding Diseases and Calpain- mediated proteolytic cleavage.

    • Recent Trends in Enzyme Immobilization

      • 1st Edition
      • Shailendra Kumar Arya + 3 more
      • English
      Recent Trends in Enzyme Immobilization explores the forefront of enzyme technology, providing a comprehensive guide on the latest methodologies and advancements. This book begins by setting the stage with foundational insights into enzyme immobilization, then progresses to discuss innovative techniques and their applications across various industries, including biopharmaceuticals, environmental science, and food processing. Structured to cater to both newcomers and seasoned professionals in biotechnology and biochemical engineering, each chapter delivers in-depth analysis and up-to-date research findings. Readers will find valuable resources in the practical guidance offered for optimizing enzyme stabilization, activity, and reusability in industrial applications. Moreover, the text addresses the theoretical underpinnings that frame current practices and illuminates future directions for research and technological advancements. Designed as an indispensable resource, this book aims to bridge the gap between academic research and practical application. It equips researchers, practitioners, and advanced students with the necessary tools and knowledge to drive innovation in enzyme immobilization, fostering the development of sustainable solutions and novel approaches in their work. With contributions from leading global experts, Recent Trends in Enzyme Immobilization serves as a critical reference that promises to inspire and guide readers through the complexities and potentials of this dynamic field.

    • Bacterial Efflux Systems

      • 1st Edition
      • Volume 724
      • English
      Bacterial Efflux Systems, Volume 722 covers experimental and computational approaches to study the function, structure, and mechanism of bacterial efflux pump systems. The methods covered include preparation of samples for structural and functional analyses and in vivo activity analysis. Specific chapters in this release cover Efflux pump functional assays, NMR and functional analysis efflux pumps, Methods for saturation mutagenesis and functional characterization, Cooperation and functional interplay between pumps, Mapping interactions, HDX-MS, and much more.Other sections cover Recombinant Expression and purification, Reconstitution of a RND efflux pump in different artificial membranes for a structural biology approach, Reconstitution of rnd and mfs efflux pumps for structural biology, CusCBA system, Expression and purification of efflux pumps of Gram positives, Expression and purification of efflux pumps of archaea, ABC transporters: BmrA preparation for NMR and PatA/PatB in peptidisc, In situ structural analysis of efflux assemblies by cryoET, Molecular dynamics simulations, and so much more.

    • Novel Bioproducts through Metabolic Engineering of Secondary Metabolites

      • 1st Edition
      • Yogesh K. Ahlawat + 3 more
      • English
      Novel Bioproducts through Metabolic Engineering of Secondary Metabolites provides comprehensive coverage of the latest developments in metabolic engineering and secondary metabolites, along with their roles in industrial product development. Sections cover the pivotal role secondary metabolites play in nature, their diverse classes, their significant applications in industry and medicine, and the fundamentals of metabolic engineering. Additional coverage includes biosynthetic pathways of secondary metabolites, strain development and optimization, rational design of pathway modifications, industrial enzymes and chemicals from metabolic engineering, and cutting-edge tools and technologies in metabolic engineering. The book concludes with a roadmap for the future of metabolic engineering, exploring emerging trends such as CRISPR and genome editing, artificial intelligence applications, and the evolving landscape of synthetic biology and bioeconomy.

Related subjects

Bioenergetics

Biological transport

Biomembranes

Carbohydrate biochemistry

Clinical biochemistry

Comparative biochemistry

Enzymology

Free radicals

Inorganic biochemistry

Lipids and lipid metabolism

Methodology techniques and instruments in biochemistry

Nucleic acids

Peptides amino acids amines amides

Physical biochemistry